2-bromo-3-(4-bromophenoxy)-1-propanol | 145733-78-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-bromo-3-(4-bromophenoxy)-1-propanol
• 英文别名: 2-Bromo-3-(4-bromophenoxy)propan-1-ol
• CAS: 145733-78-4
• 化学式: C₉H₁₀Br₂O₂
• 分子量: 309.985
• InChiKey: AJGHAKFCIKXSMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯基缩水甘油醚 在 溴 作用下， 以 乙腈 为溶剂， 以44%的产率得到2-bromo-3-(4-bromophenoxy)-1-propanol
  参考文献：
  名称：

  Conversion of epoxides into halohydrins with elemental halogen catalyzed by thiourea

  摘要：

  A highly regioselective method for the synthesis of beta-iodohydrins and beta-bromohydrins by the direct ring opening of epoxides with elemental halogen in the presence of thiourea is described. This method occurs under neutral and mild conditions with high yields in various solvents even when sensitive functional groups are present. (C) 2003 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2003.09.033

文献信息

• Halogenation reactions of epoxides
  作者：Monica I. Konaklieva、Michele L. Dahl、Edward Turos

  DOI：10.1016/s0040-4039(00)60844-4

  日期：1992.11

  The halogenation of aryl and alkyl epoxides using elemental bromine or iodine has been studied.
• US4209639A
  申请人：——

  公开号：US4209639A

  公开（公告）日：1980-06-24
• Conversion of epoxides into halohydrins with elemental halogen catalyzed by thiourea
  作者：Hashem Sharghi、Mohammad Mehdi Eskandari

  DOI：10.1016/j.tet.2003.09.033

  日期：2003.10

  A highly regioselective method for the synthesis of beta-iodohydrins and beta-bromohydrins by the direct ring opening of epoxides with elemental halogen in the presence of thiourea is described. This method occurs under neutral and mild conditions with high yields in various solvents even when sensitive functional groups are present. (C) 2003 Published by Elsevier Ltd.