bis-(2-hydroxy-ethyl)-[2-(2-hydroxy-ethylsulfanyl)-ethyl]-sulfonium ; chloride | 107327-27-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: bis-(2-hydroxy-ethyl)-[2-(2-hydroxy-ethylsulfanyl)-ethyl]-sulfonium ; chloride
• 英文别名: Bis-(2-hydroxy-aethyl)-[2-(2-hydroxy-aethylmercapto)-aethyl]-sulfonium; Chlorid；Thiobisethanol (chloroethylthio)ethyl chloride；bis(2-hydroxyethyl)-[2-(2-hydroxyethylsulfanyl)ethyl]sulfanium;chloride
• CAS: 107327-27-5
• 化学式: C₈H₁₉O₃S₂*Cl
• 分子量: 262.822
• InChiKey: WYJZJYWOILWYBQ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -3.68
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  bis (2-chloroethyl) sulphide 在 水 作用下， 生成 bis-(2-hydroxy-ethyl)-[2-(2-hydroxy-ethylsulfanyl)-ethyl]-sulfonium ; chloride
  参考文献：
  名称：

  Stein; Moore; Bergmann, Journal of Organic Chemistry, 1946, vol. 11, p. 668,672

  摘要：

  DOI：

文献信息

• Direct NMR measurements of sulfonium chlorides produced from the hydrolyses of 2-chloroethyl sulfides
  作者：Yu Chu Yang、Linda L. Szafraniec、William T. Beaudry、J. Richard Ward

  DOI：10.1021/jo00384a058

  日期：1987.4
• Locus-Specific Microemulsion Catalysts for Sulfur Mustard (HD) Chemical Warfare Agent Decontamination
  作者：Ian A. Fallis、Peter C. Griffiths、Terence Cosgrove、Cecile A. Dreiss、Norman Govan、Richard K. Heenan、Ian Holden、Robert L. Jenkins、Stephen J. Mitchell、Stuart Notman、Jamie A. Platts、James Riches、Thomas Tatchell

  DOI：10.1021/ja901872y

  日期：2009.7.22

  The rates of catalytic oxidative decontamination of the chemical warfare agent (CWA) sulfur mustard (HD, bis(2-chlororethyl) sulfide) and a range (chloroethyl) sulfide simulants of variable lipophilicity have been examined using a hydrogen peroxide-based microemulsion system. SANS (small-angle neutron scattering), SAXS (small-angle X-ray scattering), PGSE-NMR (pulsed-gradient spin-echo NMR), fluorescence quenching, and electrospray mass spectroscopy (ESI-MS) were implemented to examine the distribution of HD, its simulants, and their oxidation/hydrolysis products in a model oil-in-water microemulsion. These measurements not only present a means of interpreting decontamination rates but also a rationale for the design of oxidation catalysts for these toxic materials. Here we show that by localizing manganese-Schiff base catalysts at the oil droplet-water interface or within the droplet core, a range of (chloroethyl) sulfides, including HD, spanning some 7 orders of octanol-water partition coefficient (K-ow), may be oxidized with equal efficacy using dilute (5 wt. % of aqueous phase) hydrogen peroxide as a noncorrosive, environmentally benign oxidant (e.g., t(1/2) (HD) similar to 18 s, (2-chloroethyl phenyl sulfide, C6H5SCH2CH2Cl) similar to 15 s, (thiodiglycol, S(CH2CH2OH)(2)) similar to 19 s 20 degrees C}). Our observations demonstrate that by programming catalyst lipophilicity to colocalize catalyst and substrate, the inherent compartmentalization of the microemulsion can be exploited to achieve enhanced rates of reaction or to exert control over product selectivity. A combination of SANS, ESI-MS and fluorescence quenching measurements indicate that the enhanced catalytic activity is due to the locus of the catalyst and not a result of partial hydrolysis of the substrate.
• THE HYDROLYSIS AND OXIDATION OF β-(β'-CHLOROETHYLTHIO)-ETHYL ETHER AND RELATED COMPOUNDS¹
  作者：CHARLES C. PRICE、ALBERT POHLAND

  DOI：10.1021/jo01166a007

  日期：1947.3
• Partnerships and Participation: Synthesising Methods to Improve the Quality of Planning and Training for Primary Health Care Services at District Level in Nepal
  作者：Kate Butcher、Pitamber Dhungana、Badri Pant、Krishna Prasai

  DOI：10.1111/j.1759-5436.2000.mp31001015.x

  日期：2000.1

  Participation has been encouraged for many years in health development work, as a means to involve populations in improving the appropriateness and quality of their local health services. This article is an attempt to highlight a new approach to participation which moves away from a purely community focused activity and seeks to engage a broader partnership between health service providers, managers and users for a more accountable and sustainable end product. It takes inspiration from the Client Oriented Provider Efficient process (COPE) which has been proved an effective tool to improve the qualify of reproductive health services. Mixing some of its core components with Participatory Learning and Action (PLA) methods we have developed a new model of participatory planning and training. Preliminary results show that including all stakeholders in the process can work as long as the exercises are accessible to all. This accessibility is achieved through a range of visualisation methods. As with any tool for Human Resource Development the crucial issue continues to be the need for effective follow up which can maintain levels of enthusiasm and quality in resource-poor settings.
• Stein; Moore; Bergmann, Journal of Organic Chemistry, 1946, vol. 11, p. 668,672
  作者：Stein、Moore、Bergmann

  DOI：——

  日期：——