(2R,3R)-2,3-dihydroxy-3-methylpetanoic acid | 37504-87-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R,3R)-2,3-dihydroxy-3-methylpetanoic acid
• 英文别名: (2R,3R)-2,3-dihydroxy-3-methyl-pentanoic acid；3-methyl-D-erythro-4,5-dideoxy-pentonic acid；(2R,3R)-2,3-dihydroxy-3-methyl-valeric acid；D_r-2r_F,3c_F-Dihydroxy-3t_F-methyl-valeriansaeure；D_g-erythro-2,3-Dihydroxy-3-methyl-valeriansaeure；(2R,3R)-2,3-Dihydroxy-3-methyl-valeriansaeure；(2R,3R)-2,3-dihydroxy-3-methylpentanoic acid
• CAS: 37504-87-3
• 化学式: C₆H₁₂O₄
• 分子量: 148.159
• InChiKey: PDGXJDXVGMHUIR-UJURSFKZSA-N

物化性质

• 沸点：
  333.2±27.0 °C(Predicted)
• 密度：
  1.259±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2R,3R)-2,3-dihydroxy-3-methylpetanoic acid 生成 2-hydroxy-2-methylbutanal
  参考文献：
  名称：

  Crout; Whitehouse, Journal of the Chemical Society. Perkin transactions I, 1977, # 5, p. 544 - 549

  摘要：

  DOI：
• 作为产物：
  描述：

  3-ethyl-3-methyl-oxiranecarboxylic acid ethyl ester 在 barium dihydroxide 、 硫酸 作用下， 以 甲醇 为溶剂， 生成 (2R,3R)-2,3-dihydroxy-3-methylpetanoic acid
  参考文献：
  名称：

  Continuing Studies on the Cyanobacterium Lyngbya sp.: Isolation and Structure Determination of 15-Norlyngbyapeptin A and Lyngbyabellin D

  摘要：

  Re-collections of the cyanobacterium Lyngbya sp. have yielded two more members of the lyngbyapeptin and lyngbyabellin families. The gross structures of 15-norlyngbyapeptin A (1) and lyngbyabellin D (3) were deduced through standard 2D NMR techniques, with the absolute configuration of both elucidated through degradation and comparison with commercially available and synthetic standards. Degradation to the a-amino acid and NOE correlations determined the absolute and relative configuration of the 4-amino-3-hydroxy-5-methylhexanoic acid unit in 3. Lyngbyabellin D (3) displayed an IC50 value of 0.1 mM against the KB cell line.

  DOI：

  10.1021/np030011g

文献信息

• Absolute configuration of 2,3-dihydroxy-3-methylpentanoic acid, an intermediate in the biosynthesis of isoleucine
  作者：D. H. G. Crout、D. Whitehouse

  DOI：10.1039/c39720000398

  日期：——

  The dihydroxy-acid precursor (VII) of isoleucine (IX) is shown to have the 2R,3R-configuration.

  异亮氨酸（IX）的二羟基酸前体（VII）显示具有2 R，3 R-构型。
• NOVEL PROMOTER AND METHOD FOR PRODUCING DESIRED SUBSTANCE USING SAME
  申请人：CJ Cheiljedang Corporation

  公开号：EP4023756A1

  公开（公告）日：2022-07-06

  The present application relates to a novel promoter and a method for producing a desired substance using the same.

  本申请涉及一种新型促进剂和使用该促进剂生产所需物质的方法。
• Armstrong, Frank B.; Lipscomb, Elizabeth L.; Crout, David H. G., Journal of the Chemical Society. Perkin transactions I, 1985, p. 691 - 696
  作者：Armstrong, Frank B.、Lipscomb, Elizabeth L.、Crout, David H. G.、Morgan, Phillip J.

  DOI：——

  日期：——
• ADELBERG; BONNER; TATUM, Journal of Biological Chemistry, 1951, vol. 190, # 2, p. 837 - 841
  作者：ADELBERG、BONNER、TATUM

  DOI：——

  日期：——
• Adelberg, Journal of Bacteriology, 1951, vol. 61, p. 365,366
  作者：Adelberg

  DOI：——

  日期：——