bis(p-nitrophenyl) nonane-1,9-dioate | 49759-34-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: bis(p-nitrophenyl) nonane-1,9-dioate
• 英文别名: Azelainsaeure-bis-<4-nitro-phenylester>；Azelainsaeure-bis-(4-nitro-phenylester)；Bis(4-nitrophenyl) nonanedioate
• CAS: 49759-34-4
• 化学式: C₂₁H₂₂N₂O₈
• 分子量: 430.414
• InChiKey: WVRQLWQXFNTEJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  144
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  bis(p-nitrophenyl) nonane-1,9-dioate 在 盐酸 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 nonanedioic acid bis-({3-[4-(3-amino-propylamino)-butylamino]-propyl}-amide); compound with GENERIC INORGANIC NEUTRAL COMPONENT
  参考文献：
  名称：

  Synthesis of bis-spermine dimers that are potent polyamine transport inhibitors

  摘要：

  A series of novel spermine dimer analogues was synthesized and assessed for their ability to inhibit spermidine transport into MDA-MB-231 breast carcinoma cells, Two spermine molecules were tethered via their N-1 primary amines with naphthalenedisulfonic acid, adamantanedicarboxylic acid and a series of aliphatic dicarboxylic acids. The linked spermine analogues were potent polyamine transport inhibitors and inhibited cell growth cytostatically in combination with a polyamine synthesis inhibitor. Variation in the linker length did not alter polyamine transport inhibition. The amount of charge on the molecule may influence the molecular interaction with the transporter since the most potent spermidine transport inhibitors contained 5-6 positive charges. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00659-x
• 作为产物：
  描述：

  壬二酸 、 对硝基苯酚 生成 bis(p-nitrophenyl) nonane-1,9-dioate
  参考文献：
  名称：

  Zahn,H.; Schade,F., Chemische Berichte, 1963, vol. 96, p. 1747 - 1750

  摘要：

  DOI：

文献信息

• Okuno, Yohmei; Horita, Kiyoshi; Yonemitsu, Osamu, Journal of the Chemical Society. Perkin transactions I, 1984, # 5, p. 1115 - 1118
  作者：Okuno, Yohmei、Horita, Kiyoshi、Yonemitsu, Osamu、Shibata, Kazue、Amemiya, Toshiyuki、Holm, Richard H.

  DOI：——

  日期：——
• OKUNO, YOHMEI;HORITA, KIYOSHI;YONEMITSU, OSAMU;SHIBATA, KAZUE;AMEMIYA, TO+, J. CHEM. SOC. PERKIN TRANS., 1984, N 5, 1115-1118
  作者：OKUNO, YOHMEI、HORITA, KIYOSHI、YONEMITSU, OSAMU、SHIBATA, KAZUE、AMEMIYA, TO+

  DOI：——

  日期：——
• Zahn,H.; Schade,F., Chemische Berichte, 1963, vol. 96, p. 1747 - 1750
  作者：Zahn,H.、Schade,F.

  DOI：——

  日期：——
• Synthesis of bis-spermine dimers that are potent polyamine transport inhibitors
  作者：Gerard F. Graminski、C.Lance Carlson、Josh R. Ziemer、Feng Cai、Nicolaas M.J. Vermeulen、Scott M. Vanderwerf、Mark R. Burns

  DOI：10.1016/s0960-894x(01)00659-x

  日期：2002.1

  A series of novel spermine dimer analogues was synthesized and assessed for their ability to inhibit spermidine transport into MDA-MB-231 breast carcinoma cells, Two spermine molecules were tethered via their N-1 primary amines with naphthalenedisulfonic acid, adamantanedicarboxylic acid and a series of aliphatic dicarboxylic acids. The linked spermine analogues were potent polyamine transport inhibitors and inhibited cell growth cytostatically in combination with a polyamine synthesis inhibitor. Variation in the linker length did not alter polyamine transport inhibition. The amount of charge on the molecule may influence the molecular interaction with the transporter since the most potent spermidine transport inhibitors contained 5-6 positive charges. (C) 2001 Elsevier Science Ltd. All rights reserved.