N-<(morpholin-4-yl)methylcarbonyl>anthranilic acid ethyl ester | 101496-75-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-<(morpholin-4-yl)methylcarbonyl>anthranilic acid ethyl ester
• 英文别名: N-morpholinoacetyl-anthranilic acid ethyl ester；N-Morpholinoacetyl-anthranilsaeure-aethylester；Ethyl 2-[(2-morpholin-4-ylacetyl)amino]benzoate
• CAS: 101496-75-7
• 化学式: C₁₅H₂₀N₂O₄
• 分子量: 292.335
• InChiKey: SCYAFHBBVDJIMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-<(morpholin-4-yl)methylcarbonyl>anthranilic acid ethyl ester 在 potassium tert-butylate 作用下， 以 二甲基亚砜 为溶剂， 反应 0.75h， 以54%的产率得到4-hydroxy-3-morpholin-4-yl-2(1H)-quinolone
  参考文献：
  名称：

  3-Amino-2(1H)-quinolones by Cyclizaion of N-Acylated Anthranilic Acid Derivatives

  摘要：

  Reaction of secondary amines with the N-(iodoacetyl)anthranilic acid derivatives, 2-(iodoacetylamino)acetophenone and 2-(iodoacetylamino)benzophenone yields 3-amino-2(1H)-quinolones in two steps. Analogously heterocondensed 5-amino-6(7H)-pyrazolo[5,4-b]pyridones were prepared. Hydroxyquinolines were subjected to Cl/OH exchange to give chloroquinolines, which are convenient for consecutive reactions.

  DOI：

  10.3987/com-96-7700
• 作为产物：
  描述：

  吗啉 、 2-(2-氯-乙酰氨基)-苯甲酸乙酯 生成 N-<(morpholin-4-yl)methylcarbonyl>anthranilic acid ethyl ester
  参考文献：
  名称：

  Alkyl and Diethylaminoethyl Esters of N-Substituted Aminoacylaminobenzoic Acids

  摘要：

  DOI：

  10.1021/ja01578a061

文献信息

• Alkyl and Diethylaminoethyl Esters of N-Substituted Aminoacylaminobenzoic Acids
  作者：Elias Epstein、Daniel Kaminsky

  DOI：10.1021/ja01578a061

  日期：1957.11
• 3-Amino-2(1H)-quinolones by Cyclizaion of N-Acylated Anthranilic Acid Derivatives
  作者：Matthias Rehwald、Karl Gewald、Hans-Joachim Lankau、Klaus Unverferth

  DOI：10.3987/com-96-7700

  日期：——

  Reaction of secondary amines with the N-(iodoacetyl)anthranilic acid derivatives, 2-(iodoacetylamino)acetophenone and 2-(iodoacetylamino)benzophenone yields 3-amino-2(1H)-quinolones in two steps. Analogously heterocondensed 5-amino-6(7H)-pyrazolo[5,4-b]pyridones were prepared. Hydroxyquinolines were subjected to Cl/OH exchange to give chloroquinolines, which are convenient for consecutive reactions.