2-amino-5-methoxybenzenephosphonic acid | 1426155-88-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-amino-5-methoxybenzenephosphonic acid
• 英文别名: (2-Amino-5-methoxyphenyl)phosphonic acid
• CAS: 1426155-88-5
• 化学式: C₇H₁₀NO₄P
• 分子量: 203.134
• InChiKey: CBNZJFVDURGQGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  92.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-chloro-5-methoxybenzenephosphonic acid 在 copper(I) oxide 、 氨 作用下， 以 水 为溶剂， 反应 21.0h， 生成 2-amino-5-methoxybenzenephosphonic acid
  参考文献：
  名称：

  Importance of ortho Proton Donors in Catalysis of Hydrazone Formation

  摘要：

  Anthranilic acids were recently reported as superior catalysts for hydrazone and oxime formation compared to aniline, the classic catalyst for these reactions. Here, alternative proton donors were examined with varied pK(a) in an effort to enhance activity at biological pH. The experiments show that 2-aminobenzenephosphonic acids are superior to anthranilic acids in catalyzing hydrazone formation with common aldehyde substrates.

  DOI：

  10.1021/ol400427x

文献信息

• US4642240A
  申请人：——

  公开号：US4642240A

  公开（公告）日：1987-02-10
• Importance of <i>ortho</i> Proton Donors in Catalysis of Hydrazone Formation
  作者：Pete Crisalli、Eric T. Kool

  DOI：10.1021/ol400427x

  日期：2013.4.5

  Anthranilic acids were recently reported as superior catalysts for hydrazone and oxime formation compared to aniline, the classic catalyst for these reactions. Here, alternative proton donors were examined with varied pK(a) in an effort to enhance activity at biological pH. The experiments show that 2-aminobenzenephosphonic acids are superior to anthranilic acids in catalyzing hydrazone formation with common aldehyde substrates.