2-hydroxymethyl-5,7-dimethyl-3-(2-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-6-carboxylic acid ethyl ester | 75913-83-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-hydroxymethyl-5,7-dimethyl-3-(2-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-6-carboxylic acid ethyl ester
• 英文别名: 3-(2-chlorophenyl)-6-ethoxycarbonyl-2-hydroxymethyl-5,7-dimethyl-4(3H)-quinazolinone；Ethyl 3-(2-chlorophenyl)-2-(hydroxymethyl)-5,7-dimethyl-4-oxoquinazoline-6-carboxylate
• CAS: 75913-83-6
• 化学式: C₂₀H₁₉ClN₂O₄
• 分子量: 386.835
• InChiKey: PYFWCAXBEATYFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  79.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-hydroxymethyl-5,7-dimethyl-3-(2-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-6-carboxylic acid ethyl ester 、 异氰酸甲酯 以 吡啶 为溶剂， 以85%的产率得到3,4-二氢-3-(2-氯苯基)-5,7-二甲基-2-((((甲基氨基)羰基)氧基)甲基)-4-氧代-6-喹唑啉羧酸乙酯
  参考文献：
  名称：

  新的降压药。

  摘要：

  N-烷基衍生物（1a-c），即2-氨基甲酰氧甲基-3-（2-氯苯基）-6-乙氧羰基-5,7-二甲基-4（3H）-喹唑啉酮，在麻醉兔和自发性高血压大鼠（SHR）中显示出强大的降压活性。这些化合物的降压活性归因于钙拮抗作用、抑制去甲肾上腺素释放、增强腺苷反应、中枢神经系统作用、烟碱阻断作用以及功能性的β阻断作用。其降压效果并非通过刺激肾上腺素β受体或毒蕈碱受体介导。

  DOI：

  10.1248/cpb.30.744
• 作为产物：
  描述：

  2-amino-5-ethoxycarbonyl-4,6-dimethylbenzoic acid 在 溴 、 sodium ethanolate 、 三氯化磷 作用下， 以 乙醇 、 溶剂黄146 、 N,N-二甲基甲酰胺 、 xylene 为溶剂， 反应 4.0h， 生成 2-hydroxymethyl-5,7-dimethyl-3-(2-chlorophenyl)-4-oxo-3,4-dihydroquinazoline-6-carboxylic acid ethyl ester
  参考文献：
  名称：

  新的降压药。

  摘要：

  N-烷基衍生物（1a-c），即2-氨基甲酰氧甲基-3-（2-氯苯基）-6-乙氧羰基-5,7-二甲基-4（3H）-喹唑啉酮，在麻醉兔和自发性高血压大鼠（SHR）中显示出强大的降压活性。这些化合物的降压活性归因于钙拮抗作用、抑制去甲肾上腺素释放、增强腺苷反应、中枢神经系统作用、烟碱阻断作用以及功能性的β阻断作用。其降压效果并非通过刺激肾上腺素β受体或毒蕈碱受体介导。

  DOI：

  10.1248/cpb.30.744

文献信息

• 4(3H)-Quinazolinone derivatives, process for production thereof, and
  申请人：Ishikawa; Masayuki

  公开号：US04451467A1

  公开（公告）日：1984-05-29

  The 4(3H)-quinazolinone compounds of the formula (I) ##STR1## wherein R.sub.1 and R.sub.3, independently from each other, represent a lower alkyl group; R.sub.2 represents a lower alkoxycarbonyl group; Q represents a phenyl group or a substituted phenyl group substituted by at least one member selected from the group consisting of halogen atoms, lower alkyl groups, lower alkoxy groups, di(lower)-alkylamino groups, a methylenedioxy group, a trifluoromethyl group, a hydroxyl group, and a nitro group; R.sub.4 represents a hydrogen atom or a lower alkyl group; R.sub.5 represents a member selected from the group consisting of a hydrogen atom, lower alkyl groups, lower halogenoalkyl groups, lower alkenyl groups, (lower)alkoxy(lower)alkyl groups, hydroxy(lower)alkyl groups, (lower)alkylthio(lower)alkyl groups, (lower)alkylsulfinyl(lower)alkyl groups, (lower)alkylsulfonyl(lower)alkyl groups, di(lower)alkylamino(lower)alkyl groups, a benzyl group, a phenethyl group, pyridyl(lower)alkyl groups, furfuryl groups, a phenyl group, and substituted phenyl groups substituted by a member selected from the group consisting of halogen atoms, lower alkyl groups, and lower alkoxy groups; and Z.sub.1 and Z.sub.2, independently from each other, represent an oxygen or sulfur atom; and an acid addition salt thereof; and a process for producing the same.

  化合物的中文翻译如下： 式(I)的4(3H)-喹唑啉酮化合物 其中R.sub.1和R.sub.3分别独立地代表低碳基团；R.sub.2代表低碳氧羰基团；Q代表苯基或被卤素原子、低碳基团、低碳氧基团、二(低碳基)氨基团、亚甲二氧基基团、三氟甲基基团、羟基和硝基等至少一种成员取代的取代苯基；R.sub.4代表氢原子或低碳基团；R.sub.5代表从氢原子、低碳基团、低卤代低碳基团、低烯基基团、(低碳基)氧基(低碳基)基团、羟基(低碳基)基团、(低碳基)硫基(低碳基)基团、(低碳基)亚砜基(低碳基)基团、二(低碳基)氨基(低碳基)基团、苄基、苯乙基、吡啶(低碳基)基团、呋喃基团、苯基和被卤素原子、低碳基团和低碳氧基团中的一种成员取代的取代苯基中选择的成员中的一种；Z.sub.1和Z.sub.2分别独立地代表氧或硫原子；以及其酸加盐；以及其生产方法。
• 4(3H)-quinazolinone derivatives, process for production thereof and pharmaceutical compositions comprising said compounds
  申请人：Ishikawa, Masayuki

  公开号：EP0056637A1

  公开（公告）日：1982-07-28

  4(3H)-quinazolinones of formula wherein R1 and R3, independently from each other, represent a lower alkyl group; R2 represents a lower alkoxycarbonyl group; Q represents a phenyl group or a substituted phenyl group R4 represents a hydrogen atom or a lower alkyl group; R5 represents a member selected from the group consisting of a hydrogen atom, lower alkyl groups, lower halogenoalkyl groups, lower alkenyl groups, (lower)alkoxy-(lower)alkyl groups, hydroxy(lower)alkyl groups, (lower) alkylthio(lower)alkyl groups, (lower)alkylsulfinyl(lower) alkyl groups, (lower)alkylsulfonyl(lower)alkyl groups, di(lower)-alkylamino(lower)alkyl groups, a benzyl group, a phenethyl group, pyridyl(lower)alkyl groups, furfuryl groups, a phenyl group, and substituted phenyl groups. Z, and Z2, independently from each other, represent an oxygen or sulfur atom; and an acid addition salts thereof, are useful as hypotensive agents. There is also disclosed a process for the production of these derivatives and pharmaceutical compositions comprising said compounds.

  式中的 4(3H)-喹唑啉酮 式中 R1 和 R3 各自代表一个低级烷基 R2 代表低级烷氧基羰基 Q 代表苯基或取代苯基 R4 代表氢原子或低级烷基 R5 代表选自由氢原子、低级烷基、低级卤代烷基、低级烯基、(低级)烷氧基-(低级)烷基、羟基(低级)烷基、(低级)烷硫基(低级)烷基组成的组、(低级)烷基亚磺酰(低级)烷基、(低级)烷基磺酰基、二(低级)烷基氨基(低级)烷基、苄基、苯乙基、吡啶基(低级)烷基、糠基、苯基和取代苯基。 Z和Z2相互独立地代表氧原子或硫原子；其酸加成盐可用作降血压剂。还公开了一种生产这些衍生物和包含上述化合物的药物组合物的工艺。
• A Facile Synthesis of <i>C</i>₂,<i>N</i>₃-Disubstituted-4-quinazolone
  作者：Song Xue、Joseph McKenna、Wen-Chung Shieh、Oljan Repič

  DOI：10.1021/jo049118e

  日期：2004.9.1

  A simple and efficient methodology for the synthesis Of C-2,N-3-disubstituted-4 quinazolones from anilines and N-acylanthranilic acids was developed. The new cyclization conditions are much milder than any other reported protocols and resulted in excellent yields (87-98%) without chromatography.
• ISHIKAWA, MASAYUKI;EGUCHI, JUKUO;MORIGUCHI, SOYAO;EBISAWA, HISASHI
  作者：ISHIKAWA, MASAYUKI、EGUCHI, JUKUO、MORIGUCHI, SOYAO、EBISAWA, HISASHI

  DOI：——

  日期：——
• US4276295A
  申请人：——

  公开号：US4276295A

  公开（公告）日：1981-06-30