2-(2-hydroxyethylamino)-1,4,5,6-tetrahydropyrimidine | 98278-62-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(2-hydroxyethylamino)-1,4,5,6-tetrahydropyrimidine
• 英文别名: 2-(1,4,5,6-tetrahydro-pyrimidin-2-ylamino)-ethanol；2-(1,4,5,6-Tetrahydro-pyrimidin-2-ylamino)-aethanol；2-(1,4,5,6-Tetrahydropyrimidin-2-ylamino)ethanol
• CAS: 98278-62-7
• 化学式: C₆H₁₃N₃O
• mdl: MFCD00154771
• 分子量: 143.189
• InChiKey: HWSAQMXBJNZVMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  56.6
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(甲基硫代)-1,4,5,6-四氢嘧啶氢碘酸 、 C.I.酸性橙108 生成 2-(2-hydroxyethylamino)-1,4,5,6-tetrahydropyrimidine
  参考文献：
  名称：

  PREPARATION AND CHEMISTRY OF Δ⁸-HEXAHYDRO-1,4,8-PYRIMIDAZOLE, Δ⁹-1,5,9-TRIAZABICYCLO(4.4.0)DECENE, AND Δ⁹-1,4,9-TRIAZABICYGLO(5.3.0)DECENE

  摘要：

  Δ⁸-六氢-1,4,8-嘧啶，Δ⁹-1,5,9-三氮杂双环(4.4.0)癸烯和Δ⁹-1,4,9-三氮杂双环(5.3.0)癸烯的制备方法从相应的2-(ω-羟基烷基氨基)-Δ²-1,3-二氮杂环烯经氯化和脱卤反应得到。这些双环化合物的硝基衍生物在回流乙醇中比1-硝基-2,3,5,6-四氢-1-咪唑(1,2-a)咪唑稳定。

  DOI：

  10.1139/v57-190

文献信息

• Synthesis of five- and six-membered cyclic guanidines by guanylation with isothiouronium iodides and amines under mild conditions
  作者：Naoto Aoyagi、Takeshi Endo

  DOI：10.1080/00397911.2016.1269927

  日期：2017.3.4

  ABSTRACT Cyclic guanidine hydroiodides were obtained in one step by the reactions of isothiouronium iodides with an equimolar amount of various amines in tetrahydrofuran. The obtained hydroiodides were neutralized with sodium hydroxide or anionic exchange resin to afford the corresponding substituted cyclic guanidines in quantitative yields. GRAPHICAL ABSTRACT

  摘要 通过异硫脲碘化物与等摩尔量的各种胺在四氢呋喃中反应，一步得到环状氢碘化胍。所得氢碘化物用氢氧化钠或阴离子交换树脂中和，以定量产率提供相应的取代环胍。图形概要
• PREPARATION AND CHEMISTRY OF Δ⁸-HEXAHYDRO-1,4,8-PYRIMIDAZOLE, Δ⁹-1,5,9-TRIAZABICYCLO(4.4.0)DECENE, AND Δ⁹-1,4,9-TRIAZABICYGLO(5.3.0)DECENE
  作者：A. F. Mckay、M.-E. Kreling

  DOI：10.1139/v57-190

  日期：1957.12.1

  The preparations of Δ⁸-hexahydro-1,4,8-pyrimidazole, Δ⁹-1,5,9-triazabicyclo(4.4.0)decene, and Δ⁹-1,4,9-triazabicyclo(5.3.0)decene from the corresponding 2-(ω-hydroxyalkylamino)-Δ²-1,3-diazacycloalkenes by chlorination and dehydrohalogenation are described. The nitro derivatives of these bicyclic compounds are more stable towards refluxing ethanol than 1-nitro-2,3,5,6-tetrahydro-1-imidaz(1,2-a)imidazole.

  Δ⁸-六氢-1,4,8-嘧啶，Δ⁹-1,5,9-三氮杂双环(4.4.0)癸烯和Δ⁹-1,4,9-三氮杂双环(5.3.0)癸烯的制备方法从相应的2-(ω-羟基烷基氨基)-Δ²-1,3-二氮杂环烯经氯化和脱卤反应得到。这些双环化合物的硝基衍生物在回流乙醇中比1-硝基-2,3,5,6-四氢-1-咪唑(1,2-a)咪唑稳定。