2-(1-Amino-cyclopropyl)-ethanol hydrochloride | 753023-56-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(1-Amino-cyclopropyl)-ethanol hydrochloride
• 英文别名: 2-(1-Aminocyclopropyl)ethan-1-ol hydrochloride；2-(1-aminocyclopropyl)ethanol;hydrochloride
• CAS: 753023-56-2
• 化学式: C₅H₁₁NO*ClH
• mdl: MFCD22741236
• 分子量: 137.609
• InChiKey: ZDXCGSRAZSWQJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.87
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(1-Amino-cyclopropyl)-ethanol hydrochloride 在 titanium(IV) tetraethanolate 、 sodium cyanoborohydride 、 碳酸氢钠 、 戴斯-马丁氧化剂 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 tert-butyl ((S)-(7-((R)-cyclopropyl((2-(1-(1,3-dioxoisoindolin-2-yl)cyclopropyl)ethyl)amino)methyl)imidazo[1,2-b]pyridazin-2-yl)(4,4-difluorocyclohexyl)methyl)carbamate
  参考文献：
  名称：

  [EN] IMIDAZOPYRIDAZINE IL-17 INHIBITOR COMPOUNDS
  [FR] COMPOSÉS INHIBITEURS DE L'IL-17 TELS QUE L'IMIDAZOPYRIDAZINE

  摘要：

  The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

  公开号：

  WO2023049887A1
• 作为产物：
  描述：

  1-(2-(benzyloxy)ethyl)cyclopropanamine 在 palladium 10% on activated carbon 盐酸 、 氢气 作用下， 以 异丙醇 为溶剂， 40.0 ℃ 、405.33 kPa 条件下， 生成 2-(1-Amino-cyclopropyl)-ethanol hydrochloride
  参考文献：
  名称：

  EP1454909

  摘要：

  公开号：

文献信息

• [EN] COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE<br/>[FR] COMPOSÉ POUR LE TRAITEMENT ET LA PROPHYLAXIE DE LA MALADIE DU VIRUS RESPIRATOIRE SYNCYTIAL
  申请人：HOFFMANN LA ROCHE

  公开号：WO2013020993A1

  公开（公告）日：2013-02-14

  A compound of formula (I), as well as pharmaceutically acceptable salt thereof, wherein R1 to R10, A, Q, X and Y are as defined in description and in claims, can be used as a medicament for the treatment of respiratory syncytial virus.

  式（I）的化合物，以及其药学上可接受的盐，其中R1至R10，A，Q，X和Y如描述和索赔中定义的，可用作治疗呼吸道合胞病毒的药物。
• Substituted 8'-pyridinyl-dihydrospiro-[cycloalkyl]-pyrimido[1,2-a]pyrimidin-6-one and 8'-pyrimidinyl-dihydrospiro-[cycloalkyl]-pyrimido[1,2-a]pyrimidin-6-one derivatives
  申请人：George Pascal

  公开号：US20060025431A1

  公开（公告）日：2006-02-02

  The invention relates to a dihydrospiro-[cycloalkyl]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, m, n, p and q are as described herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β, such as Alzheimer disease.

  该发明涉及一种由式（I）表示的二氢螺-[环烷基]-嘧啶酮衍生物或其盐：其中X、Y、R1、R2、R3、m、n、p和q如本文所述。该发明还涉及一种药物，包括所述衍生物或其盐作为活性成分，用于预防和/或治疗由GSK3β异常活性引起的神经退行性疾病，例如阿尔茨海默病。
• SUBSTITUTED 8'-PYRIDINYL-DIHYDROSPIRO-[CYCLOALKYL]-PYRIMIDO[1,2-a] PYRIMIDIN-6-ONE AND 8'-PYRIMIDINYL-DIHYDROSPIRO-[CYCLOALKYL]-PYRIMIDO[1,2-a] PYRIMIDIN-6-ONE DERIVATIVES
  申请人：GEORGE Pascal

  公开号：US20080081819A1

  公开（公告）日：2008-04-03

  The invention relates to therapeutic uses of a dihydrospiro-[cycloalkyl]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, m, n, p and q are as described herein. Specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β, such as Alzheimer disease.

  本发明涉及一种二氢螺[环烷基]嘧啶酮衍生物或其盐的治疗用途，其化学式如下：其中X、Y、R1、R2、R3、m、n、p和q如本文所述。具体而言，本发明涉及一种药物，包括上述衍生物或其盐作为活性成分，用于预防和/或治疗由GSK3β异常活性引起的神经退行性疾病，如阿尔茨海默病。
• Substituted 8′-pyridinyl-dihydrospiro-[cycloalkyl]-pyrimido[1,2-a] pyrimidin-6-one and 8′-pyrimidinyl-dihydrospiro-[cycloalkyl]-pyrimido[1,2-a] pyrimidin-6-one derivatives
  申请人：Sanofi-Aventis

  公开号：US07507743B2

  公开（公告）日：2009-03-24

  The invention relates to therapeutic uses of a dihydrospiro-[cycloalkyl]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein X, Y, R1, R2, R3, m, n, p and q are as described herein. Specifically, the invention relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β, such as Alzheimer disease.

  本发明涉及一种二氢螺-[环烷基]-嘧啶酮衍生物或其盐的治疗用途，其化学式表示为(I)，其中X、Y、R1、R2、R3、m、n、p和q如本文所述。具体而言，本发明涉及一种药物，其包括所述衍生物或其盐作为活性成分，用于预防和/或治疗由GSK3β异常活性引起的神经退行性疾病，例如阿尔茨海默病。
• Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
  申请人：Chen Li

  公开号：US08871756B2

  公开（公告）日：2014-10-28

  A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R10, A, Q, X and Y are as defined in the specification and claims, and their use as a pharmaceutical for the treatment or prophylaxis of respiratory syncytial virus disease.

  化合物式（I）及其药学上可接受的盐，其中R1至R10，A，Q，X和Y如规范和要求中所定义，并且它们用于治疗或预防呼吸道合胞病毒疾病的药物。