3-[N-(2-cyanoethyl)-N-ethylamino]propionitrile | 1555-57-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-[N-(2-cyanoethyl)-N-ethylamino]propionitrile
• 英文别名: Ethyl-bis-<2-cyan-ethyl>-amin；Ethyl-bis-<2-cyano-ethyl>-amin；Ethyl-di(2-cyanoethyl)-ammonium；Bis-(2-cyanoethyl)-ethylamin；Bis-(β-cyanoethyl)-ethylamin；N-Ethyl-N,N-di-(2-cyanaethyl)-amin；3,3'-Aethylimino-di-propionitril；3,3'-ethylimino-di-propionitrile；Aethyl-bis-(2-cyan-aethyl)-amin；N-(2-cyanoethyl)-N-ethyl-3-aminopropiononitrile；N,N-bis(2-cyanoethyl)-ethylamine；3-[N-(2-Cyano-ethyl)-N-ethyl-amino]-propionitrile；3-[2-cyanoethyl(ethyl)amino]propanenitrile
• CAS: 1555-57-3
• 化学式: C₈H₁₃N₃
• mdl: MFCD16041187
• 分子量: 151.211
• InChiKey: AQAGWSWODZXNOM-UHFFFAOYSA-N

物化性质

• 熔点：
  49-50 °C
• 沸点：
  177-178 °C(Press: 10 Torr)
• 密度：
  0.9730 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  50.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-[N-(2-cyanoethyl)-N-ethylamino]propionitrile 在 potassium tert-butylate 、 sodium ethanolate 作用下， 以 乙醇 、 叔丁醇 为溶剂， 反应 2.0h， 生成 ethyl N-(5-cyano-1-ethyl-3,6-dihydro-2H-pyridin-4-yl)carbamate
  参考文献：
  名称：

  Anxiolytic properties of certain annelated [1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-ones

  摘要：

  Modification of the benzodiazepine (BZ) receptor binding template 2-aryl[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one by replacement of the annelated benzene ring with various alicyclic and heterocyclic moieties led to novel structures with potent BZ receptor binding affinity. High affinity was found in some cycloalkyl-annelated [1,2,4]triazolo-[1,5-c]pyrimidin-5(6H)-ones and in some 7,8,9,10-tetrahydropyrido[3,4-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-ones, in which the degree of activity was strongly dependent on the N-substituent in the 9-position. Nine compounds with BZ receptor IC50 binding affinity values equal or superior to diazepam were evaluated in secondary screening. One of these, 9-benzyl-2-phenyl-7,8,9,10-tetrahydropyrido[3,4-e]?? [1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one, showed good activity in rats as a potential anxiolytic agent without sedative liability. However, it increased the rotorod deficit produced by ethanol at anxiolytic doses, an indication of alcohol interaction. Thus, none of the compounds showed an advantage over CGS 9896 (Yokoyama et al. J. Med. Chem. 1982, 25, 337-339), which is free of sedative and alcohol interaction potential as measured by the test procedures described.

  DOI：

  10.1021/jm00113a032
• 作为产物：
  描述：

  双(2-氰基乙基)胺 在 sodium cyanoborohydride 作用下， 以 甲醇 、 乙腈 为溶剂， 以52%的产率得到3-[N-(2-cyanoethyl)-N-ethylamino]propionitrile
  参考文献：
  名称：

  Polyamine-linked acridine dimers

  摘要：

  一系列新型的聚胺连接的吖啶二聚物及其衍生物被描述。这些聚胺连接的吖啶二聚物及其衍生物是潜在的抗癌剂。

  公开号：

  US05886185A1

文献信息

• Novel sulfonyldiazomethanes, photoacid generators, resist compositions, and patterning process
  申请人：——

  公开号：US20040167322A1

  公开（公告）日：2004-08-26

  A chemical amplification type resist composition comprising a specific benzenesulfonyldiazomethane containing a long-chain alkoxyl group at the 2-position on benzene ring has many advantages including improved resolution, improved focus latitude, minimized line width variation or shape degradation even on long-term PED, minimized debris left after coating, development and peeling, and improved pattern profile after development and is thus suited for microfabrication.

  一种化学放大型抗蚀组合物，包括在苯环上的2-位含有长链烷氧基基团的特定苯磺酰二氮甲烷，具有许多优点，包括提高分辨率，改善焦点宽度，即使在长期PED上也减少线宽变化或形状退化，涂层、显影和剥离后减少残留物，并在显影后改善图案轮廓，因此适用于微加工。
• Linker-modified triamine-linked acridine dimers: Synthesis and cytotoxicity properties in vitro and in vivo
  作者：Shan-Shue Wang、Yi-Jen Lee、Shih-Chung Hsu、Hsueh-O Chang、Wei-Kung Yin、Lien-Shange Chang、Shan-Yen Chou

  DOI：10.1016/j.bmc.2006.10.054

  日期：2007.1

  preparation and cytotoxicity properties of a series of N(epsilon)-substituted triamine-linked acridine dimers are described. Most acridine dimer derivatives reveal highly potent in vitro cytotoxicity properties and DNA binding activity. Several acridine dimers were selected to study their action in vivo. These acridine dimers have demonstrated a narrow safe margin, as has adriamycin, but higher maximum

  描述了一系列N（ε）取代的三胺连接的a啶二聚体的制备和细胞毒性。大多数a啶二聚体衍生物具有很强的体外细胞毒性和DNA结合活性。选择了几种a啶二聚体以研究其在体内的作用。与阿霉素相比，这些demonstrated啶二聚体已显示出狭窄的安全范围，但与ICR小鼠中的阿霉素相比，其最大耐受剂量（MTD）更高。cr啶二聚体在体内还表现出各种抗anol-COLO 205实体肿瘤活性。化合物1显示出最有效的实体瘤抑制作用。
• Photoacid generators, chemically amplified resist compositions, and patterning process
  申请人：Ohsawa Youichi

  公开号：US20070292768A1

  公开（公告）日：2007-12-20

  A photoacid generator has formula (1). A chemically amplified resist composition comprising the photoacid generator has advantages including a high resolution, focus latitude, long-term PED dimensional stability, and a satisfactory pattern profile shape. When the photoacid generator is combined with a resin having acid labile groups other than those of the acetal type, resolution and top loss are improved. The composition is suited for deep UV lithography.

  一种光酸发生剂的化学式为（1）。包括该光酸发生剂的化学增感抗蚀组合物具有诸如高分辨率、焦点宽度、长期PED尺寸稳定性和令人满意的图案轮廓形状等优点。当该光酸发生剂与具有除了缩醛类型以外的酸敏感基团的树脂结合时，可以改善分辨率和顶部损失。该组合物适用于深紫外光刻。
• Resist composition and patterning process
  申请人：Watanabe Satoshi

  公开号：US20100009299A1

  公开（公告）日：2010-01-14

  The present invention relates to: a resist composition such as a chemically amplified resist composition for providing an excellent pattern profile even at a substrate-side boundary face of resist, in addition to a higher resolution in photolithography for micro-fabrication, and particularly in photolithography adopting, as an exposure source, KrF laser, ArF laser, F 2 laser, ultra-short ultraviolet light, electron beam, X-rays, or the like; and a patterning process utilizing the resist composition. The present invention provides a chemically amplified resist composition comprising one or more kinds of amine compounds or amine oxide compounds (except for those having a nitrogen atom of amine or amine oxide included in a ring structure of an aromatic ring) at least having a carboxyl group and having no hydrogen atoms covalently bonded to a nitrogen atom as a basic center.

  本发明涉及一种抗蚀组合物，例如用于在抗蚀物的基板侧边界面上提供优异图案轮廓的化学增感抗蚀组合物，除了在微细加工的光刻工艺中具有更高的分辨率外，特别是在采用KrF激光、ArF激光、F2激光、超短紫外光、电子束、X射线等作为曝光光源的光刻工艺中；以及利用该抗蚀组合物的图案化工艺。本发明提供一种化学增感抗蚀组合物，其包括一种或多种胺化合物或胺氧化合物（除了那些在芳香环的环结构中不含有胺或胺氧原子的氮原子的化合物），至少具有一个羧基，并且没有氢原子共价键结合到氮原子作为碱性中心。
• POSITIVE RESIST COMPOSITION AND PATTERNING PROCESS
  申请人：NISHI Tsunehiro

  公开号：US20100062374A1

  公开（公告）日：2010-03-11

  A positive resist composition comprises (A) a resin component which becomes soluble in an alkaline developer under the action of an acid and (B) an acid generator. The resin (A) is a polymer comprising recurring units containing a non-leaving hydroxyl group represented by formula (1) wherein R 1 is H, methyl or trifluoromethyl, X is a single bond or methylene, m is 1 or 2, and the hydroxyl group attaches to a secondary carbon atom. The composition is improved in resolution when processed by lithography.

  一种正性光刻胶组合物包括（A）在酸的作用下在碱性显影剂中变得可溶的树脂组分和（B）酸发生剂。树脂（A）是一种聚合物，包含由式（1）表示的非离去羟基的重复单元，其中R1为H、甲基或三氟甲基，X为单键或亚甲基，m为1或2，并且羟基连接到次级碳原子。当通过光刻工艺处理时，该组合物在分辨率方面得到改善。