Benzoic acid, 4-((((((2,3-dihydro-2,2-dimethyl-7-benzofuranyl)oxy)carbonyl)methylamino)oxoacetyl)oxy)- | 105315-55-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: Benzoic acid, 4-((((((2,3-dihydro-2,2-dimethyl-7-benzofuranyl)oxy)carbonyl)methylamino)oxoacetyl)oxy)-
• 英文别名: 4-[2-[(2,2-dimethyl-3H-1-benzofuran-7-yl)oxycarbonyl-methylamino]-2-oxoacetyl]oxybenzoic acid
• CAS: 105315-55-7
• 化学式: C₂₁H₁₉NO₈
• 分子量: 413.384
• InChiKey: VGFJUNDGAXYGNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  119
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  克百威 在 三乙胺 作用下， 以 乙醚 、 1,2-二氯乙烷 为溶剂， 生成 Benzoic acid, 4-((((((2,3-dihydro-2,2-dimethyl-7-benzofuranyl)oxy)carbonyl)methylamino)oxoacetyl)oxy)-
  参考文献：
  名称：

  Synthesis and Insecticidal Activity of Novel N-Oxalyl-N-methylcarbamates

  摘要：

  A series of novel 2,3-dihydro-2,2-dimethyl-7-benzofuranyl N-oxalyl-N-methylcarbamate insecticides (N-oxalyl derivatives of carbofuran) containing carboxylic acid or carboxylate substituent were prepared. N-Oxalyl derivatives of carbofuran were examined for toxicity to white mice and a wide variety of economically important pests and for systemic activity in plants. Compared to the parent insecticide, carbofuran, the derivatives displayed significantly reduced toxicity to the white mouse. Two of the derivatives [oxamic acid, carboxymethyl-, (2,3-dihydro-2,2-dimethyl-7-benzofuranyl) ester, ester with methyl salicylate, compound 1; and oxamic acid, carboxymethyl-, (2,3-dihydro-2,2-dimethyl-7-benzofuranyl) ester, ester with methyl p-hydroxybenzoate, compound 8] showed 700-1000 times less toxicity to the mouse than the nonderivatized carbofuran on a weight basis. All of the derivatives were highly effective insecticides against a wide variety of insects. The derivatives also displayed a wide spectrum of systemic pesticide activity comparable or superior to carbofuran in the cut stem, soil, and foliar applications.

  DOI：

  10.1021/jf00040a035

文献信息

• ——
  作者：MALLIPUDI NARAYANA M.、 HOLLINGSHAUS JOHN G.

  DOI：——

  日期：——
• Synthesis and Insecticidal Activity of Novel N-Oxalyl-N-methylcarbamates
  作者：N. Moorthy Mallipudi、Anhorng Lee、Inder P. Kapoor、Gary J. Hollingshaus

  DOI：10.1021/jf00040a035

  日期：1994.4

  A series of novel 2,3-dihydro-2,2-dimethyl-7-benzofuranyl N-oxalyl-N-methylcarbamate insecticides (N-oxalyl derivatives of carbofuran) containing carboxylic acid or carboxylate substituent were prepared. N-Oxalyl derivatives of carbofuran were examined for toxicity to white mice and a wide variety of economically important pests and for systemic activity in plants. Compared to the parent insecticide, carbofuran, the derivatives displayed significantly reduced toxicity to the white mouse. Two of the derivatives [oxamic acid, carboxymethyl-, (2,3-dihydro-2,2-dimethyl-7-benzofuranyl) ester, ester with methyl salicylate, compound 1; and oxamic acid, carboxymethyl-, (2,3-dihydro-2,2-dimethyl-7-benzofuranyl) ester, ester with methyl p-hydroxybenzoate, compound 8] showed 700-1000 times less toxicity to the mouse than the nonderivatized carbofuran on a weight basis. All of the derivatives were highly effective insecticides against a wide variety of insects. The derivatives also displayed a wide spectrum of systemic pesticide activity comparable or superior to carbofuran in the cut stem, soil, and foliar applications.