2-ethylnonanoyl chloride | 88663-38-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: 2-ethylnonanoyl chloride
• CAS: 88663-38-1
• 化学式: C₁₁H₂₁ClO
• 分子量: 204.74
• InChiKey: TYODXJZPZUTDPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  炔诺酮 、 2-ethylnonanoyl chloride 以 吡啶 为溶剂， 反应 50.0h， 以2.1 g的产率得到norethisterone 2-ethylnonanoate
  参考文献：
  名称：

  Long-acting contraceptive agents: Esters of norethisterone with α- and/or β-chain branching

  摘要：

  The synthesis of eighteen esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) is described. These all possess some form of alpha- and/or beta-substitution in the ester side-chain. The work was undertaken in order to evaluate any long-acting fertility control effect intrinsic in such compounds. A pentamethyl disiloxy ether was also included in the group of substances prepared for testing because of its similar substitution pattern.

  DOI：

  10.1016/0039-128x(83)90096-x
• 作为产物：
  描述：

  2-乙基壬酸 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 苯 为溶剂， 生成 2-ethylnonanoyl chloride
  参考文献：
  名称：

  [EN] IONIZABLE CATIONIC LIPIDS AND LIPID NANOPARTICLES, AND METHODS OF SYNTHESIS AND USE THEREOF
  [FR] NANOPARTICULES LIPIDIQUES ET LIPIDES CATIONIQUES IONISABLES, ET LEURS PROCÉDÉS DE SYNTHÈSE ET D'UTILISATION

  摘要：

  Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.

  公开号：

  WO2023240156A1

文献信息

• [EN] DUAL MAGL AND FAAH INHIBITORS<br/>[FR] INHIBITEURS DOUBLES DE MAGL ET DE FAAH
  申请人：ABIDE THERAPEUTICS INC

  公开号：WO2018169880A1

  公开（公告）日：2018-09-20

  Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
• Long-acting contraceptive agents: Esters of norethisterone with α- and/or β-chain branching
  作者：T.G. Watson、M. Hosking、J.E. Herz、J.V. Torres、J. Muller、A. Murillo、S. Cruz、A. Shafiee、M. Vossoghi、F. Savabi、S. Sotheeswaran、V. Puvanesarajah

  DOI：10.1016/0039-128x(83)90096-x

  日期：1983.3

  The synthesis of eighteen esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) is described. These all possess some form of alpha- and/or beta-substitution in the ester side-chain. The work was undertaken in order to evaluate any long-acting fertility control effect intrinsic in such compounds. A pentamethyl disiloxy ether was also included in the group of substances prepared for testing because of its similar substitution pattern.
• [EN] IONIZABLE CATIONIC LIPIDS AND LIPID NANOPARTICLES, AND METHODS OF SYNTHESIS AND USE THEREOF<br/>[FR] NANOPARTICULES LIPIDIQUES ET LIPIDES CATIONIQUES IONISABLES, ET LEURS PROCÉDÉS DE SYNTHÈSE ET D'UTILISATION
  申请人：[en]TIDAL THERAPEUTICS, INC.

  公开号：WO2023240156A1

  公开（公告）日：2023-12-14

  Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.