1,1,1-trifluoro-3-(triphenylphosphoranylidene)-2-propanone | 55759-55-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1,1-trifluoro-3-(triphenylphosphoranylidene)-2-propanone
• 英文别名: Trifluoroacetylmethylenetriphenyl phosphorane；Trifluoroacetylmethylenetriphenylphosphorane；Trifluoracetylmethylentriphenylphosphoran；1,1,1-Trifluoro-3-triphenylphosphoranylidene-2-propanone；1,1,1-trifluoro-3-(triphenyl-λ5-phosphanylidene)propan-2-one
• CAS: 55759-55-2
• 化学式: C₂₁H₁₆F₃OP
• 分子量: 372.326
• InChiKey: APSJTTXFGNCJMC-UHFFFAOYSA-N

物化性质

• 熔点：
  230-231 °C(Solv: benzene (71-43-2))
• 沸点：
  445.1±55.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  正丁基锂 、 1,1,1-trifluoro-3-(triphenylphosphoranylidene)-2-propanone 以 乙醚 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  A novel ylide-anion formation resulting from nucleophilic addition. Synthesis of trans-α-trifluoromethyl allylic alcohols

  摘要：

  DOI：

  10.1016/s0040-4039(01)93934-6
• 作为产物：
  描述：

  亚甲基三苯基膦烷 以 四氢呋喃 、 苯 为溶剂， 反应 49.0h， 生成 1,1,1-trifluoro-3-(triphenylphosphoranylidene)-2-propanone
  参考文献：
  名称：

  Phosphinalkylene, 51¹; Synthese und Reaktionen von [1-(Trialkylsilyl)alkyliden]triphenylphosphoranen

  摘要：

  [1-(三烷基硅基)亚烷基三苯基膦的合成与反应] 烷亚基三苯基膦1与三烷基卤硅烷2反应生成了硅烷化的烷亚基膦5，通过三甲基硅基羧酸盐6或羧酸酐10可将其转化为酰化烷亚基膦8和10。自硅烷化的烷亚基膦5与双(三甲基硅基)二羧酸盐12或环状或聚合物酐16，17反应可得到双(酰基烷亚基膦)13-15。

  DOI：

  10.1055/s-1992-26227

文献信息

• [EN] DERIVATIVES OF PYRAZOLINE, PROCEDURE FOR OBTAINING THEM AND USE THEREOF AS THERAPEUTIC AGENTS<br/>[FR] DERIVES DE PYROZOLINE, LEUR PROCEDE D'OBTENTION ET LEUR UTILISATION EN TANT QU'AGENTS THERAPEUTIQUES
  申请人：ESTEVE LABOR DR

  公开号：WO2006011005A1

  公开（公告）日：2006-02-02

  The invention relates to derivatives of general formula (I), and to their pharmaceutically acceptable salts, their stereoisomeric forms, preferably their pure enantiomeric or diastereomeric forms and their racemic forms, or a mixture thereof in any mixture ratio, and their N-oxides and the corresponding solvates or hydrates, to the processes for obtaining said derivatives and to the pharmaceutical compositions which contain them. Said derivatives are useful as anti-inflammatory and analgesic agents. In which R and R1 are different from each other and are selected from H and.

  这项发明涉及通式（I）的衍生物，以及它们的药用盐、立体异构体形式，最好是它们的纯对映体或二对映体形式以及它们的消旋形式，或在任何混合比例中的混合物，以及它们的N-氧化物和相应的溶剂合物或水合物，以及获取这些衍生物的过程以及含有它们的药物组合物。这些衍生物可用作抗炎和镇痛剂。其中R和R1彼此不同，并且选自H。
• Substituted pyrazoline derivatives
  申请人：Altisen Cuberes Rosa

  公开号：US20050182119A1

  公开（公告）日：2005-08-18

  The present invention relates to new substituted pyrazoline compounds, pharmaceutical compositions containing such compounds and the use of these compounds for the treatment of cancer, in particular for the treatment of brain cancer, bone cancer, lip cancer, mouth cancer, esophageal cancer, stomach cancer, liver cancer, bladder cancer, pancreas cancer, ovary cancer, cervical cancer, lung cancer, breast cancer, skin cancer, especially for the treatment of colon cancer and/or bowel cancer and/or prostate cancer.

  本发明涉及新的取代吡唑啉化合物、含有这些化合物的药物组合物以及利用这些化合物治疗癌症的用途，特别是用于治疗脑癌、骨癌、唇癌、口腔癌、食管癌、胃癌、肝癌、膀胱癌、胰腺癌、卵巢癌、宫颈癌、肺癌、乳腺癌、皮肤癌，尤其是用于治疗结肠癌和/或肠癌和/或前列腺癌。
• The Wittig reaction of some fluorinated amide derivatives
  作者：Elliot J. Latham、Steven M. Murphy、Stephen P. Stanforth

  DOI：10.1016/s0040-4039(00)76917-6

  日期：1994.5

  Carboethoxymethylenetriphenylphosphorane 1 reacted with fluorinated amides 4, 6, 8 and 15 yielding products 12, 13, 14 and 3 respectively.

  Carboethoxymethylenetriphenylphosphorane 1用氟化酰胺反应4，6，8和15级得到的产品12，13，14和3分别。
• Dry Etching Gas and Method of Dry Etching
  申请人：Sekiya Akira

  公开号：US20080274334A1

  公开（公告）日：2008-11-06

  A dry etching gas comprising a C 4-6 fluorine compound which has an ether bond or carbonyl group and one or more fluorine atoms in the molecule and is constituted only of carbon, fluorine, and oxygen atoms and in which the ratio of the number of fluorine atoms to the number of carbon atoms (F/C) is 1.9 or lower (provided that the compound is neither a fluorine compound having one cyclic ether bond and one carbon-carbon double bond nor a saturated fluorine compound having one carbonyl group); a mixed dry etching gas comprising the dry etching gas and at least one gas selected from the group consisting of rare gases, O 2 , O 3 , CO, CO 2 , CHF 3 , CH 2 F 2 , CF 4 , C 2 F 6 , and C 3 F 8 ; and a method of dry etching which comprises converting either of these dry etching gases into a plasma and processing a semiconductor material with the plasma. The dry etching gases can be safely used, are reduced in influence on the global environment, and can highly selectively dry-etch a semiconductor material at a high dry etching rate to form a satisfactory pattern shape. The dry etching method employs either of these dry etching gases.

  一种干法刻蚀气体，包括C4-6氟化合物，其具有醚键或羰基基团和分子中的一个或多个氟原子，仅由碳、氟和氧原子构成，其中氟原子与碳原子的比例（F/C）为1.9或更低（前提是该化合物既不是具有一个环状醚键和一个碳-碳双键的氟化合物，也不是具有一个羰基基团的饱和氟化合物）;混合干法刻蚀气体包括干法刻蚀气体和至少一种选自稀有气体、O2、O3、CO、CO2、CHF3、CH2F2、CF4、C2F6和C3F8的气体的气体;以及一种干法刻蚀方法，包括将这些干法刻蚀气体之一转化为等离子体，并用等离子体处理半导体材料。这些干法刻蚀气体可以安全使用，对全球环境的影响减少，并且可以高度选择性地干法刻蚀半导体材料以形成令人满意的图案形状。这种干法刻蚀方法采用这些干法刻蚀气体之一。
• PYRAZOLINE DERIVATIVES, THEIR PREPARATION AND APPLICATION AS MEDICAMENTS
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1083171A1

  公开（公告）日：2001-03-14

  The present invention relates to new pyrazoline derivatives having the general formula (I), as well as to their physiologically acceptable salts, to process in human/veterinary therapy and to pharmaceutical compositions containing them. The new compounds of the invention can be used in the pharmaceutical industry as intermediates and for the preparation of medicaments. In particular, they can be used for the preparation of medicaments used for the treatment of inflammation and other troubles associated to inflammation and other process mediated by cyclooxygenase-2, for example arthritis, pain treatment or fever treatment.

  本发明涉及具有通式（I）的新吡唑啉衍生物及其生理上可接受的盐类、人类/兽医治疗过程以及含有它们的药物组合物。本发明的新化合物可作为中间体用于制药业和制备药物。特别是，它们可用于制备治疗炎症和与炎症有关的其他问题以及环氧化酶-2 介导的其他过程的药物，例如关节炎、疼痛治疗或发烧治疗。