4-Hexylcyclohexylcarbonsaeurechlorid | 73164-24-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: 4-Hexylcyclohexylcarbonsaeurechlorid
• 英文别名: 4-Hexylcyclohexane-1-carbonyl chloride
• CAS: 73164-24-6
• 化学式: C₁₃H₂₃ClO
• 分子量: 230.778
• InChiKey: DOEQWHNUQQMWFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-Hexylcyclohexylcarbonsaeurechlorid 、 左炔诺孕酮 在 thallium (I) ethoxide 作用下， 生成 levonorgestrel trans-4-hexylcyclohexylcarboxylate
  参考文献：
  名称：

  Long-acting contraceptive agents: Design of the who chemical synthesis programme

  摘要：

  The great demand for improved long-acting injectable steroid contraceptives, particularly in developing countries, and the relative lack of interest from the pharmaceutical industry to develop such products stimulated WHO to launch a synthetic and screening programme to find improved, safe and acceptable injectable preparations. More than 210 esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) and levonorgestrel (D-(-)-13 beta-ethyl-17 alpha-ethynyl-17 beta-hydroxygon-4-en-3-one) have been prepared in university-based research laboratories situated mainly in developing countries, and then screened by NICHHD in animal models. The following three compounds, levonorgestrel butanoate, cyclopropylcarboxylate and cyclobutylcarboxylate, proved to be particularly long-acting when administered as microcrystalline suspensions. The overall strategy of this research and development programme is described.

  DOI：

  10.1016/0039-128x(83)90095-8
• 作为产物：
  描述：

  4-n-hexylcyclohexanecarboxylic acid 生成 4-Hexylcyclohexylcarbonsaeurechlorid
  参考文献：
  名称：

  NODA, KANDZI;NAKAGAVA, NOBORU;MOTOMURA, TOSIXARU;SIMODZONO, YUDZI;IIDEH, +

  摘要：

  DOI：

文献信息

• Tetrahydroxybenzene tetraester derivative and polymer thereof
  申请人：Shundo Ryushi

  公开号：US20060180791A1

  公开（公告）日：2006-08-17

  The invention includes compounds represented by Formula (1): wherein R 1 is an alkyl having 1 to 20 carbon atoms; A 1 and A 2 are a 1,4-cyclohexylene or 1,4-phenylene; X is a single bond, —C≡C—, —COO—, —OCO—, —CH═CH—COO— or —OCO—CH═CH—; P is an alkylene having 1 to 20 carbon atoms; and p and q are 0, 1 or 2.

  该发明包括以下式子所表示的化合物：其中，R1是具有1至20个碳原子的烷基；A1和A2是1,4-环己基或1,4-苯基；X是单键，—C≡C—，—COO—，—OCO—，—CH═CH—COO—或—OCO—CH═CH—；P是具有1至20个碳原子的烷基；p和q为0、1或2。
• Ivaschenko, A. V.; Lazareva, V. T.; Prudnikova, E. K., Molecular Crystals and Liquid Crystals (1969-1991), 1985, vol. 129, p. 259 - 266
  作者：Ivaschenko, A. V.、Lazareva, V. T.、Prudnikova, E. K.、Rumyantsev, V. G.、Titov, V. V.

  DOI：——

  日期：——
• Ivashchenko, A.; Lazareva, V.; Prudnikova, E., Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1992, vol. 213, p. 133 - 136
  作者：Ivashchenko, A.、Lazareva, V.、Prudnikova, E.、Rumyantsev, V.、Titov, V.

  DOI：——

  日期：——
• Schaefer, W.; Rosenfeld, U.; Zaschke, H., Journal fur praktische Chemie (Leipzig 1954), 1989, vol. 331, # 4, p. 631 - 636
  作者：Schaefer, W.、Rosenfeld, U.、Zaschke, H.、Stettin, H.、Kresse, H.

  DOI：——

  日期：——
• SIONODZAKI, JOSITAKEH
  作者：SIONODZAKI, JOSITAKEH

  DOI：——

  日期：——