Dimethyl 2-morpholinosuccinate | 61533-02-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Dimethyl 2-morpholinosuccinate
• 英文别名: dimethyl 2-morpholin-4-ylbutanedioate
• CAS: 61533-02-6
• 化学式: C₁₀H₁₇NO₅
• mdl: MFCD06738260
• 分子量: 231.249
• InChiKey: ARVIASYJDUUECD-UHFFFAOYSA-N

物化性质

• 沸点：
  321.4±42.0 °C(Predicted)
• 密度：
  1.172±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  65.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  L-苹果酸二甲酯 在 dipotassium hydrogenphosphate 作用下， 以 乙酸乙酯 为溶剂， 反应 1.5h， 生成 Dimethyl 2-morpholinosuccinate
  参考文献：
  名称：

  通过异脲中间体对醇进行机械化学亲核取代**

  摘要：

  更环保的胺合成：首次提出了在机械化学单罐反应条件下通过反应性异脲盐对醇进行的亲核取代。该方法打开了获得生物活性胺的途径，包括活性药物成分。

  DOI：

  10.1002/cssc.202102286

文献信息

• Synthesis of a crosslinked polymer with a benzyl(triphenyl)phosphonium ionic liquid moiety and its catalytic activity
  作者：Xuezheng Liang

  DOI：10.1039/c5ra18507f

  日期：——

  A novel crosslinked polymer with a benzyl(triphenyl)phosphonium ionic liquid moiety was synthesized from triphenylphosphine and p-xylylene dichloride. The bulky IL molecules were inlaid in the polymeric framework, which avoided pore blocking and IL moiety release. The polymer had a high BET surface area and accessible active sites. The polymer was applied to catalyze the aza-Michael additions and gave

  由三苯基膦和对二甲苯二氯合成了具有苄基（三苯基）phosph离子液体部分的新型交联聚合物。庞大的IL分子镶嵌在聚合物骨架中，避免了孔阻塞和IL部分释放。该聚合物具有高的BET表面积和可及的活性位点。将该聚合物用于催化氮杂-迈克尔加成反应，并在几分钟内平均收率超过95.0％。该聚合物具有多个优点，例如高BET表面积，高活性和高稳定性，为绿色化学过程提供了巨大潜力。
• Facile Approach to Natural or Non-Natural Amino Acid Derivatives: Me₃SiCl-Promoted Coupling Reaction of Organozinc Compounds with N,O-Acetals
  作者：Norio Sakai、Junichi Asano、Yuki Kawada、Takeo Konakahara

  DOI：10.1002/ejoc.200801107

  日期：2009.2

  We have developed a Me3SiCl-promoted coupling reaction of aryl- and alkylzinc compounds, in-situ generated either by transmetalation of the corresponding organometallic reagents or by insertion of zinc metal into organic halides, with several N,O-acetals, which leads to the preparation of a variety of natural and non-natural amino acid derivatives. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim

  我们开发了一种 Me3SiCl 促进的芳基和烷基锌化合物的偶联反应，通过相应的有机金属试剂的金属转移或通过将锌金属插入有机卤化物中而原位生成，与几种 N，O-缩醛，这导致制备多种天然和非天然氨基酸衍生物。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
• NITROGEN CONTAINING HYDROFLUOROETHERS AND METHODS OF MAKING SAME
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US20160145195A1

  公开（公告）日：2016-05-26

  Provided are amine-containing hydrofluoroether compounds represented by the following general formula (I), wherein (I) Y is a single bond or CF2 and wherein (i) Rf.1 and Rf2 are independently linear or branched perfluoroalkyl groups having with 1-8 carbon atoms and optionally comprise at least one catenated heteroatom, or (ii) Rf1 and Rf2 are bonded together to form a ring structure having 4-6 carbon atoms and optionally comprise one or more catenated heteroatoms; with the proviso that if Rf1 and Rf2 are bonded together to form a ring structure comprising a nitrogen heteroatom, said nitrogen heteroatom is tertiary and is bonded to a perfluoroalkyl group having 1-3 carbon atoms.

  提供的是含有胺基的氢氟醚化合物，其通式如下（I），其中（I）Y是单键或CF2，其中（i）Rf.1和Rf2是独立的线性或支链全氟烷基，具有1-8个碳原子，且可选地包含至少一个串联杂原子，或（ii）Rf1和Rf2结合在一起形成一个环状结构，具有4-6个碳原子，且可选地包含一个或多个串联杂原子；但是，如果Rf1和Rf2结合在一起形成一个含有氮杂原子的环状结构，则该氮杂原子是三级的，并与具有1-3个碳原子的全氟烷基结合。
• US9540316B2
  申请人：——

  公开号：US9540316B2

  公开（公告）日：2017-01-10
• [EN] NITROGEN CONTAINING HYDROFLUOROETHERS AND METHODS OF MAKING SAME<br/>[FR] HYDROFLUOROÉTHERS CONTENANT DE L'AZOTE ET PROCÉDÉS POUR LEUR PRÉPARATION
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2015013155A1

  公开（公告）日：2015-01-29

  Provided are amine-containing hydrofluoroether compounds represented by the following general formula (I), wherein (I) Y is a single bond or CF2 and wherein (i) Rf.1 and Rf2 are independently linear or branched perfluoroalkyl groups having with 1-8 carbon atoms and optionally comprise at least one catenated heteroatom, or (ii) Rf1 and Rf2 are bonded together to form a ring structure having 4-6 carbon atoms and optionally comprise one or more catenated heteroatoms; with the proviso that if Rf1 and Rf2 are bonded together to form a ring structure comprising a nitrogen heteroatom, said nitrogen heteroatom is tertiary and is bonded to a perfluoroalkyl group having 1-3 carbon atoms.