羟基硬脂酸辛酯 | 29710-25-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 羟基硬脂酸辛酯
• 中文别名: 12-羟基硬脂酸-2-乙基己酯；羟基硬脂酸乙基己酯
• 英文名称: 2-ethylhexyl 12-hydroxystearate
• 英文别名: octyl hydroxystearate；12-hydroxy-octadecanoic acid-(2-ethyl-hexyl ester)；12-Hydroxy-octadecansaeure-(2-aethyl-hexylester)；12-Hydroxy-stearinsaeure-(2-aethyl-hexylester)；2-ethylhexyl 12-hydroxyoctadecanoate；2-ethylhexyl-12-hydroxy stearate；Octadecanoic acid, 12-hydroxy-, 2-ethylhexyl ester
• CAS: 29710-25-6；29383-26-4
• 化学式: C₂₆H₅₂O₃
• 分子量: 412.697
• InChiKey: GLCFQKXOQDQJFZ-UHFFFAOYSA-N

物化性质

• 沸点：
  455.93℃[at 101 325 Pa]
• 密度：
  0.889[at 20℃]
• LogP：
  10.06
• 物理描述：
  Liquid

计算性质

• 辛醇/水分配系数(LogP)：
  9.8
• 重原子数：
  29
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2918199090

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 镍 作用下， 140.0 ℃ 、980.59 kPa 条件下， 生成 羟基硬脂酸辛酯
  参考文献：
  名称：

  US2397008

  摘要：

  公开号：

文献信息

• Pharmaceutical compositions for transdermal administration of anti-inflammatory agents
  申请人：——

  公开号：US20030152611A1

  公开（公告）日：2003-08-14

  The invention concerns a pharmaceutical composition for transdermal administration comprising: a polymeric release matrix capable of forming a soft film after drying, selected among cellulose polymers or copolymers, said matrix being present at a concentration not exceeding 6% of the composition weight; an active principle selected among the group of non-steroid anti-inflammatory agents comprising at least a metal carboxylic or carboxitate group; a transcutaneous absorption promoter of the active principle; water; and at least a physiologically acceptable non-aqueous solvent capable of dissolving the release matrix, the active principle and transcutaneous absorption promoter and to be rapidly eliminated by evaporation in contact with the skin.

  该发明涉及一种用于经皮给药的制药组合物，包括：一种聚合物释放基质，能够在干燥后形成软膜，所述基质从纤维素聚合物或共聚物中选择，所述基质的浓度不超过组合物重量的6％；选择自非甾体抗炎药物组中的活性成分，该组成分至少包括一种金属羧基或羧酸盐基团；活性成分的经皮吸收促进剂；水；以及至少一种生理上可接受的非水溶剂，能够溶解释放基质、活性成分和经皮吸收促进剂，并在与皮肤接触时通过蒸发迅速被消除。
• Pharmaceutical composition for transdermal administration
  申请人：Sanofi

  公开号：US06010716A1

  公开（公告）日：2000-01-04

  The invention concerns a pharmaceutical composition for transdermal administration, characterized in that it comprises: a) optionally, a polymeric release matrix capable of forming a flexible film after drying, chosen from cellulose polymers or copolymers or vinylpyrrolidone/vinyl acetate copolymers b) an active principle c) a promoter of transcutaneous absorption of the active principle d) a physiologically acceptable non-aqueous solvent capable of dissolving the release matrix, the active principle and the transcutaneous absorption promoter and also capable of being rapidly removed by evaporation on contact with the skin.

  本发明涉及一种用于经皮给药的药物组合物，其特征在于它包括：a）可选的聚合物释放基质，能够在干燥后形成柔性薄膜，选择自纤维素聚合物或共聚物或乙烯基吡咯烷酮/醋酸乙烯酯共聚物；b）活性成分；c）促进活性成分经皮吸收的促进剂；d）生理上可接受的非水溶剂，能够溶解释放基质、活性成分和经皮吸收促进剂，并且在接触皮肤时能够通过蒸发迅速去除。
• Prostaglandin and hydroxylated fatty acid ester formulations
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0112451A2

  公开（公告）日：1984-07-04

  Degradation of E-type prostaglandin compounds is retarded by dissolving or suspending such compounds in formulations containing hydroxylated derivatives of fatty acids having the formula: wherein R1 is C2-C24 alkyl, R2 is C2-C24 alkyl and n is an integer from 1-6, denoting from to 6 hydroxyl groups which may be substituted in R, or R2.

  将 E 型前列腺素化合物溶解或悬浮在含有脂肪酸羟基化衍生物的制剂中，可以延缓 E 型前列腺素化合物的降解，脂肪酸羟基化衍生物的分子式为： 其中 R1 为 C2-C24 烷基，R2 为 C2-C24 烷基，n 为 1-6 之间的整数，表示 R 或 R2 中可被取代的羟基数为 6。
• Cleansing agents
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP1129686A1

  公开（公告）日：2001-09-05

  Providing cleansing agents which are highly effective for removing makeup with excellent lathering and give refreshing after-shampoo feelings. The cleansing agents comprises surfactants and polyoxyalkylene carboxylic acid ester represented by the following general formula (1); wherein R1 and R2 are hydrogen or alkyl or branched alkyl groups of 1 to 4 carbon atoms; m, n, X and Y are integers from 0 to 5 but are not concurrently 0; and R3 is a branched or straight alkylene group of 0 to 10 carbon atoms.

  提供高效卸妆、泡沫丰富、洗发后感觉清爽的清洁剂。该清洁剂由表面活性剂和聚氧亚烷基羧酸酯组成，由以下通式（1）表示； 其中 R1 和 R2 为氢或 1 至 4 个碳原子的烷基或支链烷基；m、n、X 和 Y 为 0 至 5 的整数，但不同时为 0；R3 为 0 至 10 个碳原子的支链或直链亚烷基。
• Compositions for controlling phytoplankton contamination
  申请人：BLUEGREEN WATER TECHNOLOGIES LTD.

  公开号：US11154053B2

  公开（公告）日：2021-10-26

  A composition for mitigating, inhibiting, ameliorating and/or eliminating phytoplankton growth in a waterbody, the composition comprising an active ingredient at concentration of 80.0-99.5% (w/w) of the composition and a coating material at concentration of 0.5-20% (w/w) of the composition; wherein the critical surface tension of the composition is between 15-60 dyn/cm and wherein the relative density of the composition, prior to being submerged in water, is above 1 g/cm3.

  一种用于减轻、抑制、改善和/或消除水体中浮游植物生长的组合物，该组合物包括浓度为组合物 80.0-99.5%（重量/重量）的活性成分和浓度为组合物 0.5-20%（重量/重量）的涂层材料；其中，组合物的临界表面张力在 15-60 达因/厘米之间，组合物在浸入水中之前的相对密度高于 1 克/立方厘米。