α,α-dibromo-o-xylene | 79985-01-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α,α-dibromo-o-xylene
• 英文别名: 2-methylbenzyl bromide；o-dibromoxylene；o-xylene dibromide；1-(Dibromomethyl)-2-methylbenzene
• CAS: 79985-01-6
• 化学式: C₈H₈Br₂
• 分子量: 263.96
• InChiKey: QSSAZDNARJWYEF-UHFFFAOYSA-N

物化性质

• 熔点：
  95-96 °C
• 沸点：
  95 °C(Press: 6.74 Torr)
• 密度：
  1.769±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  α,α-dibromo-o-xylene 在 二溴亚砜 作用下， 反应 1.5h， 以11.1 g的产率得到1-溴甲基-2-二溴甲基苯
  参考文献：
  名称：

  Saraf, S. D., Synthetic Communications, 1983, vol. 13, # 1, p. 7 - 14

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基苯甲醛 在 三溴化硼 作用下， 以 氯仿 为溶剂， 以57%的产率得到α,α-dibromo-o-xylene
  参考文献：
  名称：

  Photolysis of a series of α-brominated ortho-xylenes in apolar solvents

  摘要：

  The alpha-brominated ortho-xylenes have been subjected to 254-nm irradiation in deaerated benzene, isooctane and benzene-cyclohexene. The product analysis revealed that homolysis of the C-Br bond is followed by a series of hydrogen abstraction and radical recombination reactions resulting in xylenes more and less brominated than the starting compound. The less brominated products are formed with higher quantum yield when cyclohexene is present, due to hydrogen abstraction by the o-benzyl radical formed initially, together with cyclohexene dimers. Additionally, the formation of 2-bromo-2,4,4-trimethylpentane is observed when isooctane is the solvent. The quantum yields observed for the photolysis of 1 and 2 are higher in benzene than in isooctane, suggesting sensitization by benzene. A biradical intermediate of the type o-quinodimethane was expected in the case of (a) photolysis of the o-benzyl radical formed (biphotonic process) or (b) intramolecular hydrogen abstraction. However, the addition of cyclohexene failed to produce the expected Diels-Alder adduct; The synthesis of the novel alpha,alpha-dibromo-o-xylene 3 is reported.

  DOI：

  10.1039/p29950001857

文献信息

• Biaryl-methanethio-, -sulphinyl- and sulphonyl derivatives
  申请人：CEPHALON, INC.

  公开号：EP1586559A1

  公开（公告）日：2005-10-19

  FIELD OF THE INVENTION The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that include substituted biaryl-methanesulfinyl acetamides of Formula (I): wherein Ar, Y, R1, R2, R4, R5, q and x are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness associated with narcolepsy, obstructive sleep apnea, or shift work disorder; Parkinson's disease; Alzheimer's disease; attention deficit disorder; attention deficit hyperactivity disorder; depression; or fatigue associated with a neurological disease; as well as the promotion of wakefulness.

  本发明涉及化学组合物、其制备方法以及组合物的用途。特别是，本发明涉及包括式（I）的取代联苯基-甲磺酰基乙酰胺的组合物： 其中Ar、Y、R1、R2、R4、R5、q和x如本文所定义；以及它们在治疗疾病中的用途，包括治疗与嗜睡症、阻塞性睡眠呼吸暂停或倒班工作障碍相关的嗜睡症、帕金森病、阿尔茨海默病、注意力缺陷障碍、注意力缺陷多动障碍、抑郁症或与神经系统疾病相关的疲劳，以及促进清醒。
• Novel carbapenem derivatives of quarternary salt type
  申请人：——

  公开号：US20030022881A1

  公开（公告）日：2003-01-30

  An objective of the present invention is to provide carbapenem derivatives which have potent antibiotic activity against MRSA, PRSP, Influenzavirus, and &bgr;-lactamase-producing bacteria and are stable against DHP-1. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts thereof: 1 wherein R 1 represents H or methyl; R 2 and R 3 each independently represent H, halogen, lower alkyl or the like; R 4 represents optionally substituted lower alkylthio or the like; and R 5 represents optionally substituted lower alkyl or the like.

  本发明的目的在于提供对MRSA、PRSP、流感病毒和β-内酰胺酶产生菌具有强大抗生素活性的碳青霉烯衍生物，且对DHP-1稳定。根据本发明的化合物是由公式(I)表示的化合物或其药物可接受的盐：1其中R1代表H或甲基；R2和R3各自独立地代表H、卤素、低级烷基等；R4代表可选地取代的低级烷基亚磺酰基等；R5代表可选地取代的低级烷基等。
• A Scalable Procedure for Light-Induced Benzylic Brominations in Continuous Flow
  作者：David Cantillo、Oscar de Frutos、Juan A. Rincon、Carlos Mateos、C. Oliver Kappe

  DOI：10.1021/jo402409k

  日期：2014.1.3

  A continuous-flow protocol for the bromination of benzylic compounds with N-bromosuccinimide (NBS) is presented. The radical reactions were activated with a readily available household compact fluorescent lamp (CFL) using a simple flow reactor design based on transparent fluorinated ethylene polymer (FEP) tubing. All of the reactions were carried out using acetonitrile as the solvent, thus avoiding

  提出了使用N-溴代琥珀酰亚胺（NBS）溴化苄基化合物的连续流程方案。使用基于透明氟化乙烯聚合物（FEP）管的简单流式反应器设计，使用易于获得的家用紧凑型荧光灯（CFL）激活自由基反应。所有反应均使用乙腈作为溶剂进行，从而避免使用有害的氯化溶剂，例如CCl 4。对于每种底物，仅需要1.05当量的NBS即可将苄基原料完全转化为相应的溴化物。通过溴化一组包含不同官能团的19种底物，证明了该方法的一般特征。在所有情况下均获得了良好的分离效果。通过使反应器运行更长的时间（吞吐量为30 mmol h –1），可以很容易地将新的流量规程缩放到几克数量，这在分批光化学反应器中不容易实现。溴化方案也可以在更大流量的反应器中使用功率更大的灯以相同的效率执行。以苯丙酮溴化为模型，所需溴化物的产率为180 mmol h –1。
• [EN] METHODS AND COMPOSITIONS FOR TARGETED THERAPEUTICS<br/>[FR] MÉTHODES ET COMPOSITIONS POUR UN USAGE THÉRAPEUTIQUE CIBLÉ
  申请人：MEDIVATION TECHNOLOGIES INC

  公开号：WO2017019830A1

  公开（公告）日：2017-02-02

  This disclosure describes compositions and methods for delivering and localizing repair cells to therapeutic targets.

  这份披露描述了将修复细胞传递和定位到治疗靶点的组合物和方法。
• [EN] METHODS AND COMPOSITIONS USING REPAIR CELLS AND CATIONIC DYES<br/>[FR] MÉTHODES ET COMPOSITIONS UTILISANT DES CELLULES RÉPARATRICES ET DES COLORANTS CATIONIQUES
  申请人：MEDIVATION TECHNOLOGIES INC

  公开号：WO2017019832A1

  公开（公告）日：2017-02-02

  This disclosure describes compositions and methods for delivering and localizing repair cells to therapeutic targets.

  这份披露描述了将修复细胞传递和定位到治疗靶点的组合物和方法。

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