N-[N-[3-(4-methoxyphenyl) propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester | 245650-21-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[N-[3-(4-methoxyphenyl) propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester
• 英文别名: (3S)-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-3-[3-(4-methoxyphenyl)propylamino]-4-oxobutanoic acid
• CAS: 245650-21-9
• 化学式: C₂₄H₃₀N₂O₆
• 分子量: 442.512
• InChiKey: LROYFWOHPXYWBM-SFTDATJTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  32
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-甲氧基肉桂醛 、 阿斯巴甜 在 palladium-carbon 作用下， 以 甲醇 、 水 、 乙酸乙酯 为溶剂， 以43.4%的产率得到N-[N-[3-(4-methoxyphenyl) propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester
  参考文献：
  名称：

  EP1221448

  摘要：

  公开号：

文献信息

• Sweetener compositions and uses thereof
  申请人：AJINOMOTO CO. INC

  公开号：US20040105928A1

  公开（公告）日：2004-06-03

  The present invention provides compositions containing one or more aspartyl dipeptide derivatives represented by formulas (1) and/or (2) mixed with another high intensity sweetner, such Aspartame, sugar, sugar alcohol, and oligosaccharide; food, beverages, and/or medicinal products containing these compositions, methods of using the compositions to impart sweetness in food, beverages, and/or medicinal products to impart sweetness or suppress a bitter taste; and methods of making the compositions and products.

  本发明提供了一种含有一个或多个由式(1)和/或式(2)表示的天冬氨酰二肽衍生物与另一种高强度甜味剂混合的组合物；含有这些组合物的食品、饮料和/或药品；使用这些组合物在食品、饮料和/或药品中赋予甜味或抑制苦味的方法；以及制备这些组合物和产品的方法。其中，另一种高强度甜味剂可以是阿斯巴甜、糖、糖醇和寡糖。
• ASPARTYL DIPEPTIDE ESTER DERIVATIVES AND SWEETENERS
  申请人：Ajinomoto Co., Inc.

  公开号：EP1070726A1

  公开（公告）日：2001-01-24

  Novel aspartyl dipeptide ester derivatives (including salts thereof) having an excellent sweetening effect and usable as sweeteners such as N-[N-[3-(3-methyl-4-hydroxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester and N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester, and excellent sweeteners,etc. containing these novel derivatives are provided. A low-calory sweetener having especially an excellent sweetening potency can be provided in comparison with conventional ones.

  新型天冬氨酰二肽酯衍生物（包括其盐）具有极佳的甜味效果，可用作甜味剂，如 N-[N-[3-(3-甲基-4-羟基苯基)丙基]-L-α-天冬氨酰]-L-苯丙氨酸 1-甲酯和 N-[N-[3-(3-羟基-4-甲氧基苯基)丙基]-L-α-天冬氨酰]-L-苯丙氨酸 1-甲酯，以及极佳的甜味剂等。提供了含有这些新型衍生物的优良甜味剂等。 与传统甜味剂相比，这种低热量甜味剂的甜味效果尤其出色。
• SWEETENER COMPOSITIONS WITH HIGH DEGREE OF SWEETNESS HAVING IMPROVED SWEETNESS, CORRIGENTS AND UTILIZATION THEREOF
  申请人：Ajinomoto Co., Inc.

  公开号：EP1221448A1

  公开（公告）日：2002-07-10

  A sweetener composition with a high intense sweetness having a sweetness quality which is closer to that of sucrose, obtained by blending aspartyl dipeptide ester derivatives which are sweetener components with a high intense sweetness such as N-[N-[3-(3-hydroxy-4-methoxyphenyl) propyl]-L-α-aspartyl]-L-phenylalanine 1-methyl ester, with anther sweetener components with a high intense sweetness such as Aspartame, or at least one of the compounds contained in the group consisting of sugar, sugar alcohol and oligosaccharides so as to strengthen the onset of the taste of said derivatives and weaken the lingering taste, thereby improving the balance of the onset of the taste and the lingering taste, is provided. Further, said aspartyl dipeptide ester derivatives can be used as taste modifiers. By using these taste modifiers, an effect of highly eliminating or repressing a bitter taste can be achieved and maintained, without undesirable effect for the physical properties of compositions such as food and drink and medicines, in particular, viscosity and so on of liquid compositions, or degradation of qualities such as browning during storage. Thus, food and drink and medicines and so on of a preferable taste quality with the improved bitter taste can be provided.

  一种具有高强度甜味的甜味剂组合物，其甜味质量更接近蔗糖的甜味质量，该甜味剂组合物是通过将天冬氨酰二肽酯衍生物与 N-[N-[3-(3-羟基-4-甲氧基苯基)丙基]-L-α-天冬氨酰]-L-苯丙氨酸 1-甲酯等具有高强度甜味的甜味剂成分混合而获得的、本发明还提供了具有高甜度的甜味剂成分，如阿斯巴甜，或至少一种由糖、糖醇和低聚糖组成的组中所含的化合物，以增强所述衍生物的起始味道并减弱余味，从而改善起始味道和余味的平衡。 此外，所述天冬氨酰二肽酯衍生物可用作味道调节剂。通过使用这些味道调节剂，可以达到并保持高度消除或抑制苦味的效果，同时不会对食品、饮料和药品等组合物的物理性质，特别是液体组合物的粘度等产生不良影响，也不会在贮存期间出现褐变等品质退化现象。因此，可以提供具有改善的苦味的优质食品、饮料和药品等。
• SOLID SWEETENER COMPOSITIONS, LIQUID SWEETENER COMPOSITIONS AND UTILIZATION THEREOF
  申请人：Ajinomoto Co., Inc.

  公开号：EP1223175A1

  公开（公告）日：2002-07-17

  Solid compositions of sweetener with a high intense sweetness (including those in the form of solid food) having a sweetness quality with homogeneous dispersion in the whole, which comprise an aspartyl dipeptide ester derivatives such as N-[N-[3-(3-hydroxy-4-methoxyphenyl) propyl] -L-α-aspartyl]-L-phenylalanine 1-methyl ester which is a sweetener with a high intense sweetness (one kind or more; which may be in the salt form), and a filler (including a bulking agent, a carrier and so on), particularly at least one of the compounds contained in the group consisting of sugar , sugar alcohol, oligosaccharide and polysaccharide, and are produced by a process involving the step of mixing at least said derivative(s) in the form of solution during manufacture, are provided. Solutions or suspensions with a high intense sweetness, stably over a long period of time, which are obtained by mixing at least one kind of said aspartyl dipeptide ester derivative having a high intense sweetness in an edible medium, preferably together with at least one of the compounds contained in the group consisting of sugar, sugar alcohol and oligosaccharide as a stabilizer, and homogeneously dissolving or suspending, are provided. These solutions and so on are useful as sweeteners, and for imparting sweetness to food and drink which are added sweetness or the product in need of sweetness. Liquid compositions of sweetener with a high intense sweetness, which are stable over a long period of time, excellent in solubility and workability without undergoing scattering, can be obtained.

  高甜度甜味剂的固体组合物（包括固体食品形式的组合物），其甜度质量在整体上均匀分散，其中包括天冬氨酰二肽酯衍生物，如 N-[N-[3-(3-羟基-4-甲氧基苯基)丙基]-L-α-天冬氨酰]-L-苯丙氨酸 1-甲酯，它是一种高甜度甜味剂（一种或多种；本发明提供了一种具有高甜度的甜味剂（一种或多种；可以是盐形式）和一种填料（包括膨松剂、载体等），特别是由糖、糖醇、低聚糖和多糖组成的组中所含的至少一种化合物，其生产工艺包括在制造过程中以溶液形式混合至少上述衍生物的步骤。 本发明还提供了具有高甜度、长期稳定的溶液或悬浮液，这些溶液或悬浮液是通过将至少一种具有高甜度的上述天冬氨酰二肽酯衍生物与糖类、糖醇和寡糖组成的化合物组中的至少一种作为稳定剂混合在可食用介质中，并均匀溶解或悬浮而得到的。这些溶液等可用作甜味剂，也可用于向添加甜味剂的食品和饮料或需要甜味剂的产品中添加甜味剂。可以获得具有高强度甜味的甜味剂液体组合物，这种组合物在长时间内保持稳定，溶解性和加工性极佳，不会发生分散。
• Sweetener compositions containing aspartyl dipeptide ester compounds
  申请人：AJINOMOTO CO. INC

  公开号：US20030044502A1

  公开（公告）日：2003-03-06

  The present invention provides solid and liquid sweetening compositions with a high intensity sweetness containing aspartyl dipeptide ester compounds, processing of making the aspartyl dipeptide ester compounds, as well as food and beverages containing the compositions.

  本发明提供了含有天冬氨酰二肽酯化合物的高甜度固体和液体甜味剂组合物、天冬氨酰二肽酯化合物的制造工艺以及含有该组合物的食品和饮料。