Medifoxamine fumarate | 16604-45-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Medifoxamine fumarate
• 英文别名: Cledial；N,N-Dimethyl-2,2-diphenoxy-ethylamin-hydrogenfumarat；2,2-diphenoxyethyl(dimethyl)ammonium fumarate (1:1)；(E)-but-2-enedioic acid;N,N-dimethyl-2,2-diphenoxyethanamine
• CAS: 16604-45-8
• 化学式: C₄H₄O₄*C₁₆H₁₉NO₂
• 分子量: 373.406
• InChiKey: CSQUJXBMSDQIKM-WLHGVMLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.74
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  96.3
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Compositions and methods for the treatment of pain
  申请人：GM Pharmaceuticals, Inc.

  公开号：US10987365B2

  公开（公告）日：2021-04-27

  The claimed invention relates to compositions that may be in a form of a liquid, solid, gel, cream or gel capsule comprising an analgesic, and methods for administering these compositions for treatment of patients suffering from various forms of pain.

  本发明涉及可为液体、固体、凝胶、乳膏或凝胶胶囊形式的包含镇痛剂的组合物，以及使用这些组合物治疗各种形式疼痛患者的方法。
• PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF
  申请人：Pediamed Pharmaceuticals, Inc.

  公开号：EP1641446A1

  公开（公告）日：2006-04-05
• Pharmaceutical compositions including an antihistamine and a stimulant and method of use thereof
  申请人：PediaMed Pharmaceuticals, Inc.

  公开号：US20040259809A1

  公开（公告）日：2004-12-23

  The present invention provides pharmaceutical compositions including a sedating antihistamine and a stimulant, and methods of use thereof. The stimulant reduces the sedation caused by the antihistamine, thereby allowing potent, but sedating, antihistamines to be used effectively.
• PERSONALIZED PHARMACEUTICAL KITS, PACKAGING AND COMPOSITIONS FOR THE TREATMENT OF ALLERGIC CONDITIONS
  申请人：Du Jie

  公开号：US20090325999A1

  公开（公告）日：2009-12-31

  This invention relates to personalized pharmaceutical kits, packaging, compositions, and methods for treatment of a mammal, comprising at least one antihistamine for treating an allergic disease or condition in a mammal, in combination with at least one wakefulness promoting agent for preventing sedative effects during day time use, while promoting the antihistamine and sedating effect during evening use.
• PHARMACEUTICAL COMPOSITIONS
  申请人：Mitchell Odes W.

  公开号：US20130210835A1

  公开（公告）日：2013-08-15

  A composition of an antitussive, a decongestant, or an antihistamine to treat respiratory and oral pharyngeal congestion and related symptoms in a patient.