5-(methylthio)thiophene-2-carboximidamide hydrochloride | 1621363-56-1

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 5-(methylthio)thiophene-2-carboximidamide hydrochloride
• 英文别名: 5-methylsulfanylthiophene-2-carboximidamide;hydrochloride
• CAS: 1621363-56-1
• 化学式: C₆H₈N₂S₂*ClH
• 分子量: 208.736
• InChiKey: BCWPEPLUHHZPDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.18
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  103
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(methylthio)thiophene-2-carboximidamide hydrochloride 在 potassium carbonate 、 caesium carbonate 、 三氯氧磷 作用下， 以 水 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 76.0h， 生成 methyl 2-(4-((2-(5-(methylthio)thiophen-2-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate
  参考文献：
  名称：

  [EN] NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS
  [FR] NOUVEAUX COMPOSÉS PYRIMIDINES CONDENSÉS SUBSTITUÉS

  摘要：

  该发明涉及一种新型的取代的紧缩嘧啶化合物，其一般式为（I），其中化学基团、取代基和指数如描述中所定义，并且用作药物，特别是用作治疗可以通过抑制PDE4酶来治疗的病况和疾病的药物。

  公开号：

  WO2014117948A1

文献信息

• NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS
  申请人：GRÜNENTHAL GMBH

  公开号：US20150344496A1

  公开（公告）日：2015-12-03

  The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.

  本发明涉及一种新型的取代紧缩嘧啶化合物，其一般式为(I)，其中化学基团、取代基和指数如描述中所定义，并且涉及其作为药物的用途，特别是作为治疗可以通过抑制PDE4酶来治疗的疾病和病症的药物。
• US9670189B2
  申请人：——

  公开号：US9670189B2

  公开（公告）日：2017-06-06
• [EN] METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR<br/>[FR] METHODES DE TRAITEMENT DE MALADIES ET PATHOLOGIES INDUITES PAR C1s, COMPOSES ET COMPOSITIONS PREPARES A CET EFFET
  申请人：——

  公开号：WO2000047194A9

  公开（公告）日：2001-05-31

  [EN] Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, like inflammation, sepsis, tissue damage, autoimmune disorders, adult respiratory distress syndrome, hemolytic anemia, myasthenia gravis, immune complex induced vasculitis, glomerulonephritis, arthritis, allergic neuritis, graves disease, insulin resistance, systemic lupus erythematosus, graft rejection, neurodegenerative diseases including Alzheimer's disease, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R<1>, R<2>, R<3>, R<4>, X, Y and Z are defined in the specification.
  [FR] L'invention concerne une méthode de traitement des symptômes d'une pathologie aiguë ou chronique, induite par le mécanisme d'action classique de la cascade du complément, consistant à administrer à un mammifère nécessitant un tel traitement, une dose efficace sur le plan thérapeutique d'un composé correspondant à la formule (I), ou d'un solvate, hydrate ou sel de celui-ci, acceptable sur le plan pharmacologique. Dans cette formule, R<1>, R<2>, R<3>, R<4>, X, Y et Z possèdent les notations données dans la description.
• FLUORINE-CONTAINING PYRIMIDINE COMPOUND AND METHOD FOR PRODUCING SAME
  申请人：UNIMATEC CO., LTD.

  公开号：US20240124436A1

  公开（公告）日：2024-04-18

  A fluorine-containing pyrimidine compound represented by formula (1), (2) or (3) is provided: wherein in formulae (1) to (3), R represents a hydrocarbon group having 1 to 12 carbon atoms, X and Y each independently represent a hydrogen atom, a halogen atom, a hydrocarbon group having 1 to 10 carbon atoms, —C n F 2n+1 , a nitro group, a boronic acid group, —OA 1 , —SO m A 1 , —NA 1 A 2 , —COOA 1 or —CONA 1 A 2 , Z represents CW or N, W represents a hydrogen atom, a halogen atom, a hydrocarbon group having 1 to 10 carbon atoms, —C n F 2n+1 , a nitro group, a boronic acid group, —OA 1 , —SO m A 1 , —NA 1 A 2 , —COOA 1 or —CONA 1 A 2 , n is an integer of 1 to 10 and m is an integer of 0 to 3, and A 1 and A 2 each independently represent a hydrogen atom or a hydrocarbon group having 1 to 10 carbon atoms.
• [EN] NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS PYRIMIDINES CONDENSÉS SUBSTITUÉS
  申请人：GRUENENTHAL GMBH

  公开号：WO2014117948A1

  公开（公告）日：2014-08-07

  The invention relates to novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.

  该发明涉及一种新型的取代的紧缩嘧啶化合物，其一般式为（I），其中化学基团、取代基和指数如描述中所定义，并且用作药物，特别是用作治疗可以通过抑制PDE4酶来治疗的病况和疾病的药物。