p-phenoxycinnamic acid | 2215-83-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-phenoxycinnamic acid
• 英文别名: 3-(4-Phenoxy-phenyl)-acrylsaeure；3-<4-Phenoxy-phenyl>-acrylsaeure；4-Phenoxycinnamic acid；3-(4-phenoxyphenyl)prop-2-enoic acid
• CAS: 2215-83-0
• 化学式: C₁₅H₁₂O₃
• 分子量: 240.258
• InChiKey: XWGDODCEQXQAFQ-UHFFFAOYSA-N

物化性质

• 熔点：
  155-157 °C(Solv: methanol (67-56-1))
• 沸点：
  405.4±28.0 °C(Predicted)
• 密度：
  1.228±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2918990090
• 储存条件：
  存储条件：室温、密封、干燥

反应信息

• 作为反应物：
  描述：

  p-phenoxycinnamic acid 在 乙醇 、 sodium 、 三溴化磷 作用下， 生成 5-(4-苯氧基苯基)戊酸
  参考文献：
  名称：

  Thermal polymerization of p-allylphenyl phenyl ether

  摘要：

  DOI：

  10.1007/bf01176041
• 作为产物：
  描述：

  1-(氯甲基)-4-苯氧基苯 在 哌啶 、 吡啶 作用下， 生成 p-phenoxycinnamic acid
  参考文献：
  名称：

  MASSARANI; NARDI; MAURI, Farmaco, Edizione Scientifica, 1963, vol. 18, p. 582 - 594

  摘要：

  DOI：

文献信息

• [EN] AZAINDAZOLES AS BTK KINASE MODULATORS AND USE THEREOF<br/>[FR] AZAINDAZOLES COMME MODULATEURS DE LA KINASE BTK ET LEUR UTILISATION
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2011019780A1

  公开（公告）日：2011-02-17

  Compounds having the formula (I), and enantiomers, and diastereomers, pharmaceutically-acceptable salts, thereof, (I) are useful as kinase modulators, including Btk modulation, wherein A1, A2, A3, R4, are as defined herein.

  具有化学式(I)的化合物，以及其对映体、非对映异构体、药用可接受的盐，(I)可用作激酶调节剂，包括Btk调节，在此处定义了A1、A2、A3、R4。
• AMINO ACID DERIVATIVE
  申请人：Ookubo Tomohiro

  公开号：US20110172442A1

  公开（公告）日：2011-07-14

  The amino acid derivative of the present invention provides a novel compound that shows excellent analgesic action. The amino acid derivative of the present invention is a novel compound that shows excellent analgesic action to not only a model animal for nociceptive pains but also a model animal for neuropathic pains, so that the amino acid derivative is very useful as a drug for treating various pain diseases.

  本发明的氨基酸衍生物提供了一种显示出优异镇痛作用的新化合物。本发明的氨基酸衍生物是一种新化合物，不仅对于模拟伤害性疼痛的动物模型，而且对于模拟神经病理性疼痛的动物模型都显示出优异的镇痛作用，因此该氨基酸衍生物作为治疗各种疼痛疾病的药物非常有用。
• Studies of hypolipidemic agents. 1. Synthesis and hypolipidemic activities of alkoxycinnamic acid derivatives
  作者：Toshio Watanabe、Kimiaki Hayashi、Shigeki Yoshimatsu、Kazuo Sakai、Shigeyuki Takeyama、Kohki Takashima

  DOI：10.1021/jm00175a010

  日期：1980.1

  and their hypolipidemic activities were evaluated in a screening system with rats. Cinnamic acids, alpha-methylcinnamic acids, and their various esters with a higher p-alkoxy substituent were found to possess hypolipidemic activities higher than or comparable to that of clofibrate. The proper length (C12--C16) and the para position of the alkoxy substituent seem to be essential for activity. Chloroethyl

  合成了110多种烷氧基肉桂酸衍生物，并在大鼠筛选系统中评估了它们的降血脂活性。发现肉桂酸，α-甲基肉桂酸及其各种具有较高对烷氧基取代基的酯具有比氯贝贝特更高或相当的降血脂活性。适当的长度（C12-C16）和烷氧基取代基的对位似乎对活性至关重要。一些活性对烷氧基肉桂酸的氯乙基和甲基丙烯酰氧基乙基酯以及甘油单酯比相应的游离酸更具活性。
• Visible-Light-Mediated Oxidative Decarboxylative Coupling of Cinnamic Acid Derivatives with Tetrahydrofuran
  作者：Zheng Liu、Leifeng Wang、Dong Liu、Zhigang Wang

  DOI：10.1055/s-0035-1560661

  日期：——

  A visible-light-mediated protocol for direct oxidative decarboxylative coupling of various cinnamic acid derivatives with tetrahydrofuran was developed, leading to simple preparations of a range of vinyltetrahydrofurans under operationally mild and convenient conditions.

  开发了一种可见光介导的各种肉桂酸衍生物与四氢呋喃直接氧化脱羧偶联的方案，从而在操作温和方便的条件下简单地制备了一系列乙烯基四氢呋喃。
• Isoxazole compounds useful for the prophylaxis or treatment of nervous
  申请人：Sankyo Company, Limited

  公开号：US06005116A1

  公开（公告）日：1999-12-21

  Isoxazole compounds having the following general formula: ##STR1## wherein R.sup.1 represents an optionally substituted aryl group or aromatic heterocyclic group; R.sup.2 represents a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkenyl group, an alkoxy group, a cyano group, a carboxyl group, an alkanoyl group, an alkoxycarbonyl group or an optionally substituted carbamoyl group; R.sup.3 represents an optionally substituted amino group or a saturated heterocyclic group; X represents an oxygen atom or a sulfur atom; and n is an integer of from 2 to 6. These compounds have excellent monoamine oxidase inhibitory activity and are useful as a therapeutic agent or a preventive agent against nervous diseases such as depression.

  具有以下一般式的异噁唑化合物：##STR1## 其中 R.sup.1 代表可选取代的芳基或芳香杂环基；R.sup.2 代表氢原子、卤原子、可选取代的烷基、烯基、炔基、环烷基、环烯基、烷氧基、氰基、羧基、酰基、烷氧羰基或可选取代的氨基甲酰基；R.sup.3 代表可选取代的氨基或饱和杂环基；X 代表氧原子或硫原子；n 为2到6的整数。这些化合物具有出色的单胺氧化酶抑制活性，并可用作治疗剂或预防神经疾病如抑郁症的药物。