(1S,5S,7R)-(3-(4-methoxyphenyl)-6,8-dioxa-3-azabicyclo[3.2.1]oct-7-yl)methanol | 1155303-50-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (1S,5S,7R)-(3-(4-methoxyphenyl)-6,8-dioxa-3-azabicyclo[3.2.1]oct-7-yl)methanol
• CAS: 1155303-50-6
• 化学式: C₁₃H₁₇NO₄
• 分子量: 251.282
• InChiKey: AREZACGCWKULIU-XQQFMLRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.62
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  51.16
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  (1S,5S,7R)-7-benzyloxymethyl-3-(4-methoxyphenyl)-6,8-dioxa-3-azabicyclo[3.2.1]octane 在 palladium(II) hydroxide/carbon 、 环己烯 作用下， 以 乙醇 为溶剂， 以88%的产率得到(1S,5S,7R)-(3-(4-methoxyphenyl)-6,8-dioxa-3-azabicyclo[3.2.1]oct-7-yl)methanol
  参考文献：
  名称：

  N-Substituent effects on the diethylzinc addition to benzaldehyde catalysed by bicyclic 1,4-amino alcohols

  摘要：

  Chiral enantiopure bicyclic 1,4-aminoalcohols were synthesised by a new methodology that provided a common precursor, which was easily N-functionalised with a wide variety of substituents. The final compounds were used as chiral ligands in a model study of the enantioselective addition of diethyl zinc to benzaldehyde, aimed at understanding the influence of the N-substituent on both the rate and stereoselectivity of the reaction. This set of experiments also provided interesting insight into the non-catalysed addition that Occurred by employing commercially available Et(2)Zn solutions. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.01.021

文献信息

• N-Substituent effects on the diethylzinc addition to benzaldehyde catalysed by bicyclic 1,4-amino alcohols
  作者：Dina Scarpi、Ernesto G. Occhiato、Antonio Guarna

  DOI：10.1016/j.tetasy.2009.01.021

  日期：2009.2

  Chiral enantiopure bicyclic 1,4-aminoalcohols were synthesised by a new methodology that provided a common precursor, which was easily N-functionalised with a wide variety of substituents. The final compounds were used as chiral ligands in a model study of the enantioselective addition of diethyl zinc to benzaldehyde, aimed at understanding the influence of the N-substituent on both the rate and stereoselectivity of the reaction. This set of experiments also provided interesting insight into the non-catalysed addition that Occurred by employing commercially available Et(2)Zn solutions. (C) 2009 Elsevier Ltd. All rights reserved.