N-[(9H-fluoren-9-yl)methoxycarbonyl]glycine-N-methylamide | 1360114-01-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: N-[(9H-fluoren-9-yl)methoxycarbonyl]glycine-N-methylamide
• 英文别名: Fmoc-NHCH2C(O)NHMe；9H-fluoren-9-ylmethyl N-[2-(methylamino)-2-oxoethyl]carbamate
• CAS: 1360114-01-7
• 化学式: C₁₈H₁₈N₂O₃
• 分子量: 310.353
• InChiKey: IIUAWRXSNKJMEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(3-chloro-benzoyl)-2,6-dichloropyridine 、 N-[(9H-fluoren-9-yl)methoxycarbonyl]glycine-N-methylamide 在 palladium diacetate 、 caesium carbonate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 1,4-二氧六环 为溶剂， 反应 16.0h， 以30%的产率得到2-[9H-fluoren-9-ylmethoxycarbonyl]amino-N-(6-chloro-3-(3-chlorobenzoyl)pyridin-2-yl)-N-methyl-acetamide
  参考文献：
  名称：

  Novel access to 1,4-benzodiazepin-2-ones via the Buchwald reaction and application to the synthesis of novel heterocyclics

  摘要：

  A new two step strategy for the preparation of 1,4-benzodiazepin-2-ones has been developed starting from the 2-halogenobenzophenone under Buchwald conditions (Pd(OAc)(2), XantPhos, Cs2CO3, dioxane 100 degrees C). This strategy has been extended to two 2-halogeno-3-benzoyl-azines (pyridines, pyridazines). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.045
• 作为产物：
  描述：

  Fmoc-甘氨酸 、 甲胺 在 氯化亚砜 作用下， 以 甲苯 、 水 、 乙酸乙酯 为溶剂， 反应 0.5h， 以90%的产率得到N-[(9H-fluoren-9-yl)methoxycarbonyl]glycine-N-methylamide
  参考文献：
  名称：

  Novel access to 1,4-benzodiazepin-2-ones via the Buchwald reaction and application to the synthesis of novel heterocyclics

  摘要：

  A new two step strategy for the preparation of 1,4-benzodiazepin-2-ones has been developed starting from the 2-halogenobenzophenone under Buchwald conditions (Pd(OAc)(2), XantPhos, Cs2CO3, dioxane 100 degrees C). This strategy has been extended to two 2-halogeno-3-benzoyl-azines (pyridines, pyridazines). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.045

文献信息

• EP3008056B1
  申请人：——

  公开号：EP3008056B1

  公开（公告）日：2020-12-09
• GLP-1 RECEPTOR MODULATORS
  申请人：Celgene International II Sarl

  公开号：EP3230276B1

  公开（公告）日：2020-09-02
• Antibody Binding Affinity Ligands
  申请人：Johannsen Ib

  公开号：US20080311681A1

  公开（公告）日：2008-12-18

  The present application discloses a solid support material having covalently immobilized thereon an affinity ligand, said ligand comprising one or more hydrophobic functional group(s) and one or more cationic functional group(s) or one or more heteroaromatic functional group(s), wherein at least one hydrophobic functional group is separated from at least one cationic/heteroaromatic functional group by a through bond distance of from 5 Å to 20 Å, wherein said ligand has a molecular weight of from 120 Da to 5,000 Da. Typically, the affinity resin has a binding capacity larger than 5 mg monoclonal antibody per mL of affinity resin. A method for the isolation of biomolecules, such as proteins, in particular antibodies, such as monoclonal antibodies, or derivatives thereof, is also disclosed.
• Novel access to 1,4-benzodiazepin-2-ones via the Buchwald reaction and application to the synthesis of novel heterocyclics
  作者：Christophe Salomé、Martine Schmitt、Jean-Jacques Bourguignon

  DOI：10.1016/j.tetlet.2011.12.045

  日期：2012.2

  A new two step strategy for the preparation of 1,4-benzodiazepin-2-ones has been developed starting from the 2-halogenobenzophenone under Buchwald conditions (Pd(OAc)(2), XantPhos, Cs2CO3, dioxane 100 degrees C). This strategy has been extended to two 2-halogeno-3-benzoyl-azines (pyridines, pyridazines). (C) 2011 Elsevier Ltd. All rights reserved.