3-(1-Methyl-2-phenyl-ethylamino)-propionic acid | 128013-73-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(1-Methyl-2-phenyl-ethylamino)-propionic acid
• 英文别名: N-carboxyethyl-amphetamine；3-(1-phenylpropan-2-ylamino)propanoic acid
• CAS: 128013-73-0
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: SPZSYNHDKYXHDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 甲醇 作用下， 反应 4.0h， 生成 3-(1-Methyl-2-phenyl-ethylamino)-propionic acid
  参考文献：
  名称：

  A Synthesis ofN-Substituted β-Alanines: Michael Addition of Amines to Trimethylsilyl Acrylate

  摘要：

  对甲基硅烯丙烯酸酯 (1) 进行的迈克尔加成反应中，原级和次级胺 (2) 分别得到良好产率的 β-(烷基氨基) 和 β-(二烷基氨基) -丙酸 (4)。

  DOI：

  10.1055/s-1989-27440

文献信息

• Reagents, methods and kits for an amphetamine-class fluorescence
  申请人：Abbott Laboratories

  公开号：US05248791A1

  公开（公告）日：1993-09-28

  A fluorescence polarization immunoassay (FPIA) for detecting the presence of one or more amphetamine-class analytes in a test sample is provided. The immunoassay uses competition between the analyte and a fluorescently labeled tracer for the binding site on an antibody specific for phenethylamine derivatives. The concentration of amphetamine-class analyte in the sample determines the amount of tracer that binds to the antibody. The amount of tracer/antibody complex formed can be quantitatively measured and is inversely proportional to the quantity of analyte in the test sample. The invention relates to tracers, to immunogens used to elicit antibodies for use as assay reagents, and to assay kits incorporating these tracers and assay reagents.

  本发明提供了一种荧光偏振免疫测定法（FPIA），用于检测测试样品中一种或多种苯丙胺类分析物的存在。该免疫测定法利用分析物与荧光标记示踪剂在特异于苯乙胺衍生物的抗体结合位点上的竞争。样品中苯丙胺类分析物的浓度决定了结合到抗体的示踪剂的数量。所形成的示踪剂/抗体复合物的数量可以定量测量，并且与测试样品中分析物的数量成反比。本发明涉及示踪剂，用于引发用作测定试剂的抗体的免疫原，以及包含这些示踪剂和测定试剂的测定试剂盒。
• Reagents for an amphetamine-class fluorescence polarization immunoassay
  申请人：Abbott Laboratories

  公开号：US05101015A1

  公开（公告）日：1992-03-31

  A fluorescence polarization immunoassay (FPIA) for detecting the presence of one or more amphetamine-class analytes in a test sample is provided. The immunoassay uses competition between the analyte and a fluorescently labeled tracer for the binding site on an antibody specific for phenethylamine derivatives. The concentration of amphetamine-class analyte in the sample determines the amount of tracer that binds to the antibody. The amount of tracer/antibody complex formed can be quantitatively measured and is inversely proportional to the quantity of analyte in the test sample. The invention relates to tracers, to immunogens used to elicit antibodies for use as assay reagents, and to assay kits incorporating these tracers and assay reagents.

  提供了一种用于检测测试样品中一个或多个苯丙胺类分析物存在的荧光偏振免疫测定（FPIA）。该免疫测定利用分析物和荧光标记的示踪剂之间在特异性对苯乙胺衍生物的抗体的结合位点上的竞争。样品中苯丙胺类分析物的浓度确定了结合到抗体的示踪剂的量。形成的示踪剂/抗体复合物的量可以定量测量，并且与测试样品中分析物的数量成反比。该发明涉及示踪剂，用于诱导抗体用作测定试剂的免疫原，以及包含这些示踪剂和测定试剂的测定试剂盒。
• KWIATKOWSKI, STEFAN;JEGANATHAN, AZHWARSAMY;TOBIN, THOMAS;WATT, DAVID S., SYNTHESIS,(1989) N2, C. 946-949
  作者：KWIATKOWSKI, STEFAN、JEGANATHAN, AZHWARSAMY、TOBIN, THOMAS、WATT, DAVID S.

  DOI：——

  日期：——
• Reagents, methods and kits for an amphetamine-class fluorescence polarization immunoassay
  申请人：ABBOTT LABORATORIES

  公开号：EP0399184B1

  公开（公告）日：1995-09-13
• US5101015A
  申请人：——

  公开号：US5101015A

  公开（公告）日：1992-03-31