biscinamaldehyde-o-phenylenediamine | 918450-64-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: biscinamaldehyde-o-phenylenediamine
• 英文别名: (E)-3-phenyl-N-[2-[[(E)-3-phenylprop-2-enylidene]amino]phenyl]prop-2-en-1-imine
• CAS: 918450-64-3
• 化学式: C₂₄H₂₀N₂
• 分子量: 336.436
• InChiKey: SDUCXYLVZULSEN-UXFYGQBOSA-N

物化性质

• 沸点：
  549.9±50.0 °C(Predicted)
• 密度：
  0.98±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  biscinamaldehyde-o-phenylenediamine 在 对甲苯磺酸 作用下， 以 neat (no solvent) 为溶剂， 以88%的产率得到1-肉桂基-2-(E)-苯乙烯基-1H-苯并[d]咪唑
  参考文献：
  名称：

  Facile Synthesis of 1,2-Disubstituted Benzimidazoles Usingp-Toluenesulfonic Acid through Grinding Method

  摘要：

  An efficient synthetic method for the highly selective synthesis of pharmacologically active 1,2-disubstituted benzimidazole derivatives fromo-phenylenediamine and various aromatic aldehydes catalyzed byp-toluenesulfonic acid through grinding under solvent-free condition is described. The reaction requires the catalyst only during the conversion of intermediateN,N '-dibenzylidene-o-phenylenediamine into the desired product. The products were obtained within a short time with good yields by using only a mortar and pestle, which makes the proposed method convenient and cost-effective.

  DOI：

  10.1134/s1070428020090201
• 作为产物：
  描述：

  反式肉桂醛 、 邻苯二胺 以 neat (no solvent) 为溶剂， 反应 0.17h， 生成 biscinamaldehyde-o-phenylenediamine
  参考文献：
  名称：

  Facile Synthesis of 1,2-Disubstituted Benzimidazoles Usingp-Toluenesulfonic Acid through Grinding Method

  摘要：

  An efficient synthetic method for the highly selective synthesis of pharmacologically active 1,2-disubstituted benzimidazole derivatives fromo-phenylenediamine and various aromatic aldehydes catalyzed byp-toluenesulfonic acid through grinding under solvent-free condition is described. The reaction requires the catalyst only during the conversion of intermediateN,N '-dibenzylidene-o-phenylenediamine into the desired product. The products were obtained within a short time with good yields by using only a mortar and pestle, which makes the proposed method convenient and cost-effective.

  DOI：

  10.1134/s1070428020090201

文献信息

• Srivastava; Srivastava; Sharma, Journal of the Indian Chemical Society, 1990, vol. 67, # 4, p. 310 - 312
  作者：Srivastava、Srivastava、Sharma

  DOI：——

  日期：——
• Facile Synthesis of 1,2-Disubstituted Benzimidazoles Usingp-Toluenesulfonic Acid through Grinding Method
  作者：C. Kathing、N. G. Singh、J. World Star Rani、R. Nongrum、R. Nongkhlaw

  DOI：10.1134/s1070428020090201

  日期：2020.9

  An efficient synthetic method for the highly selective synthesis of pharmacologically active 1,2-disubstituted benzimidazole derivatives fromo-phenylenediamine and various aromatic aldehydes catalyzed byp-toluenesulfonic acid through grinding under solvent-free condition is described. The reaction requires the catalyst only during the conversion of intermediateN,N '-dibenzylidene-o-phenylenediamine into the desired product. The products were obtained within a short time with good yields by using only a mortar and pestle, which makes the proposed method convenient and cost-effective.