2-(3,4-dimethylphenyl)-1,1,1,3,3,3-hexafluoro-2-propanol | 2379-17-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3,4-dimethylphenyl)-1,1,1,3,3,3-hexafluoro-2-propanol
• 英文别名: 3,4-Dimethyl-1-<2-hydroxy-hexafluor-2-propyl>-benzol；3,4-Dimethyl-1-(2-hydroxy-hexafluor-2-propyl)-benzol；2-(3,4-Dimethylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol
• CAS: 2379-17-1
• 化学式: C₁₁H₁₀F₆O
• 分子量: 272.19
• InChiKey: DDLQAOJQQSJPIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  邻二甲苯 、 2-(3,4-dimethylphenyl)-1,1,1,3,3,3-hexafluoro-2-propanol 在 氢氟酸 作用下， 生成 2,2-双(3,4-二甲苯基)六氟丙烷
  参考文献：
  名称：

  Investigation of the HF-catalyzed condensation reaction to diarylhexafluoropropanes

  摘要：

  DOI：

  10.1016/s0022-1139(00)83602-7
• 作为产物：
  描述：

  邻二甲苯 、 六氟丙酮 在 氢氟酸 作用下， 100.0 ℃ 、374.93 kPa 条件下， 反应 17.0h， 以40 g的产率得到2-(3,4-dimethylphenyl)-1,1,1,3,3,3-hexafluoro-2-propanol
  参考文献：
  名称：

  一种2-（3,4-二甲苯基）-1,1,1,3,3,3-六氟-2-丙醇的制备方法

  摘要：

  本发明提供了一种制备2-(3,4-二甲苯基)-1,1,1,3,3,3-六氟-2-丙醇的方法，使邻二甲苯与六氟丙酮一水合物在氟化氢的作用下经液相反应得到。本发明提供的方法原料毒性低、反应压力低、易操作、反应选择性和收率高、适合工业化生产。制备的2-(3,4-二甲苯基)-1,1,1,3,3,3-六氟-2-丙醇适合用作含氟医药中间体。

  公开号：

  CN106699509A

文献信息

• NOVEL FLUORINE-CONTAINING DICARBOXYLIC ACIDS AND THEIR NOVEL POLYMER COMPOUNDS
  申请人：Narizuka Satoru

  公开号：US20090030173A1

  公开（公告）日：2009-01-29

  Disclosed is a fluorine-containing dicarboxylic acid represented by formula (1), wherein n represents an integer of 1-4, and the two carboxylic groups are not adjacent to each other on the aromatic ring. It is possible to obtain a linear polymer compound by reacting the fluorine-containing dicarboxylic acid with a comonomer (e.g., diaminodiol). By thermal cyclization, this linear polymer compound can be converted into another polymer compound having superior characteristics.

  本发明公开了一种含氟的二羧酸，其化学式表示为（1），其中n表示1-4的整数，两个羧基不相邻于芳环上。通过将含氟二羧酸与共聚单体（例如，二氨基二醇）反应，可以获得线性聚合物化合物。通过热环化，这种线性聚合物化合物可以转化为具有优异特性的另一种聚合物化合物。
• .alpha.-fluoroacrylic acid esters and polymers thereof
  申请人：Hoechst Aktiengesellschaft

  公开号：US05198925A1

  公开（公告）日：1993-03-30

  Esters of .alpha.-fluoroacrylic acid are accessible by hydrolysis of an .alpha.-hydroxymethyl-.alpha.-fluoromalonic acid ester, decarboxylation and dehydration of the hydrolysis product and subsequent esterification of the resulting .alpha.-fluoroacrylic acid with an alcohol. The esters are polymerizable and are suitable for use as a starting material for preparing fluoropolymers which in turn are usable as materials for manufacturing transparent articles. The polymers are high-molecular and non-crystalline and have softening temperatures of above 100.degree. C.

  .alpha.-氟丙烯酸酯可以通过以下步骤制备：首先，水解.alpha.-羟甲基-.alpha.-氟丙二酸酯，然后脱羧和脱水处理水解产物，最后将得到的.alpha.-氟丙烯酸与醇酯化。这些酯类可以聚合，并适用于用作制备透明物品的材料的起始物质。聚合物是高分子量和非晶态的，软化温度在100℃以上。
• Fluoro-anhydride curing agents and precursors thereof for fluorinated
  申请人：The United States of America as represented by the Secretary of the Navy

  公开号：US04045408A1

  公开（公告）日：1977-08-30

  Fluoro-anhydride curing agents for fluorinated epoxy resins, especially for highly fluorinated epoxy resins selected from the class consisting of hydroxyperfluoroalkyl phthalic anhydride, hydroxyperfluoroalkyl pyromellitic dianhydride, and mixtures thereof; a fluoro-anhydride curing agent for fluorinated epoxy resins that is the toluene-soluble mixture prepared by heating a hydroxyperfluoroalkyl benzenepentacarboxylic acid at about 240.degree. C; precursors for all of the curing agents; and the epoxy resins prepared therefrom.

  氟代环氧树脂用的氟代酸酐固化剂，特别适用于高度氟化的氟代环氧树脂，所选的氟代酸酐固化剂来自于羟基全氟烷基邻苯二甲酸酐、羟基全氟烷基苯并二酐和它们的混合物；一种氟代环氧树脂用的氟代酸酐固化剂，是通过将羟基全氟烷基苯并五酸加热至约240℃制备的甲苯可溶混合物；所有固化剂的前体；以及由此制备的环氧树脂。
• Fluorine-Containing Dicarboxylic Acids and Their Novel Polymer Compounds
  申请人：NARIZUKA Satoru

  公开号：US20110282026A1

  公开（公告）日：2011-11-17

  A fluorine-containing dicarboxylic acid represented by formula (1), wherein n represents an integer of 1-4, and the two carboxylic groups are not adjacent to each other on the aromatic ring. It is possible to obtain a linear polymer compound by reacting the fluorine-containing dicarboxylic acid with a comonomer (e.g., diaminodiol). By thermal cyclization, this linear polymer compound can be converted into another polymer compound having superior characteristics.

  公式(1)表示的是含氟二羧酸，其中n代表1-4的整数，且两个羧基不相邻于芳香环上。通过将含氟二羧酸与共聚物（例如二氨基二醇）反应，可以得到线性聚合物化合物。通过热环化，这种线性聚合物化合物可以转化为具有卓越特性的另一种聚合物化合物。
• Fluorinated Dicarboxylic Acid Derivative and Polymer Obtained Therefrom
  申请人：Isono Yoshimi

  公开号：US20110301305A1

  公开（公告）日：2011-12-08

  According to the present invention, a polymer is obtained by polycondensation of a fluorinated dicarboxylic acid derivative of the general formula (M-1) or an acid anhydride of the fluorinated dicarboxylic acid with a polyfunctional compound having two to four reactive groups corresponding in reactivity to carbonyl moieties of the fluorinated dicarboxylic acid derivative or acid anhydride. [Chem. 134] AOCF 2 C-Q-CF 2 COA′  (M-1) In the above formula, Q represents a divalent organic group having a substituted or unsubstituted aromatic ring; and A and A′ each independently represent an organic group. This polymer exhibits a sufficiently low dielectric constant for use as a semiconductor protection film and has the capability of forming a film at a relatively low temperature of 250° C. or lower.

  根据本发明，通过将通式(M-1)的含氟二羧酸衍生物或含氟二羧酸酸酐与具有与含氟二羧酸衍生物或酸酐的羰基部分相对应的两到四个反应性基团的多官能化合物进行聚合缩合反应，可以得到一种聚合物。[Chem. 134]AOCF2C-Q-CF2COA′  (M-1)在上述公式中，Q代表具有取代或未取代芳香环的二价有机基团; A和A'各自独立地表示有机基团。该聚合物表现出足够低的介电常数，可用作半导体保护膜，并具有在相对较低的温度下（250℃或更低）形成膜的能力。