作者:Zheng-Min Yang、Long Lu
DOI:10.1002/jlcr.1749
日期:——
ZJ0273 (propyl 4-(2-(4,6-dimethoxypyrimidin-2-yloxy)benzylamino)benzoate), ZJ0702 (isopropyl 4-(2-(4,6-dimethoxypyrimidin-2-yloxy)benzylamino)benzoate), ZJ0777 (2-bromo-N-(2-(4,6-dimethoxypyrimidin-2-yloxy)benzyl)aniline), and SIOC0163 (5-bromo-N-(2-(4,6-dimethoxypyrimidin-2-yloxy)benzyl)pyridin-2-amine) are active ingredients in oilseed rape herbicides. The middle aromatic ring-deuterated form of ZJ0273 was synthesized from (2H6)phenol and have been successfully used as tracer in its metabolism and degradation study. The methoxyl-deuterated forms of four ingredients were synthesized from (2H4)methanol, respectively, and they could be used as internal standards in quantitation of herbicide residue in rapeseed and its downstream foodstuff by using HPLC-MS/MS. Copyright © 2010 John Wiley & Sons, Ltd.
ZJ0273(丙基4-(2-(4,6-二甲氧基嘧啶-2-氧基)苯甲胺)苯甲酸酯)、ZJ0702(异丙基4-(2-(4,6-二甲氧基嘧啶-2-氧基)苯甲胺)苯甲酸酯)、ZJ0777(2-溴-N-(2-(4,6-二甲氧基嘧啶-2-氧基)苯基)氨基苯)、和SIOC0163(5-溴-N-(2-(4,6-二甲氧基嘧啶-2-氧基)苯基)吡啶-2-胺)是油菜 herbicides 的活性成分。ZJ0273 的中间芳香环重氘化形式是通过 (2H6) 苯酚合成的,并已成功用于其代谢和降解研究中的示踪剂。四种成分的甲氧基重氘化形式分别是通过 (2H4) 甲醇合成的,并可以作为内标在HPLC-MS/MS中用于油菜及其下游食品中农药残留的定量分析。版权所有 © 2010 John Wiley & Sons, Ltd.