p-methoxyphenyl dichlorophosphite | 135263-41-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: p-methoxyphenyl dichlorophosphite
• 英文别名: p-methoxyphenyl phosphorodichloridite；dichloro-(4-methoxy-phenoxy)-phosphine；Phosphorigsaeure-(4-methoxy-phenylester)-dichlorid；Dichlor-(4-methoxy-phenoxy)-phosphin；Dichlorophosphorigsaeure-(4-methoxy-phenylester)；(4-Methoxy-phenyl)-dichlorophosphit；Dichloro-(4-methoxyphenoxy)phosphane
• CAS: 135263-41-1
• 化学式: C₇H₇Cl₂O₂P
• 分子量: 225.011
• InChiKey: MZKOSHFMVHTKLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  p-methoxyphenyl dichlorophosphite 在 三乙胺 作用下， 以 正己烷 为溶剂， 反应 336.0h， 生成 三(4-甲氧基苯基)亚磷酸酯
  参考文献：
  名称：

  Synthesis of Non-Symmetric Functionalized Polyfluoroalkyl Phosphites

  摘要：

  Two ways for the synthesis of new representatives of non-symmetric organic phosphites with polyfluoroalkyl substituents were developed based on organic dichlorophosphites. The reaction of polyfluoroalkyl dichlorophosphites with allyl alcohol, proceeding at a temperature of -10-22 degrees C (2 h) in the presence of triethylamine, gave diallyl polyfluoroalkyl phosphites in a yield of 75-77%. Under similar conditions (-30-22 degrees C, 2-4 h, Et3N), alkyl (or aryl) dichlorophosphites reacted with polyfluoroalkanols to form alkyl (or aryl) bis(polyfluoroalkyl) phosphites (yield 56-67%). Unlike diallylpolyfluoroalkyl- and alkylbis(polyfluoroalkyl) phosphites, arylbis(polyfluoroalkyl) phosphites are symmetrized under storage conditions (room temperature, inert atmosphere), forming the corresponding triaryl- and tris(polyfluoroalkyl) phosphites.

  DOI：

  10.1134/s1070363220050138
• 作为产物：
  描述：

  4-甲氧基苯酚 在 三氯化磷 作用下， 生成 p-methoxyphenyl dichlorophosphite
  参考文献：
  名称：

  Anschuetz et al., Justus Liebigs Annalen der Chemie, 1936, vol. 525, p. 297,301 Anm. 1, 306, 308, 309

  摘要：

  DOI：

文献信息

• Enantioselective Rhodium-Catalyzed Addition of Arylboronic Acids to Aldehydes Using Chiral Spiro Monophosphite Ligands
  作者：Hai-Feng Duan、Jian-Hua Xie、Wen-Jian Shi、Qi Zhang、Qi-Lin Zhou

  DOI：10.1021/ol060360c

  日期：2006.3.1

  [reaction: see text] Highly efficient rhodium-catalyzed asymmetric addition of arylboronic acids to aldehydes has been realized by using chiral spiro monophosphite ligands, affording diarylmethanols in excellent yields and good enantiomeric excesses.

  [反应：见正文]通过使用手性螺一亚磷酸酯配体实现了铑催化芳基硼酸向醛的高效不对称加成，从而以优异的收率和良好的对映体过量提供了二芳基甲醇。
• One-Pot Synthesis of Aryl Phosphoramidate Derivatives of AZT/d4T as Anti-HIV Prodrugs
  作者：Hua Fu、Peng Jiang、Xin Guo、Yuyang Jiang、Yufen Zhao

  DOI：10.1055/s-2005-917085

  日期：——

  Arbuzov reaction of aryl phosphorodichloridite with mixture of one equivalent of AZT or d4T and one equivalent of tert-butyl alcohol led to the corresponding AZT/d4T aryl H-phosphonate diesters, and the following reactionof the H-phosphonate diesters with amino acid methyl esters in the presence of N-chloro-succinimide (NCS) produced membrane-soluble anti-HIV prodrugs AZT/d4T aryl phosphoramidate derivatives

  芳基二氯化磷与一当量 AZT 或 d4T 和一当量叔丁醇的混合物的 Arbuzov 反应产生相应的 AZT/d4T 芳基 H-膦酸二酯，H-膦酸二酯与氨基酸甲酯的以下反应N-氯-琥珀酰亚胺 (NCS) 的存在以良好的产率产生了膜溶性抗 HIV 前药 AZT/d4T 芳基氨基磷酸酯衍生物。
• Kazantseva, M. V.; Timokhin, B. V.; Donskikh, V. I., Journal of general chemistry of the USSR, 1991, vol. 61, # 4.2., p. 932
  作者：Kazantseva, M. V.、Timokhin, B. V.、Donskikh, V. I.

  DOI：——

  日期：——
• KAZANTSEVA, M. V.;TIMOXIN, B. V.;DONSKIX, V. I., ZH. OBSHCH. XIMII, 61,(1991) N, S. 53-54
  作者：KAZANTSEVA, M. V.、TIMOXIN, B. V.、DONSKIX, V. I.

  DOI：——

  日期：——
• Synthesis of Non-Symmetric Functionalized Polyfluoroalkyl Phosphites
  作者：N. K. Gusarova、S. F. Malysheva、N. A. Belogorlova、S. I. Verkhoturova、L. A. Oparina、S. N. Arbuzova、N. A. Chernysheva、A. M. Nalibayeva、G. K. Bishimbayeva、S. V. Yas’ko、B. A. Trofimov

  DOI：10.1134/s1070363220050138

  日期：2020.5

  Two ways for the synthesis of new representatives of non-symmetric organic phosphites with polyfluoroalkyl substituents were developed based on organic dichlorophosphites. The reaction of polyfluoroalkyl dichlorophosphites with allyl alcohol, proceeding at a temperature of -10-22 degrees C (2 h) in the presence of triethylamine, gave diallyl polyfluoroalkyl phosphites in a yield of 75-77%. Under similar conditions (-30-22 degrees C, 2-4 h, Et3N), alkyl (or aryl) dichlorophosphites reacted with polyfluoroalkanols to form alkyl (or aryl) bis(polyfluoroalkyl) phosphites (yield 56-67%). Unlike diallylpolyfluoroalkyl- and alkylbis(polyfluoroalkyl) phosphites, arylbis(polyfluoroalkyl) phosphites are symmetrized under storage conditions (room temperature, inert atmosphere), forming the corresponding triaryl- and tris(polyfluoroalkyl) phosphites.