4-methyl-2-oxazolidone | 16112-59-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 4-methyl-2-oxazolidone
• 英文别名: 4-methyl-2-oxazolidinone；4-methyloxazolidin-2-one；4-methyl-1,3-oxazolidin-2-one
• CAS: 16112-59-7
• 化学式: C₄H₇NO₂
• 分子量: 101.105
• InChiKey: VAJFEOKPKHIPEN-UHFFFAOYSA-N

物化性质

• 熔点：
  56-57 °C
• 沸点：
  109-111 °C(Press: 2 Torr)
• 密度：
  1.095±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  4-methyl-2-oxazolidone 在 六甲基二硅氮烷 作用下， 生成 N-trimethylsilyl-4R-methyloxazolidin-2-one
  参考文献：
  名称：

  Substituted benzo[b]pyrans, processes for their preparation, their use

  摘要：

  公式I的Benzo[b]pyran衍生物##STR1##，其中E--D等于CH--CHOH或C.dbd.CH；X等于氧或硫；Y等于氧、硫、SO、SO.sub.2或NR.sup.9；R.sup.1等于CN、NO.sub.2、Hal、烷氧羰基、SO.sub.1-2-烷基或SO.sub.1-2-芳基；R.sup.2等于H、OH、烷氧基、烷基、Hal、NR.sup.10 R.sup.11；R.sup.3 /R.sup.4等于烷基；R.sup.5 /R.sup.6等于烷基、(CH.sub.2).sub.1-6 COO-烷基、(CH.sub.2).sub.1-6 CONR.sup.10 R.sup.11、(CH.sub.2).sub.0-6 COOH、(CH.sub.2).sub.1-6 CO-烷基、CO.sub.2-烷基、烷基巯基烷基、烷基磺酰基、羟基烷基、巯基烷基、氨基烷基、N-(二)烷基氨基烷基或(CH.sub.2).sub.f Ar，其中f等于零至3；R.sup.7 /R.sup.8等于氢、烷基或苯基，m等于零至2，是杰出的降压药和解痉药。描述了制备过程和用途。

  公开号：

  US05130310A1
• 作为产物：
  描述：

  2-甲基氮丙啶 在 二氧化碳 、 碘 作用下， 以 氯仿 为溶剂， 生成 4-methyl-2-oxazolidone
  参考文献：
  名称：

  Process for preparing 2-oxazolidone and its derivatives

  摘要：

  通过将二氧化碳与环氧丙胺化合物反应制备2-噁唑烷酮及其衍生物的过程，最好在路易斯酸存在下作为催化剂。

  公开号：

  US04209628A1

文献信息

• [EN] INDAZOLOPYRIMIDINONES AS FIBRINOLYSIS INHIBITORS<br/>[FR] INDAZOLOPYRIMIDINONES COMME INHIBITEURS DE LA FIBRINOLYSE
  申请人：BAYER PHARMA AG

  公开号：WO2016173948A1

  公开（公告）日：2016-11-03

  The present application relates to novel substituted indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

  本申请涉及新型取代吲唑吡咯嘧啶酮，其制备方法，以及用于治疗和/或预防疾病的化合物，特别是用于治疗和/或预防患有或不患有基础遗传或获得性止血障碍的患者急性和复发性出血的方法，其中出血与从重经期出血、产后出血、出血性休克、创伤、手术、移植、中风、肝病、遗传性血管性水肿、鼻血、以及血液积聚后的滑膜炎和软骨损伤等一组疾病或医疗干预有关。
• ISOQUINOLINES AS INHIBITORS OF HPK1
  申请人：Genentech, Inc.

  公开号：US20180282282A1

  公开（公告）日：2018-10-04

  Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

  描述了异喹啉化合物及其作为HPK1（造血激酶1）抑制剂的用途。这些化合物在治疗依赖于HPK1的疾病和增强免疫应答方面非常有用。还描述了抑制HPK1的方法、治疗依赖于HPK1的疾病的方法、增强免疫应答的方法，以及制备异喹啉化合物的方法。
• Regioselectivity and selective enhancement of carbon dioxide fixation of 2-substituted aziridines to 2-oxazolidinones under supercritical conditions
  作者：Hajime Kawanami、Yutaka Ikushima

  DOI：10.1016/s0040-4039(02)00676-7

  日期：2002.5

  Under supercritical CO2 conditions, regioselectivity in the carbon dioxide fixation of 2-substituted aziridines to 2-oxazolidinones was observed with good yields around 75%. Furthermore, when propylene imine was used in the place of aziridine, the yield was significantly and selectively increased around the critical pressure, and the maximum yield was obtained at 11.8 MPa. The turnover frequency (TOF)

  在超临界CO 2条件下，观察到2-取代的氮丙啶在二氧化碳中固定为2-恶唑烷酮的区域选择性，产率约为75％。此外，当使用丙烯亚胺代替氮丙啶时，产率在临界压力附近显着且选择性地增加，并且在11.8MPa下获得最大产率。在此压力下的周转频率（TOF）是迄今报道的在6.9 MPa的乙醇中获得的TOF的2.1倍。
• A sustainable protocol for the facile synthesis of zinc-glutamate MOF: an efficient catalyst for room temperature CO₂fixation reactions under wet conditions
  作者：Amal Cherian Kathalikkattil、Roshith Roshan、Jose Tharun、Robin Babu、Gyeong-Seon Jeong、Dong-Woo Kim、Sung June Cho、Dae-Won Park

  DOI：10.1039/c5cc07781h

  日期：——

  A water stable zinc-MOF (ZnGlu) catalyst was facilely prepared from the proteinogenic amino acid, L-glutamic acid at room temperature in aqueous medium. CO2 fixations were promoted by the ZnGlu catalyst's...

  在室温下，在水性介质中，由蛋白氨基酸L-谷氨酸容易地制备出水稳定的锌MOF（ZnGlu）催化剂。ZnGlu催化剂的催化作用促进了CO 2的固定。
• The solvent-free and catalyst-free conversion of an aziridine to an oxazolidinone using only carbon dioxide
  作者：Chau Phung、Rani M. Ulrich、Mostafa Ibrahim、Nathaniel T. G. Tighe、Deborah L. Lieberman、Allan R. Pinhas

  DOI：10.1039/c1gc15850c

  日期：——

  It has been found for the first time at room temperature that the reaction of an unactivated 2-alkyl or 2-aryl aziridine with carbon dioxide to generate the corresponding oxazolidinone does not need any form of catalysis or solvent to proceed in high yield, especially when using high speed ball milling.

  首次在室温下发现，未活化的2-烷基或2-芳基氮杂环丙烷与二氧化碳反应生成相应的恶唑烷酮，无需任何形式的催化剂或溶剂，即可高产率进行，尤其是在使用高速球磨的情况下。

表征谱图