ethyl 3,5-dichloro-2-hydroxybenzoate | 68276-69-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 3,5-dichloro-2-hydroxybenzoate
• 英文别名: 3,5-dichloro-2-hydroxy-benzoic acid ethyl ester；3,5-Dichlor-2-hydroxy-benzoesaeure-aethylester；3.5-Dichlor-salicylsaeure-aethylester
• CAS: 68276-69-7
• 化学式: C₉H₈Cl₂O₃
• 分子量: 235.067
• InChiKey: SUGDTRDGSCWRGF-UHFFFAOYSA-N

物化性质

• 沸点：
  295.4±35.0 °C(Predicted)
• 密度：
  1.414±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl 3,5-dichloro-2-hydroxybenzoate 在 氢氧化钾 、 potassium carbonate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 96.0h， 生成 3,5-dichloro-2-ethoxybenzoic acid
  参考文献：
  名称：

  Banks, William R.; Moerlein, Stephen M.; Parkinson, David, Medicinal Chemistry Research, 1995, vol. 5, # 2/3, p. 150 - 173

  摘要：

  DOI：
• 作为产物：
  描述：

  水杨酸乙酯 在 氯 作用下， 生成 ethyl 3,5-dichloro-2-hydroxybenzoate
  参考文献：
  名称：

  Adrenocortical Dysfunction Following Etomidate Induction in Emergency Department Patients

  摘要：

  Abstract. Objective: To assess adrenocortical function following intravenous etomidate use in emergency department (ED) patients requiring intubation. Methods: This was a prospective, randomized, controlled trial of consecutive patients presenting to the ED requiring intubation. Patients were randomized to receive a single bolus induction dose of either 0.05‐0.1 mg/kg midazolam (control group) or 0.3 mg/kg etomidate (etomidate group) during a standardized rapid‐sequence intubation (RSI) with succinylcholine. The primary outcome variable was adrenocortical function at 4, 12, and 24 hours post‐induction as assessed by measured serum cortisol response to exogenous cosyntropin (cosyntropin stimulation test, CST). Fisher's exact test was used to compare CST results between groups. Results: Thirty‐one patients were enrolled: 8 control, 10 etomidate, and 13 excluded from analysis for either incomplete data or steroid use during the study period. The 4‐hour CST results were significantly different between study groups, with a normal response in 100% of control patients vs 30% of etomidate patients (p = 0.004). The 12‐ and 24‐hour CSTs did not differ significantly between groups: normal CST in 100% of control patients at 12 and 24 hours vs 100% and 90% among etomidate patients at 12 and 24 hours, respectively (p = 1.0 at 12 and 24 hours). Measured cortisol levels of patients with abnormal CSTs remained within normal laboratory reference ranges. Conclusion: Use of etomidate in ED patients requiring RSI results in adrenocortical dysfunction. However, cortisol levels remain within normal laboratory levels during this period of dysfunction. Adrenocortical dysfunction appears to resolve within 12 hours of a single bolus dose of 0.3 mg/kg etomidate.

  DOI：

  10.1111/j.1553-2712.2001.tb00537.x

文献信息

• O-ethyl-S-N-propyl-O-(substituted pheny)-phosphorothiolates
  申请人：Bayer Aktiengesellschaft

  公开号：US03954919A1

  公开（公告）日：1976-05-04

  O-ethyl-S-n-propyl-O-(substituted phenyl)-phosphorothiolates of the general formula ##SPC1## Wherein X is halogen, lower alkyl, nitro, cyano, lower alkylmercapto, lower alkylsulfinyl, lower alkoxycarbonyl or lower alkyl carbonyl, and m is 1, 2 or 3, Which possess insecticidal, acaricidal and nematocidal properties.

  通式为##SPC1##的O-乙基-S-正丙基-O-(取代苯基)-磷硫酸酯，其中X为卤素、低烷基、硝基、氰基、低烷基硫醇基、低烷基砜基、低烷氧羰基或低烷基羰基，m为1、2或3，具有杀虫、杀螨和杀线虫的特性。
• Anschuetz,R.; Mehring, Justus Liebigs Annalen der Chemie, 1906, vol. 346, p. 302
  作者：Anschuetz,R.、Mehring

  DOI：——

  日期：——
• Smith, Chemische Berichte, 1878, vol. 11, p. 1225
  作者：Smith

  DOI：——

  日期：——
• Martini, Gazzetta Chimica Italiana, 1899, vol. 29 II, p. 60
  作者：Martini

  DOI：——

  日期：——
• Ionescu et al., Academia Republicii Populare Romine, Filiala Cluj, Studii si Cercetari de Chimie, 1957, vol. 8, p. 351,358
  作者：Ionescu et al.

  DOI：——

  日期：——