hexadecyl protocatechuate | 31086-05-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: hexadecyl protocatechuate
• 英文别名: Hexadecyl 3,4-dihydroxybenzoate
• CAS: 31086-05-2
• 化学式: C₂₃H₃₈O₄
• 分子量: 378.552
• InChiKey: QRQSPUKAWQSJHF-UHFFFAOYSA-N

物化性质

• 沸点：
  517.5±30.0 °C(Predicted)
• 密度：
  1.018±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  27
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  原儿茶酸 、 1-十六烷醇 在 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 为溶剂， 反应 48.0h， 生成 hexadecyl protocatechuate
  参考文献：
  名称：

  抑制HIV-1蛋白酶二聚的烷基羟基苯甲酸衍生物。

  摘要：

  没食子酸及其衍生物作为抗癌剂，抗微生物剂和抗病毒剂的治疗潜力是众所周知的。我们已经研究了天然没食子酸和新合成的没食子酸烷基酯以及相关的原儿茶酸烷基酯抑制HIV-1蛋白酶的机制，以比较芳香环取代对抑制的影响。我们使用Zhang-Poorman的动力学分析和荧光探针结合来证明几种没食子酸和蛋白儿茶酸烷基酯通过阻止这种专性同二聚天冬氨酸蛋白酶的二聚作用而不是靶向活性位点来抑制HIV-1蛋白酶。没食子酸酯中的三羟基取代的苯甲酸部分比原儿茶酸酯中的二取代的苯甲酸部分更有利。在这两个系列中，抑制的类型 其机理和抑制效率极大地取决于烷基链的长度：对长度小于8个碳原子的烷基链没有抑制作用。分子动力学模拟证实了动力学数据，并提出没食子酸酯插在两个N和C单体末端之间。他们完成了β-折叠并破坏了二聚酶。最好的没食子酸酯（14个碳原子，K（id）为320 nM）也抑制了多突变蛋白酶MDR-HM。这些结果将有助于合

  DOI：

  10.2174/092986712803251557

文献信息

• Thermochromic solid having reversibly invisible/visible construction enclosed therein
  申请人：THE PILOT INK CO., LTD.

  公开号：EP1095996A1

  公开（公告）日：2001-05-02

  A solid has a reversibly invisible/visible thermochromic internal construction enclosed therein which is composed of a solid made of a transparent resin and a fluorescent internal construction showing the internal structure of the solid enclosed therein, wherein a reversible thermochromic layer containing a reversible thermochromic composition is formed on the surface of the solid, or the transparent resin contains a reversible thermochromic composition.

  一种固体具有可逆的不可见/可见热致变色内部结构，它由透明树脂制成的固体和显示内部结构的荧光内部结构组成，其中固体表面形成含有可逆热致变色成分的可逆热致变色层，或透明树脂含有可逆热致变色成分。
• Antioxidant activity of protocatechuates evaluated by DPPH, ORAC, and CAT methods
  作者：Claudia Grajeda-Iglesias、Erika Salas、Nathalie Barouh、Bruno Baréa、Atikorn Panya、Maria Cruz Figueroa-Espinoza

  DOI：10.1016/j.foodchem.2015.07.119

  日期：2016.3

  Hibiscus sabdariffa L. is a worldwide consumed plant, principally after infusion of its dried sepals and calyces, which are usually discarded. Nevertheless, they represent a potential source of natural bioactive compounds, e.g. polyphenols, which could add value to this under-exploited plant. Protocatechuic acid (PA) was chosen as a model of the phenolic acids that can be extracted from H. sabdariffa. In order to modify PA hydrophilic character, which limits its use in lipid-rich food products, PA was esterified to C-1-C-18 alcohols, and the impact of lipophilization on its antioxidant activity was evaluated in both, an homogeneous (DPPH and ORAC methods) and an heterogeneous (CAT method) system. Results herein obtained showed that, depending on the grafted alkyl chain length, lipophilization could positively affect the antioxidant activity of PA in heterogeneous media; therefore, support its use as an innovative way to synthesize molecules with an improved antioxidant capacity and potential to be used as multifunctional preservatives in food. (C) 2015 Elsevier Ltd. All rights reserved.
• METHOD AND MATERIAL FOR THE FORMATION OF A HEAT MODE IMAGE
  申请人：AGFA-GEVAERT N.V.

  公开号：EP0719217B1

  公开（公告）日：1998-08-12
• PROCÉDÉ DE PRÉPARATION D'UN CATALYSEUR DE REFORMAGE COMPRENANT UN SUPPORT, UN MÉTAL DU GROUPE VIIIB ET UN MÉTAL DU GROUPE VIIB
  申请人：IFP

  公开号：EP2222399A1

  公开（公告）日：2010-09-01
• PROCESS FOR PREPARING A REFORMING CATALYST COMPRISING A SUPPORT, A GROUP VIIIB METAL AND A GROUP VIIB METAL
  申请人：Oudart Yohan

  公开号：US20090143224A1

  公开（公告）日：2009-06-04

  For preparing a reforming catalyst comprising a support, a group VIIIB metal and a group VIIB metal, comprises the following steps in the order a) then b) or b) then a): a step a) impregnating the support with an aqueous solution of hydrochloric acid comprising a group VIIIB metal; a step b) impregnating the support with an aqueous solution comprising a group VIIB metal and a sulphur-containing complexing agent in a reducing environment, or a step b) impregnation with an aqueous solution comprising a group VIIB metal, then with a solution comprising a sulphur-containing complexing agent in a reducing environment. The reducing environment is any reducing atmosphere comprising more than 0.1% by weight of a reducing gas or a mixture of reducing gases; or reducing solutions comprising, with respect to the group VIIB metal, in the range 0.1 to 20 equivalents of reducing metals, reducing organic compounds or inorganic reducing compounds.