5,6-dichloro-2-(pyridin-4-yl)isoindoline-1,3-dione | 1141384-39-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 5,6-dichloro-2-(pyridin-4-yl)isoindoline-1,3-dione
• 英文别名: 5,6-Dichloro-2-pyridin-4-ylisoindole-1,3-dione
• CAS: 1141384-39-5
• 化学式: C₁₃H₆Cl₂N₂O₂
• 分子量: 293.109
• InChiKey: UOAUVXWSAGJIKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5,6-dichloro-2-(pyridin-4-yl)isoindoline-1,3-dione 、 (2,3,7,8,12,13,17,18-octaethylporphyrinato)zinc(II) 以 甲苯 为溶剂， 生成
  参考文献：
  名称：

  八乙基卟啉异构体的超分子供体-受体二元和轴向配位体的重组能：实验和计算研究

  摘要：

  内部重组能（λ V）比较了2,3,7,8,12,13,17,18-八乙基卟啉锌（II）（ZnOEP）和电子受体配体的超分子供体-受体二元组中的光诱导电子转移（ET）和结构异构体，2,3,7,8,11,12,17,18-八乙基卟啉锌（II）（ZnHPc）和2,3,6,7,12,13,16,17-八乙基卟啉锌（II）（ZnPcn）。首先，主要通过瞬态吸收光谱法研究了ZnOEP的超分子供体-受体二元组的ET过程。通过吸收光谱变化证实了超分子二元组的形成，由此估计了缔合常数。通过观察激光闪光光解过程中ZnOEP的自由基阳离子，证实了ET过程。这些二联体的ET速率为ZnOEP> ZnHPc> ZnPcn，当ET的驱动力彼此相似时。从ET率的自由能依赖性来看，λ V OEP及其异构体的值进行估计。估计λ V值在ZnOEP

  DOI：

  10.1016/j.jphotochem.2010.10.016
• 作为产物：
  描述：

  4-氨基吡啶 、 4,5-二氯邻苯二甲酸酐 在 溶剂黄146 、 碳酸氢钠 作用下， 反应 6.0h， 以75%的产率得到5,6-dichloro-2-(pyridin-4-yl)isoindoline-1,3-dione
  参考文献：
  名称：

  Synthesis and biological evaluation of some novel cyclic-imides as hypoglycaemic, anti-hyperlipidemic agents

  摘要：

  Certain new halogenated cyclic-imides related to N-substituted phthalimide moiety were synthesized. Spacers of one or two carbon atom distances were inserted to connect the N-terminus of the cyclic-imide nuclei to the used heteroaryl groups to evaluate the effect of such alteration on biological activity. The synthesized compounds were subjected to hypoglycaemic and anti-hyperlipidemic evaluation. Some of the tested compounds proved to be more potent than the reference drugs glibenclamide and clofibrate. Compound Se remarkably reduced serum glucose level by 55%; while 5c, Se, 7d and 8e reduced total serum cholesterol by 58, 56, 54 and 53%, respectively. Those new cyclic-imides could be considered as useful template for future development to obtain more potent hypoglycaemic and anti-hyperlipidemic agents. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.07.002

文献信息

• Reorganization energy of supramolecular donor–acceptor dyad of octaethylporphyrin isomers and axial-coordinated acceptor: Experimental and computational study
  作者：Mamoru Fujitsuka、Hisashi Shimakoshi、Yoshio Hisaeda、Tetsuro Majima

  DOI：10.1016/j.jphotochem.2010.10.016

  日期：2011.1

  constant was estimated. The ET process was confirmed by the observation of radical cation of ZnOEP during the laser flash photolysis. The ET rates of these dyads are in the order of ZnOEP > ZnHPc > ZnPcn, when the driving forces for ET are similar to each other. From the free energy dependence of ET rates, the λV values of OEP and its isomers were estimated. The estimated λV value was in the order of

  内部重组能（λ V）比较了2,3,7,8,12,13,17,18-八乙基卟啉锌（II）（ZnOEP）和电子受体配体的超分子供体-受体二元组中的光诱导电子转移（ET）和结构异构体，2,3,7,8,11,12,17,18-八乙基卟啉锌（II）（ZnHPc）和2,3,6,7,12,13,16,17-八乙基卟啉锌（II）（ZnPcn）。首先，主要通过瞬态吸收光谱法研究了ZnOEP的超分子供体-受体二元组的ET过程。通过吸收光谱变化证实了超分子二元组的形成，由此估计了缔合常数。通过观察激光闪光光解过程中ZnOEP的自由基阳离子，证实了ET过程。这些二联体的ET速率为ZnOEP> ZnHPc> ZnPcn，当ET的驱动力彼此相似时。从ET率的自由能依赖性来看，λ V OEP及其异构体的值进行估计。估计λ V值在ZnOEP
• Synthesis and biological evaluation of some novel cyclic-imides as hypoglycaemic, anti-hyperlipidemic agents
  作者：Alaa A.-M. Abdel-Aziz、Adel S. El-Azab、Sabry M. Attia、Abdulrahman M. Al-Obaid、Mohamed A. Al-Omar、Hussein I. El-Subbagh

  DOI：10.1016/j.ejmech.2011.07.002

  日期：2011.9

  Certain new halogenated cyclic-imides related to N-substituted phthalimide moiety were synthesized. Spacers of one or two carbon atom distances were inserted to connect the N-terminus of the cyclic-imide nuclei to the used heteroaryl groups to evaluate the effect of such alteration on biological activity. The synthesized compounds were subjected to hypoglycaemic and anti-hyperlipidemic evaluation. Some of the tested compounds proved to be more potent than the reference drugs glibenclamide and clofibrate. Compound Se remarkably reduced serum glucose level by 55%; while 5c, Se, 7d and 8e reduced total serum cholesterol by 58, 56, 54 and 53%, respectively. Those new cyclic-imides could be considered as useful template for future development to obtain more potent hypoglycaemic and anti-hyperlipidemic agents. (C) 2011 Elsevier Masson SAS. All rights reserved.