2-((4-bromophenyl)selanyl)pyridine | 1436860-96-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((4-bromophenyl)selanyl)pyridine
• 英文别名: 2-(4-Bromophenyl)selanylpyridine；2-(4-bromophenyl)selanylpyridine
• CAS: 1436860-96-6
• 化学式: C₁₁H₈BrNSe
• 分子量: 313.055
• InChiKey: XKACVHIPDCSXFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氯吡啶 、 1,2-bis(4-bromophenyl)diselenide 在 次磷酸 、 甘油 作用下， 以 水 为溶剂， 反应 2.5h， 以96%的产率得到2-((4-bromophenyl)selanyl)pyridine
  参考文献：
  名称：

  Glycerol/hypophosphorous acid: an efficient system solvent-reducing agent for the synthesis of 2-organylselanyl pyridines

  摘要：

  We describe herein an efficient and simple method to synthesize 2-organylselanyi pyridines by reactions of 2-chloropyridines with organylselenols, generated in situ by reaction of diorganyl diselenides, using glycerol as solvent and hypophosphorous acid (H3PO2) as reducing agent. Using this methodology, a range of selenium substituted pyridines was obtained in high yields. The system solvent-reducing agent glycerol/H3PO2 can be easily recovered and reused for five times without loss of efficiency. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.04.057

文献信息

• Glycerol/hypophosphorous acid: an efficient system solvent-reducing agent for the synthesis of 2-organylselanyl pyridines
  作者：Samuel Thurow、Rodrigo Webber、Gelson Perin、Eder J. Lenardão、Diego Alves

  DOI：10.1016/j.tetlet.2013.04.057

  日期：2013.6

  We describe herein an efficient and simple method to synthesize 2-organylselanyi pyridines by reactions of 2-chloropyridines with organylselenols, generated in situ by reaction of diorganyl diselenides, using glycerol as solvent and hypophosphorous acid (H3PO2) as reducing agent. Using this methodology, a range of selenium substituted pyridines was obtained in high yields. The system solvent-reducing agent glycerol/H3PO2 can be easily recovered and reused for five times without loss of efficiency. (C) 2013 Elsevier Ltd. All rights reserved.