tyrosyl-glycyl-glycine | 21778-69-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tyrosyl-glycyl-glycine
• 英文别名: tyrosylglycylglycine；2-[[2-[[2-azaniumyl-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetate
• CAS: 21778-69-8
• 化学式: C₁₃H₁₇N₃O₅
• 分子量: 295.295
• InChiKey: HIINQLBHPIQYHN-UHFFFAOYSA-N

物化性质

• 熔点：
  193-195℃
• 沸点：
  741.8±60.0 °C(Predicted)
• 密度：
  1.381

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  142
• 氢给体数：
  5
• 氢受体数：
  6

安全信息

• 海关编码：
  2924299090

文献信息

• 3-Amino-2-hydroxy-4-phenylbutanoic acid derivatives and pharmaceutical composition containing the same
  申请人：ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

  公开号：EP0077274A1

  公开（公告）日：1983-04-20

  New 3-N-acyl derivatives of 3-amino-2-hydroxy-4-phenylbutanoic acid are provided, which exhibit analgesic activity and are effective to enhance the morphine analgesia.

  本研究提供了 3-氨基-2-羟基-4-苯基丁酸的 3-N-acyl 新衍生物，它们具有镇痛活性，能有效增强吗啡镇痛效果。
• Substituted dipeptides, methods for their production, pharmaceutical compositions containing them, method for making such pharmaceutical compositions
  申请人：SCHERING CORPORATION

  公开号：EP0103077A2

  公开（公告）日：1984-03-21

  Dipeptides are disclosed having the formula in which R,, R2, R3, R4, R5 and R6 are various substituents, p is 0,1 or 2 and the asterisks indicate chiral centres. The compounds inhibit the aciton of enkephalinase in mammals. Pharmaceutical compositions containing the above compounds are described.

  已公开的二肽具有如下式子 其中 R、R2、R3、R4、R5 和 R6 为各种取代基，p 为 0、1 或 2，星号表示手性中心。 这些化合物可抑制哺乳动物体内脑啡肽酶的活性。 描述了含有上述化合物的药物组合物。
• Phosphorous containing compounds as inhibitors of enkephalinases
  申请人：SCHERING CORPORATION

  公开号：EP0117429A1

  公开（公告）日：1984-09-05

  Compounds having the general formula in which W is R' or OR', R' being hydrogen, alkyl, phenyl or benzyl Xis-(CH2)P-CHR3 or CHR3-(CH2)p- R33 is chosen from various substituents, or Z is chosen from various of organic groups, and R2 forms, with the carbonyl group to which it is attached, carboxy or various esterified carboxy groups or is the group -NR8R9. The compounds inhibit the activity of enkephalinases. Intermediates of formula are disclosed in which Wa is alkoxy, phenoxy or benzyloxy Xa is CH2CH-, and Ya is -NH2 or -NCO.

  具有通式的化合物，其中 W 是 R'或 OR'，R'是氢、烷基、苯基或苄基，Xis-(CH2)P-CHR3 或 CHR3-( )p- R33 可从各种取代基中选择，或 Z 可从各种有机基团中选择，R2 与所连接的羰基形成羧基或各种酯化羧基，或为基团 -NR8R9。 这些化合物可抑制脑啡肽酶的活性。 公开了式中的中间体，其中 Wa 是烷氧基、苯氧基或苄氧基，Xa 是 CH-，Ya 是 -NH2 或 -NCO。
• A method and means of assaying an immune system
  申请人：Imreg, Inc.

  公开号：EP0238851A2

  公开（公告）日：1987-09-30

  Methods are described for assaying human and mammalian immune system function. Methods for determining the reserve capacity of a subject's immune system to provide amplifier and suppressor responses are described, together with methods for titrating dosage amounts of agents modifying immune response. In the preferred embodiments, IL-2 or G-IFN production are used to measure positive (i.e., amplifier) immune capacity or reserve, and cell proliferation is used to measure negative (i.e., suppressor) immune capacity or reserve.

  本文介绍了测定人类和哺乳动物免疫系统功能的方法。描述了确定受试者免疫系统提供放大器和抑制器反应的储备能力的方法，以及滴定改变免疫反应的制剂剂量的方法。在优选的实施方案中，IL-2 或 G-IFN 的产生用于测量正性（即放大器）免疫能力或储备，细胞增殖用于测量负性（即抑制器）免疫能力或储备。
• Protein from lactic acid bacteria
  申请人：PROBICOM RESEARCH B.V.

  公开号：EP0522203A1

  公开（公告）日：1993-01-13

  The present invention relates to an endopeptidase of lactic acid bacteria in isolated or purified form as well as to uses thereof, e.g., in the preparation of foods such as cheese, whippable products and meat products, or for preparing antibodies against the endopeptidase. The invention also relates to recombinant genetic information coding for the endopeptidase and transformed organisms expressing the endopeptidase. The endopeptidase can be isolated from Lactococcus lactis subsp. cremoris Wg2. It has a molecular weight of 70 kD ± 5 kD; an isoelectric point of 4.1 ± 0.4; a substrate range which includes peptides having five or more amino acids, metenkaphalin, bradykinin, glucagon, oxidized insulin β-chain and neurotensin, and excludes peptides having less than 5 amino acids, and α-, β- and κ-casein; a hydrolysis activity dependent of Co²⁺; a temperature optimum at 30-38°C and a pH optimum at 6.0-6.5.

  本发明涉及一种分离或纯化形式的乳酸菌内肽酶及其用途，例如用于制备奶酪、可发产品和肉制品等食品，或制备针对内肽酶的抗体。本发明还涉及编码内肽酶的重组遗传信息和表达内肽酶的转化生物。该内肽酶可从 Lactococcus lactis subsp.它的分子量为 70 kD ± 5 kD；等电点为 4.1 ± 0.4 ；底物范围包括具有 5 个或更多氨基酸的肽、甲萘肽、缓激肽、胰高血糖素、氧化胰岛素 β 链和神经肽，不包括具有少于 5 个氨基酸的肽和α-、β- 和 κ-酪蛋白；水解活性取决于 Co²⁺；最适温度为 30-38°C，最适 pH 值为 6.0-6.5。