5-(9H-Fluoren-9-ylmethoxycarbonylamino)-isophthalic acid | 676485-93-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 5-(9H-Fluoren-9-ylmethoxycarbonylamino)-isophthalic acid
• 英文别名: 5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)benzene-1,3-dicarboxylic acid；5-(9H-fluoren-9-ylmethoxycarbonylamino)benzene-1,3-dicarboxylic acid
• CAS: 676485-93-1
• 化学式: C₂₃H₁₇NO₆
• 分子量: 403.391
• InChiKey: HOBXDIGLCVKCRY-UHFFFAOYSA-N

物化性质

• 熔点：
  313-315 °C
• 沸点：
  634.7±55.0 °C(Predicted)
• 密度：
  1.449±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-(9H-Fluoren-9-ylmethoxycarbonylamino)-isophthalic acid 、 Fmoc-O-叔丁基-L-酪氨酸 、 N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-L-赖氨酸 、 Fmoc-Lys(Dde)-OH 、 alkaline earth salt of/the/ methylsulfuric acid 生成 GU1163
  参考文献：
  名称：

  Bridged Peptide Macrocycles as Ligands for PDZ Domain Proteins

  摘要：

  Conformationally constrained side chain-bridged cyclic peptides were prepared using bis-carboxylic acid ring spacers. These macrocyles were designed to inhibit protein-protein interactions mediated by the third PDZ domain (PDZ3) of a mammalian neuronal protein, PSD-95. Isothermal titration calorimetry (ITC) experiments measured dissociation constants in the low micromolar range. For each compound, the change in entropy (TAS) of binding either is comparable in magnitude to the enthalpy change (AM or is the predominant driving force for association.

  DOI：

  10.1021/ol0475966
• 作为产物：
  描述：

  氯甲酸-9-芴基甲酯 、 5-氨基间苯二甲酸 在 sodium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以5%的产率得到5-(9H-Fluoren-9-ylmethoxycarbonylamino)-isophthalic acid
  参考文献：
  名称：

  [EN] LONG-ACTING DUAL GIP/GLP-1 PEPTIDE CONJUGATES AND METHODS OF USE
  [FR] CONJUGUÉS PEPTIDIQUES DOUBLE GIP/GLP-1 À ACTION PROLONGÉE ET PROCÉDÉS D'UTILISATION

  摘要：

  本文提供了含有双重葡萄糖依赖性胰岛素促泌肽（GIP）和GLP-1受体激动剂的肽和肽共轭物。这些肽可以用于血糖管理和治疗糖尿病、肥胖症、非酒精性脂肪肝病（NAFLD）和非酒精性脂肪性肝炎（NASH）等疾病。

  公开号：

  WO2022257979A1

文献信息

• [EN] PEPTIDE CONJUGATES AND METHODS OF USE<br/>[FR] CONJUGUÉS PEPTIDIQUES ET MÉTHODES D'UTILISATION
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2021113535A1

  公开（公告）日：2021-06-10

  Peptide conjugates comprising a peptide selected from a peptide that modulates the PYY receptor, a peptide that modulates both the GLP-1 receptor and the GCG receptor, a peptide that modulates both the GLP-1 receptor and the GIP receptor, and a peptide that modulates the GLP-1 receptor; and a staple attached to the peptide at a first amino acid and a second amino acid are disclosed herein. Also provided are peptide conjugates comprising prolactin-releasing peptide. The peptide conjugates may be used for treating conditions such as obesity. Further provided are stapled prolactin-releasing peptide.

  本文披露了包括以下内容的肽共轭物：选择自可调节PYY受体的肽、可调节GLP-1受体和GCG受体的肽、可调节GLP-1受体和GIP受体的肽、以及可调节GLP-1受体的肽；以及连接到肽的稳定剂，在第一个氨基酸和第二个氨基酸处连接。还提供了包括催乳素释放肽的肽共轭物。这些肽共轭物可用于治疗肥胖等疾病。此外，还提供了稳定的催乳素释放肽。
• [EN] LONG-ACTING DUAL GIP/GLP-1 PEPTIDE CONJUGATES AND METHODS OF USE<br/>[FR] CONJUGUÉS PEPTIDIQUES DOUBLE GIP/GLP-1 À ACTION PROLONGÉE ET PROCÉDÉS D'UTILISATION
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2022257979A1

  公开（公告）日：2022-12-15

  Provided herein are peptides and peptide conjugates comprising a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. The peptides may be used for blood glucose management and treating conditions such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), and non-alcoholic steatohepatitis (NASH).

  本文提供了含有双重葡萄糖依赖性胰岛素促泌肽（GIP）和GLP-1受体激动剂的肽和肽共轭物。这些肽可以用于血糖管理和治疗糖尿病、肥胖症、非酒精性脂肪肝病（NAFLD）和非酒精性脂肪性肝炎（NASH）等疾病。
• [EN] MYOSIN DERIVED PEPTIDES AND RELATED COMPOUNDS WITH ANTICOAGULANT ACTIVITIES<br/>[FR] PEPTIDES DÉRIVÉS DE MYOSINE ET COMPOSÉS ASSOCIÉS À ACTIVITÉS ANTICOAGULANTES
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2021021811A2

  公开（公告）日：2021-02-04
• Bridged Peptide Macrocycles as Ligands for PDZ Domain Proteins
  作者：Gomika Udugamasooriya、Dorina Saro、Mark R. Spaller

  DOI：10.1021/ol0475966

  日期：2005.3.1

  Conformationally constrained side chain-bridged cyclic peptides were prepared using bis-carboxylic acid ring spacers. These macrocyles were designed to inhibit protein-protein interactions mediated by the third PDZ domain (PDZ3) of a mammalian neuronal protein, PSD-95. Isothermal titration calorimetry (ITC) experiments measured dissociation constants in the low micromolar range. For each compound, the change in entropy (TAS) of binding either is comparable in magnitude to the enthalpy change (AM or is the predominant driving force for association.