4-(1H-indol-3-yl)phenol | 81344-97-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-(1H-indol-3-yl)phenol
• CAS: 81344-97-0
• 化学式: C₁₄H₁₁NO
• 分子量: 209.247
• InChiKey: YGTAABODIJLLHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  36
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-cinnolin-4-yl-phenol 在 乙醇 、 sodium 作用下， 生成 4-(1H-indol-3-yl)phenol
  参考文献：
  名称：

  328. Cinnolines。第十四部分。4-芳基肉桂碱的N-氧化物。4-取代的cinnolines转化为吲哚

  摘要：

  DOI：

  10.1039/jr9470001649

文献信息

• Lewis Base Catalysts and Methods Thereof
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：US20200255555A1

  公开（公告）日：2020-08-13

  The present disclosure relates to Lewis base catalysts. Catalysts, catalyst systems, and processes of the present disclosure can provide high temperature ethylene polymerization, propylene polymerization, or copolymerization as the Lewis base catalysts can be stable at high polymerization temperatures and have good activity at the high polymerization temperatures. The stable catalysts with good activity can provide formation of polymers having high melting points, high isotacticity, and controllable molecular weights, and the ability to make an increased amount of polymer in a given reactor, as compared to conventional catalysts. Hence, the present disclosure demonstrates highly active catalysts capable of operating at high reactor temperatures while producing polymers with controlled molecular weights and or robust isotacticity.

  本公开涉及路易斯碱催化剂。本公开的催化剂、催化剂体系和工艺可以提供高温乙烯聚合、丙烯聚合或共聚合，因为路易斯碱催化剂在高聚合温度下能够稳定，并且在高聚合温度下具有良好的活性。具有良好活性的稳定催化剂可以提供具有高熔点、高异构度和可控分子量的聚合物形成，并且相比传统催化剂，能够在给定反应器中生产更多量的聚合物。因此，本公开展示了能够在高反应器温度下运行的高活性催化剂，同时生产具有可控分子量和/或强偏晶性的聚合物。
• 一种4 - (1-H吲哚)苯酚衍生物的制备方法及其应用
  申请人：贵州省中国科学院天然产物化学重点实验室

  公开号：CN110054579B

  公开（公告）日：2022-07-29

  本发明公开了一种4‑(1‑H吲哚)苯酚衍生物、其制备方法和应用，其结构通式(I)如下：其中R为氢、卤原子、甲基、甲氧基、硝基、甲酯基、苄氧基等。本发明涉及的衍生物具有较好的抑制MRSA（耐甲氧西林金黄色葡萄球菌）、金黄色葡萄球菌、枯草杆菌的活性。通式(I)。
• [EN] INDOLE-CONTAINING COMPOUNDS WITH ANTI-TUBULIN AND VASCULAR TARGETING ACTIVITY<br/>[FR] COMPOSES CONTENANT DE L'INDOLE A ACTIVITE ANTI-TUBULINE ET DE CIBLAGE VASCULAIRE
  申请人：UNIV BAYLOR

  公开号：WO2004099139A1

  公开（公告）日：2004-11-18

  Trimethoxyphenyl substituted indole ligands have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin assembly. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.

  已发现了取代三甲氧基苯基吲哚配体，这些配体表现出令人印象深刻的细胞毒性，以及抑制微管组装的显著能力。这类化合物以及相关衍生物是治疗人类癌症的优秀临床候选药物。此外，这些配体中的某些作为前药，很可能被证明是肿瘤选择性血管靶向化疗药物，或具有靶向血管活性，从而选择性地预防和/或破坏非恶性增殖的血管系统。
• Friedel–Crafts Ring-Coupling Reactions Promoted by Tungsten Dearomatization Agent
  作者：Jared A. Pienkos、Victor E. Zottig、Diana A. Iovan、Mengxun Li、Daniel P. Harrison、Michal Sabat、Rebecca J. Salomon、Laura Strausberg、Victor A. Teran、William H. Myers、W. Dean Harman

  DOI：10.1021/om3012008

  日期：2013.1.28

  TpW(NO)(PMe3)(L), where L = phenol, N,N-dimethylanilinium, or naphthalene, undergo protonation followed by addition of an aromatic nucleophile. The addition of aromatic molecules occurs at the para carbon of the phenol or aniline ring or the beta carbon of the naphthalene. The addition occurs anti to the metal fragment, as determined by X-ray crystallography. In the case where L = phenol or N,N-dimethylanilinium

  配合物TpW（NO）（PMe 3）（L）（其中L =苯酚，N，N-二甲基苯铵或萘）进行质子化，然后添加芳族亲核试剂。芳族分子的添加发生在苯酚或苯胺环的对位碳或萘的β碳上。通过X射线晶体学测定，该添加抗金属碎片发生。在L ＝苯酚或N，N-二甲基苯铵的情况下，用亲电子杂原子随后用芳族亲核试剂处理键合的芳烃设置两个立构中心，两个加成均抗金属。使用硝酸铈铵通过氧化分解将所得的配体从金属中去除。
• INDOLE-BASED COMPOUNDS
  申请人：RECTICEL NV

  公开号：US20210371576A1

  公开（公告）日：2021-12-02

  The present invention relates to a compound of formula (I) or a stereoisomer, enantiomer, racemic, or tautomer thereof, formula (I) wherein r, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and L 1 have the meaning defined in the claims and the description. The present invention also relates to a process for the preparation of the compound of formula (I). The present invention also relates to a composition comprising the compound of formula (I). The present invention also relates to a polyurethane or polyurethane prepolymer obtainable by contacting at least one isocyanate with at least one compound of formula (I), or with a composition comprising a compound of formula (I). The present invention relates to the use of such polyurethane or polyurethane prepolymer, or a compound of formula (I), or a composition comprising a compound of formula (I), for the preparation of foams, adhesives, coatings, or elastomers. The present invention also relates to an article comprising a compound of formula (I), or a composition a compound of formula (I).

  本发明涉及公式（I）的化合物或其立体异构体，对映异构体，外消旋体或其互变异构体，公式（I）中r，R1，R2，R3，R4，R5，R6和L1的含义如权利要求书和说明书所定义的那样。本发明还涉及制备公式（I）化合物的方法。本发明还涉及包含公式（I）化合物的组合物。本发明还涉及通过将至少一种异氰酸酯与至少一种公式（I）化合物或包含公式（I）化合物的组合物接触而获得的聚氨酯或聚氨酯预聚体。本发明涉及使用这样的聚氨酯或聚氨酯预聚体，或公式（I）化合物，或包含公式（I）化合物的组合物，用于制备泡沫、粘合剂、涂料或弹性体。本发明还涉及包含公式（I）化合物或包含公式（I）化合物的组合物的物品。