(E)-1-(1-fluoro-2-methoxy-4-phenyl-1-(phenylsulfonyl)but-3-enylsulfonyl)benzene | 1203825-68-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1-(1-fluoro-2-methoxy-4-phenyl-1-(phenylsulfonyl)but-3-enylsulfonyl)benzene
• 英文别名: [(E)-4,4-bis(benzenesulfonyl)-4-fluoro-3-methoxybut-1-enyl]benzene
• CAS: 1203825-68-6
• 化学式: C₂₃H₂₁FO₅S₂
• 分子量: 460.547
• InChiKey: RSRPZFAOIPJBTC-ISLYRVAYSA-N

物化性质

• 熔点：
  151-153 °C
• 沸点：
  702.4±60.0 °C(Predicted)
• 密度：
  1.323±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  94.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  氟双(苯基磺酰基)甲烷 、 (3-methoxyprop-1-yn-1-yl)benzene 在 四(三苯基膦)钯 、 溶剂黄146 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 以91%的产率得到(E)-1-(1-fluoro-2-methoxy-4-phenyl-1-(phenylsulfonyl)but-3-enylsulfonyl)benzene
  参考文献：
  名称：

  Palladium/acetic acid-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones as pronucleophiles

  摘要：

  A facile palladium-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones in the presence of acetic acid has been achieved. By using different alpha-substituted fluoro(phenyisulfonyl)methane derivatives, a variety of allylated monofluoromethyl compounds were obtained with high regio- and stereoselectivity. Substrate scope and limitation were also examined, and it was found that the reaction was amenable to both 1-aryl-substituted propynes and 3-aryl-substituted propynyl ethers. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.09.126

文献信息

• Palladium/acetic acid-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones as pronucleophiles
  作者：Chuanfa Ni、Jinbo Hu

  DOI：10.1016/j.tetlet.2009.09.126

  日期：2009.12

  A facile palladium-catalyzed fluoroalkylation of alkynes with monofluorinated sulfones in the presence of acetic acid has been achieved. By using different alpha-substituted fluoro(phenyisulfonyl)methane derivatives, a variety of allylated monofluoromethyl compounds were obtained with high regio- and stereoselectivity. Substrate scope and limitation were also examined, and it was found that the reaction was amenable to both 1-aryl-substituted propynes and 3-aryl-substituted propynyl ethers. (C) 2009 Elsevier Ltd. All rights reserved.