N-allyl-4-(4-methoxyphenyl)thiazol-2-amine | 21344-97-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-allyl-4-(4-methoxyphenyl)thiazol-2-amine
• 英文别名: 4-(4-methoxyphenyl)-N-(prop-2-en-1-yl)-1,3-thiazol-2-amine；4-(4-methoxyphenyl)-N-prop-2-enyl-1,3-thiazol-2-amine
• CAS: 21344-97-8
• 化学式: C₁₃H₁₄N₂OS
• mdl: MFCD02735504
• 分子量: 246.333
• InChiKey: AQVPCHXIIGFLID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.153
• 拓扑面积：
  62.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对甲氧基苯乙酮 在 potassium carbonate 、 copper(I) bromide 作用下， 以 乙酸乙酯 为溶剂， 反应 5.0h， 生成 N-allyl-4-(4-methoxyphenyl)thiazol-2-amine
  参考文献：
  名称：

  Facile One-Pot Procedure for the Synthesis of 2-Aminothiazole Derivatives

  摘要：

  A facile, efficient synthesis of 2-aminothiazole derivatives by the reaction of easily available aromatic methyl ketones with thiourea/N-substituted thioureas in the presence of copper(II) bromide was developed. The reaction underwent a one-pot alpha-bromination/cyclization process.

  DOI：

  10.3987/com-12-12510

文献信息

• Parallel Solution-Phase Synthesis of a 2-Aminothiazole Library Including Fully Automated Work-Up
  作者：Hans-Peter Buchstaller、Uwe Anlauf

  DOI：10.2174/138620711794474024

  日期：2011.2.1

  and effective procedure for the solution phase preparation of a 2-aminothiazole combinatorial library is described. Reaction, work-up and isolation of the title compounds as free bases was accomplished in a fully automated fashion using the Chemspeed ASW 2000 automated synthesizer. The compounds were obtained in good yields and excellent purities without any further purification procedure.

  描述了2-氨基噻唑组合文库溶液相制备的直接有效方法。使用Chemspeed ASW 2000自动合成仪以全自动方式完成标题化合物作为游离碱的反应，后处理和分离。无需任何进一步纯化步骤即可以良好的产率和优异的纯度获得化合物。
• Facile One-Pot Procedure for the Synthesis of 2-Aminothiazole Derivatives
  作者：Guodong Yin、Junrui Ma、Houqiang Shi、Qing Tao

  DOI：10.3987/com-12-12510

  日期：——

  A facile, efficient synthesis of 2-aminothiazole derivatives by the reaction of easily available aromatic methyl ketones with thiourea/N-substituted thioureas in the presence of copper(II) bromide was developed. The reaction underwent a one-pot alpha-bromination/cyclization process.