cis-(N(1)-(2'-tetrahydrofuranyl)-5-fluorouracilato)chlorodiammineplatinum(II) | 172649-96-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: cis-(N(1)-(2'-tetrahydrofuranyl)-5-fluorouracilato)chlorodiammineplatinum(II)
• 英文别名: azane;chloroplatinum(1+);5-fluoro-1-(oxolan-2-yl)pyrimidin-3-ide-2,4-dione
• CAS: 172649-96-6
• 化学式: C₈H₁₄ClFN₄O₃Pt
• 分子量: 463.756
• InChiKey: XLNFJJIMUQEOAB-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -2.91
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  67
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  替加氟 、 cisplatin 在 Ag₂O 作用下， 以 水 为溶剂， 以77.3%的产率得到cis-(N(1)-(2'-tetrahydrofuranyl)-5-fluorouracilato)chlorodiammineplatinum(II)
  参考文献：
  名称：

  摘要：

  The reaction between cis-[Pt(NH3)(2)Cl-2], N'-(2'-tetrahydrofuranyl)-5-fluorouracil (HL), and NaOH (taken in a molar ratio of 1 : 1 : 1) or between cis-[Pt(NH3)(2)Cl-2], HL, and Ag2O (taken in the molar ratio of 1 : 1 : 0.5) was used to synthesize complexes Ia (in the case of NaOH) or Ib (in the case of Ag2O) with composition Pt(NH3)(2)LCl. The model complex [Pt(NH3)(3)L]NO3 (II) was synthesized by the reaction between [Pt(NH3)(3)Cl]Cl, HL, AgNO3, and Ag2O (1 : 1 : 1 : 0.5). The obtained compounds were characterized by chemical analysis, chromatography, thermogravimetry, conductometry, potentiometry, IR, electronic, and NMR spectroscopies. Complexes Ia and Ib were found to have both similar and different properties. The structures of the compounds and the type of L- coordination to platinum(II) were suggested. Cytotoxic properties of la and Ib were studied.

  DOI：

  10.1023/a:1016080811978

文献信息

• ——
  作者：M. F. Mogilevkina、V. A. Shipachev、S. V. Tkachev、G. P. Troshkova、L. D. Martynets

  DOI：10.1023/a:1016080811978

  日期：——

  The reaction between cis-[Pt(NH3)(2)Cl-2], N'-(2'-tetrahydrofuranyl)-5-fluorouracil (HL), and NaOH (taken in a molar ratio of 1 : 1 : 1) or between cis-[Pt(NH3)(2)Cl-2], HL, and Ag2O (taken in the molar ratio of 1 : 1 : 0.5) was used to synthesize complexes Ia (in the case of NaOH) or Ib (in the case of Ag2O) with composition Pt(NH3)(2)LCl. The model complex [Pt(NH3)(3)L]NO3 (II) was synthesized by the reaction between [Pt(NH3)(3)Cl]Cl, HL, AgNO3, and Ag2O (1 : 1 : 1 : 0.5). The obtained compounds were characterized by chemical analysis, chromatography, thermogravimetry, conductometry, potentiometry, IR, electronic, and NMR spectroscopies. Complexes Ia and Ib were found to have both similar and different properties. The structures of the compounds and the type of L- coordination to platinum(II) were suggested. Cytotoxic properties of la and Ib were studied.