N-(1-phenylethyl)acetanilide | 116420-00-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1-phenylethyl)acetanilide
• 英文别名: N-phenyl-N-(1-phenylethyl)acetamide
• CAS: 116420-00-9
• 化学式: C₁₆H₁₇NO
• 分子量: 239.317
• InChiKey: PTJGOQGKUUNSFZ-UHFFFAOYSA-N

物化性质

• 沸点：
  363.4±21.0 °C(Predicted)
• 密度：
  1.092±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  苯乙酮 在 copper(l) iodide 、 四丁基碘化铵 、 对甲苯磺酸 、 lithium tert-butoxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 11.0h， 生成 N-(1-phenylethyl)acetanilide
  参考文献：
  名称：

  铜催化的酰胺与衍生自酮的N-甲苯磺酰hydr的还原N-烷基化反应

  摘要：

  本文介绍了CuI催化的酮基N-甲苯磺酰with与酰胺的还原偶联。在最佳条件下，衍生自芳基烷基和二芳基酮的一系列N-甲苯磺酰could可以与多种（杂）芳基以及脂肪族酰胺有效偶联，从而以高收率获得N-烷基化酰胺。该方法代表了通过还原性N烷基化方案可靠地获得仲和叔酰胺的例子。

  DOI：

  10.1002/asia.201600733

文献信息

• One-Step Hydroamidation of a Schiff Base with Trichlorosilane
  作者：Hidenori Okamoto、Shozo Kato

  DOI：10.1246/bcsj.64.2128

  日期：1991.7

  We have found that the treatment of a Schiff base (2) with trichlorosilane and chloroacetyl chloride results in a highly active chloroacetamide herbicide (1) in an excellent yield. This one-step hydroamidation reaction of a Schiff base is a useful synthetic method.

  我们已经发现，将席夫碱（2）与三氯硅烷和氯乙酰氯进行处理，可以高产率地得到一种活性极高的氯乙酰胺类除草剂（1）。这种席夫碱的一步水合酰胺化反应是一种有用的合成方法。
• Application of the Intermolecular α-Amido-alkylation Reaction for the Synthesis of Tertiary Amides and 1-Substituted 2-Acyltetrahydroiso-Quinolines. Synthesis of (±)-Carnegine
  作者：Atanas P. Venkov、Stela M. Statkova-Abeghe

  DOI：10.1080/00397919508015425

  日期：1995.6

  Abstract Adducts 4 of Schiff bases and 3,4-dihydroisoquinolines with acyl chlorides react with Grignard reagents 5 in an intermolecular α-amidoalkylation reaction to the corresponding tertiary amides or 1-substituted 2-acyltetrahydroisoquinolines.

  摘要 Schiff 碱和 3,4-二氢异喹啉与酰氯的加合物 4 与格氏试剂 5 在分子间 α-酰胺烷基化反应中反应生成相应的叔酰胺或 1-取代的 2-酰基四氢异喹啉。
• FLUORINATION METHOD
  申请人：Oxford University Innovation Limited

  公开号：US20170137341A1

  公开（公告）日：2017-05-18

  The present invention relates to a process for producing an organic compound comprising an 18 F atom. The compounds comprising an 18 F can be useful as PET ligands for use in diagnostics and/or scanning. The process of the invention comprises treating an organoboron compound, which organoboron compound comprises a boron atom bonded to an sp 2 hybridised carbon atom, with (i) 18 F— and (ii) a copper compound. The invention also provides the use of an organoboron compound, which organoboron compound comprises a boron atom bonded to an sp 2 hybridised carbon atom, in a process for producing an organic compound comprising an 18 F atom, which process comprises treating the organoboron compound with (i) 18 F— and (ii) a copper compound. The invention also provides a compound of formula (XXXVII): wherein: each PG A is independently H or an alcohol protecting group; PG B is H or a carboxylic acid protecting group; each PG C is independently an amine protecting group; Z is a group selected from a boronic ester group, a boronic acid group, a borate group, and a trifluoroborate group; and a is an integer from 0 to 4.
• Copper-Catalyzed Reductive<i>N</i>-Alkylation of Amides with<i>N</i>-Tosylhydrazones Derived from Ketones
  作者：Peng Xu、Fu-Ling Qi、Fu-She Han、Yan-Hua Wang

  DOI：10.1002/asia.201600733

  日期：2016.7.20

  A CuI‐catalyzed reductive coupling of ketone‐derived N‐tosylhydrazones with amides is presented. Under the optimized conditions, an array of N‐tosylhydrazones derived from aryl–alkyl and diaryl ketones could couple effectively with a wide variety of (hetero)aryl as well as aliphatic amides to afford the N‐alkylated amides in high yields. The method represents the very few examples for reliably accessing

  本文介绍了CuI催化的酮基N-甲苯磺酰with与酰胺的还原偶联。在最佳条件下，衍生自芳基烷基和二芳基酮的一系列N-甲苯磺酰could可以与多种（杂）芳基以及脂肪族酰胺有效偶联，从而以高收率获得N-烷基化酰胺。该方法代表了通过还原性N烷基化方案可靠地获得仲和叔酰胺的例子。