2-Biphenyl-4-yl-1-(4-pyrrolidin-1-ylpiperidin-1-yl)ethanone hydrochloride | 512193-09-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Biphenyl-4-yl-1-(4-pyrrolidin-1-ylpiperidin-1-yl)ethanone hydrochloride
• 英文别名: 2-(4-phenylphenyl)-1-(4-pyrrolidin-1-ylpiperidin-1-yl)ethanone;hydrochloride
• CAS: 512193-09-8
• 化学式: C₂₃H₂₈N₂O*ClH
• 分子量: 384.949
• InChiKey: QICLOCHFLCLLBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  23.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-联苯乙酸 、 4-吡咯烷-1-基哌啶 、 硝苯酚 以 乙醇 、 1,2-二氯丙烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-Biphenyl-4-yl-1-(4-pyrrolidin-1-ylpiperidin-1-yl)ethanone hydrochloride
  参考文献：
  名称：

  Novel substituted piperidines

  摘要：

  一种新型的取代哌啶类化合物，包括它们的药物组成和用于治疗与组胺H3受体相关的疾病和疾病障碍的用途。更具体地说，这些化合物可用于治疗与组胺H3受体相互作用有益的疾病和疾病障碍。

  公开号：

  US20030191112A1

文献信息

• Substituted piperidines
  申请人：Novo Nordisk Inc.

  公开号：US07064135B2

  公开（公告）日：2006-06-20

  A novel class of substituted piperidines, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.

  一种新的取代哌啶类化合物、包含它们的药物组合物以及它们在治疗与组胺H3受体相关的疾病和障碍方面的应用。更具体地说，这些化合物可用于治疗与组胺H3受体相互作用有益的疾病和障碍。
• Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor
  申请人：High Point Pharmaceuticals, LLC

  公开号：EP2243776A1

  公开（公告）日：2010-10-27

  A novel class of substituted piperidines, pharmaceutical compositions comprising them and use thereof in the treatment of disease and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and dis-orders in which an interaction with the histamine H3 receptor is beneficial.

  一类新型取代的哌啶类化合物、包含它们的药物组合物及其在治疗与组胺 H3 受体有关的疾病和紊乱中的用途。更具体地说，这些化合物可用于治疗与组胺 H3 受体相互作用有益的疾病和紊乱。
• SUBSTITUTED PIPERIDINES AND THEIR USE FOR THE TREATMENT OF DISEASES RELATED TO THE HISTAMINE H3 RECEPTOR
  申请人：NOVO NORDISK A/S

  公开号：EP1444219A1

  公开（公告）日：2004-08-11
• US7064135B2
  申请人：——

  公开号：US7064135B2

  公开（公告）日：2006-06-20
• [EN] SUBSTITUTED PIPERIDINES AND THEIR USE FOR THE TREATMENT OF DISEASES RELATED TO THE HISTAMINE H3 RECEPTOR<br/>[FR] NOUVELLES PIPERIDINES SUBSTITUEES
  申请人：NOVO NORDISK AS

  公开号：WO2003031432A1

  公开（公告）日：2003-04-17

  A novel class of substituted piperidines, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and dis-orders in which an interaction with the histamine H3 receptor is beneficial.