2-(Furan-2-yl)nonan-2-ol | 475086-00-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-(Furan-2-yl)nonan-2-ol
• 英文别名: 2-(furan-2-yl)nonan-2-ol
• CAS: 475086-00-1
• 化学式: C₁₃H₂₂O₂
• 分子量: 210.316
• InChiKey: SDXWXFKPLKSZKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  33.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(Furan-2-yl)nonan-2-ol 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Novel bicyclic oxazolone derivatives as anti-Angiogenic agents

  摘要：

  Novel bicyclic tetrahydropyrano[3,2-4]oxazolones derivatives, analogues of Fumagillin, were synthesised via a stereo-controlled oxidative-rearrangement of furylcarbinols and subsequent treatment with the appropriate isocyanate. These compounds demonstrated potent antiangiogenic activity. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00197-x
• 作为产物：
  描述：

  2-乙酰基呋喃 、 n-heptyllithium 以 四氢呋喃 为溶剂， 以94%的产率得到2-(Furan-2-yl)nonan-2-ol
  参考文献：
  名称：

  Novel bicyclic oxazolone derivatives as anti-Angiogenic agents

  摘要：

  Novel bicyclic tetrahydropyrano[3,2-4]oxazolones derivatives, analogues of Fumagillin, were synthesised via a stereo-controlled oxidative-rearrangement of furylcarbinols and subsequent treatment with the appropriate isocyanate. These compounds demonstrated potent antiangiogenic activity. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00197-x

文献信息

• Novel bicyclic oxazolone derivatives as anti-Angiogenic agents
  作者：Françoise M Perron-Sierra、Alain Pierré、Mike Burbridge、Nicolas Guilbaud

  DOI：10.1016/s0960-894x(02)00197-x

  日期：2002.6

  Novel bicyclic tetrahydropyrano[3,2-4]oxazolones derivatives, analogues of Fumagillin, were synthesised via a stereo-controlled oxidative-rearrangement of furylcarbinols and subsequent treatment with the appropriate isocyanate. These compounds demonstrated potent antiangiogenic activity. (C) 2002 Elsevier Science Ltd. All rights reserved.