8-oxo-7-phenylacetylamino-3-(2,3,3,3-tetrachloro-propionyloxymethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester | 142478-57-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 8-oxo-7-phenylacetylamino-3-(2,3,3,3-tetrachloro-propionyloxymethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
• 英文别名: benzhydryl (6R,7R)-8-oxo-7-[(2-phenylacetyl)amino]-3-(1,2,2,2-tetrachloroethoxycarbonyloxymethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• CAS: 142478-57-7
• 化学式: C₃₂H₂₆Cl₄N₂O₇S
• 分子量: 724.446
• InChiKey: YSAPWDKJNGSQIH-FFBJGFBZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  46
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  137
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  8-oxo-7-phenylacetylamino-3-(2,3,3,3-tetrachloro-propionyloxymethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 在 碳酸氢钠 、 苯甲醚 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.58h， 生成 (6R,7R)-3-[[4-(3-carboxy-1-cyclopropyl-6-fluoro-4-oxo-7-quinolyl)piperazine-1-carbonyl]oxymethyl]-8-oxo-7-[(2-phenylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  参考文献：
  名称：

  Syntheses and studies of quinolone-cephalosporins as potential anti-tuberculosis agents

  摘要：

  The syntheses and anti-tuberculosis activity of quinolone-cephalosporin conjugates (1 and 2) are described. Both showed broad-spectrum antibacterial activity and significant anti-TB activity. The carbamate-linked quinolone-cephem 2 showed better antimycobacterial activity, including anti-TB activity, than the direct amine-linked quinolone-cephem 1, while quinolone-cephem 1 was slightly more effective against some Gram-negative bacterial strains. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.045
• 作为产物：
  描述：

  羟甲基-7-氨基头孢烷酸 在 吡啶 、 苯磺酰胺 作用下， 以 二氯甲烷 、 N,N-二甲基乙酰胺 、 乙酸乙酯 为溶剂， 反应 3.58h， 生成 8-oxo-7-phenylacetylamino-3-(2,3,3,3-tetrachloro-propionyloxymethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
  参考文献：
  名称：

  Syntheses and studies of quinolone-cephalosporins as potential anti-tuberculosis agents

  摘要：

  The syntheses and anti-tuberculosis activity of quinolone-cephalosporin conjugates (1 and 2) are described. Both showed broad-spectrum antibacterial activity and significant anti-TB activity. The carbamate-linked quinolone-cephem 2 showed better antimycobacterial activity, including anti-TB activity, than the direct amine-linked quinolone-cephem 1, while quinolone-cephem 1 was slightly more effective against some Gram-negative bacterial strains. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.08.045

文献信息

• Syntheses and studies of quinolone-cephalosporins as potential anti-tuberculosis agents
  作者：Gaiying Zhao、Marvin J. Miller、Scott Franzblau、Baojie Wan、Ute Möllmann

  DOI：10.1016/j.bmcl.2006.08.045

  日期：2006.11

  The syntheses and anti-tuberculosis activity of quinolone-cephalosporin conjugates (1 and 2) are described. Both showed broad-spectrum antibacterial activity and significant anti-TB activity. The carbamate-linked quinolone-cephem 2 showed better antimycobacterial activity, including anti-TB activity, than the direct amine-linked quinolone-cephem 1, while quinolone-cephem 1 was slightly more effective against some Gram-negative bacterial strains. (c) 2006 Elsevier Ltd. All rights reserved.