(2-phenylpyrimidin-5-yl)(piperazin-1-yl)methanone | 1196065-74-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (2-phenylpyrimidin-5-yl)(piperazin-1-yl)methanone
• 英文别名: (2-phenylpyrimidin-5-yl)-piperazin-1-ylmethanone
• CAS: 1196065-74-3
• 化学式: C₁₅H₁₆N₄O
• 分子量: 268.318
• InChiKey: NPOSPXCDSNTPGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  58.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ammonium hydroxide 、 tert-butyl 4-(2-phenylpyrimidine-5-carbonyl)piperazine-1-carboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以94%的产率得到(2-phenylpyrimidin-5-yl)(piperazin-1-yl)methanone
  参考文献：
  名称：

  METHOD FOR ASSAYING COMPOUNDS OR AGENTS FOR ABILITY TO DISPLACE POTENT LIGANDS OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE

  摘要：

  一个示范性实施例可能涉及一种荧光极化测定法，该方法通过检测化合物或试剂对血液造血素D合成酶（H-PGDS）的亲和力来筛选，其基于它们能够将结合到具有H-PGDS主要氨基酸序列的酶上的含荧光团的检测分析物位移开。另一个示范性实施例利用具有麦芽糖结合蛋白氨基酸序列的酶，与酶的N-末端融合。

  公开号：

  US20090286261A1

文献信息

• Method for assaying compounds or agents for ability to displace potent ligands of hematopoietic prostaglandin D synthase
  申请人：Palackal Nisha

  公开号：US08440417B2

  公开（公告）日：2013-05-14

  An exemplary embodiment may be directed to a fluorescence polarization assay that screens compounds or agents for their affinity to hematopoietic prostaglandin D synthase (H-PGDS) based on their ability to displace a fluorophore-containing detection analyte bound to an enzyme comprising the primary amino acid sequence of H-PGDS. Another exemplary embodiment utilizes an enzyme having a maltose binding protein amino-acid sequence fused with an N-terminus of the enzyme.

  一个典型的实施例可能是针对荧光偏振测定法，该测定法基于化合物或试剂对血液生成素D合酶（H-PGDS）亲和力的筛选，其基于其能力来置换与H-PGDS主要氨基酸序列组成的酶结合的含荧光物质的检测分析物。另一个典型实施例利用了一种酶，该酶具有与麦芽糖结合蛋白氨基酸序列融合的N-末端。
• METHODS FOR ASSAYING COMPOUNDS OR AGENTS FOR ABILITY TO DISPLACE POTENT LIGANDS OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE
  申请人：Cayman Chemical Company

  公开号：EP2286221A2

  公开（公告）日：2011-02-23
• US8440417B2
  申请人：——

  公开号：US8440417B2

  公开（公告）日：2013-05-14
• [EN] METHODS FOR ASSAYING COMPOUNDS OR AGENTS FOR ABILITY TO DISPLACE POTENT LIGANDS OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE<br/>[FR] PROCÉDÉS D'ÉVALUATION DE LA CAPACITÉ DE COMPOSÉS OU D'AGENTS À DÉPLACER DE PUISSANTS LIGANDS DE LA PROSTAGLANDINE D SYNTHASE HÉMATOPOÏÉTIQUE
  申请人：CAYMAN CHEM CO

  公开号：WO2009140364A2

  公开（公告）日：2009-11-19

  An exemplary embodiment may be directed to a fluorescence polarization assay that screens compounds or agents for their affinity to hematopoietic prostaglandin D synthase (H-PGDS) based on their ability to displace a fluorophore-containing detection analyte bound to an enzyme comprising the primary amino acid sequence of H-PGDS. Another exemplary embodiment utilizes an enzyme having a maltose binding protein amino-acid sequence fused with an N- terminus of the enzyme.
• METHOD FOR ASSAYING COMPOUNDS OR AGENTS FOR ABILITY TO DISPLACE POTENT LIGANDS OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE
  申请人：Maxey Kirk W.

  公开号：US20090286261A1

  公开（公告）日：2009-11-19

  An exemplary embodiment may be directed to a fluorescence polarization assay that screens compounds or agents for their affinity to hematopoietic prostaglandin D synthase (H-PGDS) based on their ability to displace a fluorophore-containing detection analyte bound to an enzyme comprising the primary amino acid sequence of H-PGDS. Another exemplary embodiment utilizes an enzyme having a maltose binding protein amino-acid sequence fused with an N-terminus of the enzyme.

  一个示范性实施例可能涉及一种荧光极化测定法，该方法通过检测化合物或试剂对血液造血素D合成酶（H-PGDS）的亲和力来筛选，其基于它们能够将结合到具有H-PGDS主要氨基酸序列的酶上的含荧光团的检测分析物位移开。另一个示范性实施例利用具有麦芽糖结合蛋白氨基酸序列的酶，与酶的N-末端融合。