2-Hydroxypropane-1,2,3-tricarboxylic acid;octadecanoic acid;propane-1,2,3-triol | 100359-41-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Hydroxypropane-1,2,3-tricarboxylic acid;octadecanoic acid;propane-1,2,3-triol
• 英文别名: 2-hydroxypropane-1,2,3-tricarboxylic acid;octadecanoic acid;propane-1,2,3-triol
• CAS: 100359-41-9
• 化学式: C27H52O12
• 分子量: 568.7
• InChiKey: LRPFVGWWAKSVOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.42
• 重原子数：
  39
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  230
• 氢给体数：
  8
• 氢受体数：
  12

文献信息

• Vehicle systems for use in cosmetic compositions
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0412710A2

  公开（公告）日：1991-02-13

  Disclosed is a unique vehicle system which provides a desirable rheology to products formulated therewith, enhanced dispersion of actives therein, and improved deposition of actives therefrom. This vehicle system comprises a primary thickening agent which is a nonionic long-chain alkylated water-soluble polymer, and a secondary thickening agent which is a water-insoluble surfactant dispersed in a compatible solvent. Optionally, a rheological aid, which is a chelating agent may be included in the vehicle system. Also, optionally, a distributing aid, which is a water-soluble polymer of either high molecular weight or strong ionic character may be included in the vehicle system. These vehicle systems are useful in cosmetic compositions which are used to deliver an active component to the hair or skin. The vehicle systems are particularly useful in hair care compositions, especially rinse-off hair conditioning compositions, because they effectively deliver the hair conditioning component to the hair without depositing a substantial amount of the vehicle material onto the hair.

  本发明公开了一种独特的载体系统，它能为用其配制的产品提供理想的流变性，增强活性物质在其中的分散，并改善活性物质在其中的沉积。这种载体系统包括一种主增稠剂（非离子型长链烷基化水溶性聚合物）和一种辅助增稠剂（分散在兼容溶剂中的水不溶性表面活性剂）。可选择在载体系统中加入流变助剂，即螯合剂。此外，载体体系中还可以加入一种分配辅助剂，即一种高分子量或强离子性的水溶性聚合物。这些载体系统适用于将活性成分输送到头发或皮肤的化妆品组合物。这些载体系统尤其适用于护发组合物，特别是冲洗型护发组合物，因为它们能有效地将护发成分输送到头发上，而不会在头发上沉积大量的载体材料。
• METHOD OF PRODUCING DRUG-CONTAINING WAX MATRIX PARTICLES, EXTRUDER TO BE USED IN THE METHOD AND SUSTAINED-RELEASE PREPARATION CONTAINING CILOSTAZOL
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP1970040A1

  公开（公告）日：2008-09-17

  The present invention aims to provide a method for producing, by a simple method, drug-containing wax matrix granules, particularly drug-containing wax matrix granules having an average particle diameter of 1 mm or lower, while avoiding liquid blockage due to the recrystallization of a molten drug during the period from a melting step to a spray step. Drug-containing wax matrix granules having at least one wax and at least one drug are produced by the following steps (i) and (ii): (i) supplying the at least one drug and the at least one wax to an extruder in which the temperature of a barrel and the temperature of a die are adjusted to be higher than the melting point of the at least one wax; and (ii) while melting and kneading the at least one drug and the at least one wax in the extruder to give a molten kneaded drug and wax, spraying the molten kneaded drug and wax into an atmosphere having a temperature lower than the melting point of the wax from a spray nozzle directly mounted onto a die provided at a top end of the barrel of the extruder, thereby forming the mixture into granules.

  本发明旨在提供一种用简单方法生产含药蜡基质颗粒的方法，特别是平均颗粒直径为1毫米或更小的含药蜡基质颗粒，同时避免在从熔化步骤到喷雾步骤期间由于熔融药物的再结晶而造成的液体堵塞。 通过以下步骤(i)和(ii)生产具有至少一种蜡和至少一种药物的含药蜡基质颗粒：(i) 将至少一种药物和至少一种蜡提供给挤压机，在挤压机中，机筒的温度和模具的温度被调节到高于至少一种蜡的熔点；(ii) 在挤压机中熔化和揉捏至少一种药物和至少一种蜡以得到熔融的揉捏药物和蜡时，从直接安装在挤压机机筒上端模头的喷嘴向温度低于蜡熔点的大气中喷射熔融的揉捏药物和蜡，从而将混合物制成颗粒。
• METHOD FOR PRODUCTION OF CAPSINOID-CONTAINING BEVERAGE/FOOD
  申请人：Ajinomoto Co., Inc.

  公开号：EP2008532A1

  公开（公告）日：2008-12-31

  Provided is a method for producing a capsinoid-containing food/drink article with a superior stability of the capsinoid compound, and an emulsion composition comprising a capsinoid compound with an improved dilution stability thereof. The method comprises the steps of blending an oil phase containing a capsinoid compound with an aqueous phase and an emulsifier to prepare an emulsion composition, and mixing the emulsion composition with an aqueous diluent component, wherein an additional emulsifier and/or a high-molecular component is added to the emulsion composition, the aqueous diluent component or a mixture thereof.

  本发明提供了一种生产含胶囊基化合物的食品/饮料产品的方法，其胶囊基化合物具有优异的稳定性，还提供了一种含胶囊基化合物的乳液组合物，其稀释稳定性得到改善。该方法包括以下步骤：将含有辣椒素化合物的油相与水相和乳化剂混合，制备乳液组合物；将乳液组合物与水性稀释剂成分混合，其中在乳液组合物、水性稀释剂成分或其混合物中添加额外的乳化剂和/或高分子成分。
• PANAXADIOL-CONTAINING COMPOSITION
  申请人：Lion Corporation

  公开号：EP2711011A1

  公开（公告）日：2014-03-26

  A panaxadiol-containing composition, containing: panaxadiol; and at least one of sucrose fatty acid ester and lecithin.

  一种含板蓝根二醇的组合物，包含：板蓝根二醇；以及蔗糖脂肪酸酯和卵磷脂中的至少一种。
• Method of producing drug-containing wax matrix particles, extruder to be used in the method and sustained-release preparation containing cilostazol
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP2724704A1

  公开（公告）日：2014-04-30

  A sustained-release preparation is provided which contains granules comprising (A) cilostazol crystals; and (B) glycerol fatty acid ester and/or polyglycerol fatty acid ester. The average particle diameter of the granules ranges from 40 to 200 µm.

  本发明提供了一种缓释制剂，其中包含由以下成分组成的颗粒：(A) 西洛他唑晶体；(B) 甘油脂肪酸酯和/或聚甘油脂肪酸酯。颗粒的平均粒径为 40 至 200 微米。