bis-[2-(4-nitro-benzoylamino)-phenyl]-disulfide | 21164-16-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis-[2-(4-nitro-benzoylamino)-phenyl]-disulfide
• 英文别名: Bis-[2-(4-nitro-benzoylamino)-phenyl]-disulfid；2.2'-Bis-(4-nitro-benzamino)-diphenyldisulfid；4-nitro-N-[2-[[2-[(4-nitrobenzoyl)amino]phenyl]disulfanyl]phenyl]benzamide
• CAS: 21164-16-9
• 化学式: C₂₆H₁₈N₄O₆S₂
• 分子量: 546.584
• InChiKey: ZXRVHDCFSMYTKG-UHFFFAOYSA-N

物化性质

• 沸点：
  614.5±55.0 °C(Predicted)
• 密度：
  1.52±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  200
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  bis-[2-(4-nitro-benzoylamino)-phenyl]-disulfide 在 盐酸 、 tin 作用下， 生成 4-(2-苯并噻唑基)苯胺
  参考文献：
  名称：

  Bogert; Snell, Journal of the American Chemical Society, 1924, vol. 46, p. 1310

  摘要：

  DOI：
• 作为产物：
  描述：

  zinc 2-aminobenzenethiolate 在 ammonium hydroxide 、 air 、 乙醚 作用下， 生成 bis-[2-(4-nitro-benzoylamino)-phenyl]-disulfide
  参考文献：
  名称：

  Bogert; Snell, Journal of the American Chemical Society, 1924, vol. 46, p. 1310

  摘要：

  DOI：

文献信息

• CETP ACTIVITY INHIBITORS
  申请人：Shinkai Hisashi

  公开号：US20130053417A1

  公开（公告）日：2013-02-28

  The invention provides a compound that is a CETP activity inhibitor. The compound can increase HDL and at the same time decrease LDL through selective inhibition of CETP activity, the invention also provides for the use of the compound to prevent or treat atherosclerosis or hyperlipidemia.

  本发明提供了一种CETP活性抑制剂的化合物。该化合物可以通过选择性抑制CETP活性来增加HDL并同时降低LDL，本发明还提供了使用该化合物预防或治疗动脉粥样硬化或高脂血症的方法。
• CETP Activity Inhibitors
  申请人：Shinkai Hisashi

  公开号：US20080027109A1

  公开（公告）日：2008-01-31

  The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): wherein R represents a straight chain or branched alkyl group; a straight chain or branched alkenyl group; a lower haloalkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted cycloalkenyl group; a substituted or unsubstituted cycloalkylalkyl group; a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group, X 1 , X 2 , X 3 , and X 4 may be the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower haloalkyl group; a lower alkoxy group; a cyano group; a nitro group; an acyl group; or an aryl group, Y represents —CO— or —SO 2 —, and Z represents a hydrogen atom or a mercapto-protecting group, or a prodrug compound, a pharmaceutically acceptable salt, or hydrate or solvate thereof. The compounds represented by the formula (I) can increase HDL and at the same time decrease LDL through selective inhibition of CETP activity and, therefore, is expected to be useful as a new type of a preventive or therapeutic agent for atherosclerosis or hyperlipidemia.

  本发明提供了一种CETP活性抑制剂，其包含以下式子（I）表示的化合物作为活性成分：其中R表示直链或支链烷基；直链或支链烯基；低卤代烷基；取代或未取代环烷基；取代或未取代环烯基；取代或未取代环烷基烷基；取代或未取代芳基；或取代或未取代杂环基，X1、X2、X3和X4可以相同或不同，每个表示氢原子、卤素原子、低烷基、低卤代烷基；低烷氧基；氰基；硝基；酰基；或芳基，Y表示—CO—或—SO2—，Z表示氢原子或巯基保护基，或其前药化合物，药学上可接受的盐或其水合物或溶剂化物。式（I）所表示的化合物可以通过选择性抑制CETP活性增加HDL并同时降低LDL，因此预计可作为一种新型的预防或治疗动脉粥样硬化或高脂血症的药物。
• Solid phase synthesis of benzothiazolyl compounds
  作者：Spyros Mourtas、Dimitrios Gatos、Kleomenis Barlos

  DOI：10.1016/s0040-4039(01)00109-5

  日期：2001.3

  2-Aminobenzenethiol, bound through its thiol function to the 2-chlorotrityl (Clt)-, trityl (Trt)-, 4-methyltrityl (Mtt)- and 4-methoxytrityl (Mmt)-resins, was acylated at the amino-function by aliphatic and aromatic acids. The obtained 2-N-acylaminobenzenethiols were cleaved from the resin by treatment with trifluoroacetic acid solutions in dichloromethane. The 2-N-acyl-aminobenzenethiols released from the resin were cyclised to the corresponding 2-substituted benzothiazoles, by standing in a solution of dithiothreitol in DMF or methanol for 1-3 h at room temperature. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Imoto; Kiriyama, Kogyo Kagaku zasshi / Journal of the Society of Chemical Industry, 1952, vol. 55, p. 95,96
  作者：Imoto、Kiriyama

  DOI：——

  日期：——
• US7271196B2
  申请人：——

  公开号：US7271196B2

  公开（公告）日：2007-09-18