decyl-pyridine-2-yl-amine | 101259-87-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: decyl-pyridine-2-yl-amine
• 英文别名: N-decylpyridin-2-amine；2-(decylamino)pyridine；decyl-[2]pyridyl-amine；Decyl-pyridin-2-yl-amine
• CAS: 101259-87-4
• 化学式: C₁₅H₂₆N₂
• mdl: MFCD06637442
• 分子量: 234.385
• InChiKey: SVNPVKIONFWLJU-UHFFFAOYSA-N

物化性质

• 熔点：
  51-52 °C
• 沸点：
  351.6±15.0 °C(Predicted)
• 密度：
  0.934±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  17
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  decyl-pyridine-2-yl-amine 在 sodium hydroxide 、 三乙胺 、 potassium iodide 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Identification of novel PPARα ligands by the structural modification of a PPARγ ligand

  摘要：

  To develop novel PPAR alpha ligands, we designed and synthesized several 3-{3-[2-(nonylpyridin-2-ylamino)ethoxy]phenyl}-propanoic acid derivatives. Compound 10, the meta isomer of a PPAR gamma agonist 1, has been identified as a PPAR alpha ligand. The introduction of methyl and ethyl groups at the C-2 position of the propanoic acid of 10 further improved the PPAR alpha-binding potency. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.03.031
• 作为产物：
  描述：

  2-氨基吡啶 、 癸醇 在 三(2-呋喃基)膦 、 palladacycle 、 lithium hydroxide 作用下， 以 neat (no solvent) 为溶剂， 反应 24.0h， 以92%的产率得到decyl-pyridine-2-yl-amine
  参考文献：
  名称：

  使用醇的胺N-烷基化的环金属化钯前催化剂和使用芳基醇的磺胺的区域选择性烷基化

  摘要：

  已经开发出具有高周转率的简单的吡唑基四氢环磷酰胺，并将其用于通过醇借用策略以醇为底物的胺和磺胺的N-烷基化。在无溶剂条件下，伯胺和仲胺的N-烷基化可在100-130°C的条件下实现高分离产率。在相似的反应条件下，更具挑战性的仲脂族和芳族醇也成功地用作烷基化剂。使用苯甲醇对苯胺进行N-苄基化反应的周转数达到43000。值得注意的是，使用醇作为烷基化剂，已经实现了2-氨基苯并噻唑和4-氨基苯磺酰胺的区域选择性N-烷基化为相应的2-N-（烷基氨基）唑和4-氨基-（N-烷基）苯磺酰胺的区域选择性。 -膦系统。

  DOI：

  10.1016/j.tet.2017.03.001

文献信息

• Development of new DMAP-related organocatalysts for use in the Michael addition reaction of β-ketoesters in water
  作者：Kyungmin Ko、Keiji Nakano、Shigeru Watanabe、Yoshiyasu Ichikawa、Hiyoshizo Kotsuki

  DOI：10.1016/j.tetlet.2009.04.025

  日期：2009.7

  A general and efficient protocol for the Michael addition reactions of β-ketoesters in pure water has been developed. The reactions are successfully catalyzed by newly designed DMAP-related organocatalysts such as 4-(didecylamino)pyridine, and the desired Michael adducts are obtained in good to high yields

  已经开发出一种在纯水中进行β-酮酸酯的迈克尔加成反应的通用有效方案。通过新设计的DMAP相关有机催化剂（例如4-（十二烷基氨基）吡啶）成功催化了反应，并以高收率或高收率获得了所需的迈克尔加合物
• Efficient reduction of azides with samarium diiodide
  作者：Catherine Goulaouic-Dubois、Manfred Hesse

  DOI：10.1016/0040-4039(95)80003-4

  日期：1995.10

  Reduction of alkyl, aryl and aroyl azides to the parent primary amines or amides, respectively, occurs in good yield upon treatment with an excess of SmI2 in THF at room temperature. A radical mechanism is proposed.

  在室温下用过量的SmI 2在THF中处理后，烷基，芳基和芳基叠氮化物分别还原成母体伯胺或酰胺，收率良好。提出了一种激进的机制。
• Design, synthesis, and biological activity of novel PPARγ ligands based on rosiglitazone and 15d-PGJ2
  作者：Shinya Usui、Takayoshi Suzuki、Yoshifumi Hattori、Kazuma Etoh、Hiroki Fujieda、Makoto Nishizuka、Masayoshi Imagawa、Hidehiko Nakagawa、Kohfuku Kohda、Naoki Miyata

  DOI：10.1016/j.bmcl.2005.01.074

  日期：2005.3

  To develop novel PPAR gamma ligands, we synthesized thirteen 3-4-(2-aminoethoxy)phenyl}propanoic acid derivatives, which are designed based on the structures of rosiglitazone and 15d-PGJ(2). Among these compounds, compound 9 was found to be as potent as rosiglitazone in a binding assay and a preadipocyte differentiation test. Molecular modeling suggested that the nonyl group of 9 interacted with hydrophobic amino acid residues constructing the hydrophobic region of PPAR gamma protein where the alkyl chain of 15d-PGJ(2) is expected to be located. (c) 2005 Elsevier Ltd. All rights reserved.
• 382. Long-chain alkyl derivatives of 2-aminopyridine
  作者：Thomas M. Sharp

  DOI：10.1039/jr9390001855

  日期：——
• Identification of novel PPARα ligands by the structural modification of a PPARγ ligand
  作者：Shinya Usui、Hiroki Fujieda、Takayoshi Suzuki、Naoaki Yoshida、Hidehiko Nakagawa、Naoki Miyata

  DOI：10.1016/j.bmcl.2006.03.031

  日期：2006.6

  To develop novel PPAR alpha ligands, we designed and synthesized several 3-3-[2-(nonylpyridin-2-ylamino)ethoxy]phenyl}-propanoic acid derivatives. Compound 10, the meta isomer of a PPAR gamma agonist 1, has been identified as a PPAR alpha ligand. The introduction of methyl and ethyl groups at the C-2 position of the propanoic acid of 10 further improved the PPAR alpha-binding potency. (c) 2006 Elsevier Ltd. All rights reserved.