6-(oxiran-2-yl)hexan-1-ol | 107536-58-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-(oxiran-2-yl)hexan-1-ol
• 英文别名: 6-(oxiran-2-yl)hexanol
• CAS: 107536-58-3
• 化学式: C₈H₁₆O₂
• 分子量: 144.214
• InChiKey: KMHQJKFCDQXYLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-癸烷磺酰氯 、 6-(oxiran-2-yl)hexan-1-ol 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 6-(oxiran-2-yl)hexyl decane-1-sulfonate
  参考文献：
  名称：

  [EN] AMINOLIPIDOIDS AND USES THEREOF
  [FR] AMINOLIPIDOÏDES ET UTILISATIONS DE CEUX-CI

  摘要：

  本公开涉及新型氨基脂质类化合物，包括至少一种活性剂的配方，以及将至少一种活性剂传递给目标生物体的方法。

  公开号：

  WO2017100744A1
• 作为产物：
  描述：

  7-辛烯-1-醇 在 吡唑 、 双氧水 、 甲基三氧化铼(VII) 作用下， 以 二氯甲烷 、 水 为溶剂， 生成 6-(oxiran-2-yl)hexan-1-ol
  参考文献：
  名称：

  [EN] OXAZOLOBENZIMIDAZOLE DERIVATIVES
  [FR] DÉRIVÉS D'OXAZOLOBENZIMIDAZOLE

  摘要：

  本发明涉及噁唑苯并咪唑衍生物，它们是代谢型谷氨酸受体增强剂，特别是mGluR2受体，对于与谷氨酸功能障碍相关的神经和精神障碍以及代谢型谷氨酸受体参与的疾病的治疗或预防有用。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗代谢型谷氨酸受体参与的这些疾病中使用这些化合物和组合物的用途。

  公开号：

  WO2010036544A1

文献信息

• Macrocyclization by Nickel-Catalyzed, Ester-Promoted, Epoxide-Alkyne Reductive Coupling: Total Synthesis of (−)-Gloeosporone
  作者：James D. Trenkle、Timothy F. Jamison

  DOI：10.1002/anie.200902079

  日期：——

  Ringing the changes: The total synthesis of the title compound centers around a novel strategy that employs a nickel(0)–phosphine complex and triethyl borane in an efficient closure of a 14‐membered ring through CC bond formation (see scheme; cod=cyclooctadiene). The synthesis was accomplished in 10 steps and in approximately 9 % overall yield.

  改变变化：标题化合物的全合成围绕一种新策略，该策略采用镍 (0)-膦配合物和三乙基硼烷通过 C  C 键形成有效闭合 14 元环（参见方案；cod = 环辛二烯）。合成分 10 步完成，总产率约为 9%。
• Modified ethylene-vinyl alcohol copolymer and method for the production thereof
  申请人：——

  公开号：US20040096683A1

  公开（公告）日：2004-05-20

  Provided is a modified ethylene-vinyl alcohol copolymer (C) having an ethylen content of 5 to 55 mol %, which contains a specific structural unit (I) in an amount of 0.3 to 40 mol % and may be obtained by reacting an ethylene-vinyl alcohol copolymer (A) with a monofunctional epoxy compound (B) having a molecular weight of not more than 500. This can be produced by a method for producing the modified ethylene-vinyl alcohol copolymer (C) which comprises melting and kneading an ethylene-vinyl alcohol copolymer (A) with a monofunctional epoxy compound (B) in an extruder. The modified ethylene-vinyl alcohol copolymer (C) is superior to a unmodified ethylene-vinyl alcohol copolymer (A) in transparency, stretchability, flexibility and flexing resistance due to the specific structural unit (I) incorporated therein, and thus, can be used as a barrier material in various applications requiring the above performance capabilities.

  提供的是一种改性乙烯-醋酸乙烯共聚物(C)，其乙烯含量为5至55摩尔％，其中含有一种特定的结构单元(I)，其含量为0.3至40摩尔％，可通过将乙烯-醋酸乙烯共聚物(A)与分子量不超过500的单官能环氧化合物(B)反应而获得。该改性乙烯-醋酸乙烯共聚物(C)的制备方法包括在挤出机中熔融和揉捏乙烯-醋酸乙烯共聚物(A)与单官能环氧化合物(B)。由于其中包含了特定的结构单元(I)，改性乙烯-醋酸乙烯共聚物(C)在透明度、可伸展性、柔韧性和耐弯曲性方面优于未改性的乙烯-醋酸乙烯共聚物(A)，因此可以用作在需要上述性能能力的各种应用中的障壁材料。
• Monomeric diols, phosphate linked oligomers formed therefrom and processes for preparing
  申请人：——

  公开号：US20030065146A1

  公开（公告）日：2003-04-03

  Novel ethylene glycol compounds bearing various functional groups are used to prepare oligomeric structures. The ethylene glycol monomers can be joined via standard phosphate linkages including phosphodiester and phosphorothioate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding.

  新型乙二醇化合物带有各种功能基团，用于制备寡聚体结构。乙二醇单体可以通过标准的磷酸酯和磷酸硫酯键连接。有用的功能基团包括核苷碱以及极性基团，疏水基团，离子基团，芳香基团和/或参与氢键的基团。
• Resin composition and multi-layer structures
  申请人：Tai Shinji

  公开号：US20050147778A1

  公开（公告）日：2005-07-07

  Provided is a resin composition comprising 1-99% by weight of a modified ethylene-vinyl alcohol copolymer (C) having an ethylene content of 5-55 mol %, which contains a specific structural unit (I) in an amount of 0.3-40 mol % and can be obtained by reacting an ethylene-vinyl alcohol copolymer (A) with a monofunctional epoxy compound (B) having a molecular weight of not more than 500, and 1-99% by weight of a thermoplastic resin (T 1 ) other than (C). Moreover, a multilayer structure in which the resin composition and a thermoplastic resin (T 2 ) are laminated is also provided. Thus, a resin composition superior in barrier properties, transparency, stretchability, flexibility, flexing resistance and interlayer adhesiveness and various kinds of molded articles made thereof are provided.

  本发明提供了一种树脂组合物，包括重量百分比为1-99%的改性乙烯-醇酸共聚物(C)，该共聚物的乙烯含量为5-55摩尔％，其中含有特定的结构单元(I)，其含量为0.3-40摩尔％，可以通过将乙烯-醇酸共聚物(A)与分子量不超过500的单官能环氧化合物(B)反应而获得，以及重量百分比为1-99%的热塑性树脂(T1)，该树脂组合物和热塑性树脂(T2)层压形成多层结构。因此，提供了一种优异的阻隔性、透明性、可拉伸性、柔韧性、耐弯曲性和层间粘附性的树脂组合物及其各种成型制品。
• OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION
  申请人：Okada Minoru

  公开号：US20090221586A1

  公开（公告）日：2009-09-03

  The present invention provides a oxazole compound represented by Formula (1), or a salt thereof: wherein R 1 is an aryl group which may have one or more substituents; R 2 is an aryl group or a nitrogen atom-containing heterocyclic group each of which may have one or more substituents; and W is a divalent group represented by —Y 1 -A 1 - or —Y 2 —C(═O)— wherein Y 1 is a group such as —C(═O)—, A 1 is a group such as a lower alkylene group, and Y 2 is a group such as a piperazinediyl group. The oxazole compound has a specific inhibitory action against phosphodiesterase 4.

  本发明提供了一种由公式（1）表示的噁唑化合物或其盐：其中，R1是一个芳基基团，可以具有一个或多个取代基；R2是一个芳基基团或含有氮原子的杂环基团，每个基团都可以具有一个或多个取代基；W是一个由—Y1-A1-或—Y2—C（═O）—表示的二价基团，其中Y1是例如—C（═O）—的基团，A1是例如低碳链基团的基团，而Y2是例如哌嗪二基基团的基团。该噁唑化合物具有特定的磷酸二酯酶4的抑制作用。