5-benzoyl-8-hydroxy quinoline | 1028-71-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-benzoyl-8-hydroxy quinoline
• 英文别名: 5-Benzoyl-8-chinolinol；5-Benzoyl-8-hydroxy-chinolin；5-benzoyl-8-quinolinol；(8-hydroxy-[5]quinolyl)-phenyl ketone；(8-Hydroxy-[5]chinolyl)-phenyl-keton；8-Hydroxy-5-quinolyl phenyl ketone；(8-hydroxyquinolin-5-yl)-phenylmethanone
• CAS: 1028-71-3
• 化学式: C₁₆H₁₁NO₂
• mdl: MFCD23542927
• 分子量: 249.269
• InChiKey: JVHWRVMKLLDQHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-benzoyl-8-hydroxy quinoline 在 盐酸 、 一水合肼 作用下， 以 水 、 乙二醇 为溶剂， 生成 5-(苯基甲基)喹啉-8-醇
  参考文献：
  名称：

  1,2,3,4-tetrahydro-8-quinolinol derivatives and anti-allergic use thereof

  摘要：

  巨噬细胞中的白三烯生物合成受到具有以下结构的化合物及其药用盐的抑制，其中R.sub.1和R.sub.2均为氢，R.sub.3为烷基或芳基烷基；R.sub.1和R.sub.3均为氢，R.sub.2为芳基甲基或芳基羰基；R.sub.1为甲基，R.sub.2为芳基甲基，R.sub.3为氢；或者R.sub.1为七个或更多碳的烷基或芳基烷基，R.sub.2和R.sub.3均为氢。

  公开号：

  US04843082A1
• 作为产物：
  描述：

  苯喹酯 在 三氯化铝 、 硝基苯 作用下， 生成 5-benzoyl-8-hydroxy quinoline
  参考文献：
  名称：

  Thakor; Shah, Journal of the Indian Chemical Society, 1954, vol. 31, p. 597

  摘要：

  DOI：

文献信息

• 119Sn Mössbauer spectral studies in Sn(IV) and organotin(IV) substituted oxinates
  作者：K.D. Ghuge、P. Umapathy、M.P. Gupta、D.N. Sen

  DOI：10.1016/0022-1902(81)80197-2

  日期：1981.1

  Sn(IV) and organotin(IV) compounds of the type SnL2X2(X = Cl and HL = 5-acetyl-, benzol-, or phenylazo-, 8-quinolinol), SnX4 · 2HL′(X = Cl or Br and HL′=8-quinolinol-N-Oxide), R2SnL2(R = CH3, C2H5, C4H9, C8H17 or C6H5) and R3SnL(R = C6H5) have been synthesized and characterized. The 119mSn Mössbauer spectra of these compounds have been recorded at 77°K and probable structures from the Mössbauer parameters

  SnL 2 X 2类型的几种Sn（IV）和有机锡（IV）化合物（X = Cl，HL = 5-乙酰基，苯甲酰基或苯偶氮基，8-喹啉醇），SnX 4 ·2HL'（X = Cl或Br且HL'= 8-喹啉醇-N-氧化物），R 2 SnL 2（R = CH 3，C 2 H 5，C 4 H 9，C 8 H 17或C 6 H 5）和R 3 SnL （R ＝ C 6 H 5）已经合成并表征。在119米这些化合物的SnMössbauer光谱已在77°K记录下来，并根据Mössbauer参数推断出可能的结构。R 2 SnL 2螯合物（QS =约2.0 mm / sec。）被认为具有两个R-基团在八面体结构中占据顺式位置。化合物SnX 4 ·2HL'的Mössbauer光谱已通过图形解析，四极分裂值（约0.75 mm / sec。）强烈暗示了Sn（IV）四卤化物加合物的反式构型。
• Synthesis of Red-Shifted 8-Hydroxyquinoline Derivatives Using Click Chemistry and Their Incorporation into Phosphorylation Chemosensors
  作者：Juan A. González-Vera、Elvedin Luković、Barbara Imperiali

  DOI：10.1021/jo901369k

  日期：2009.10.2

  Protein phosphorylation is a ubiquitous post-translational modification, and protein kinases, the enzymes that catalyze the phosphoryl transfer, are involved in nearly every aspect of normal, as well as aberrant, cell function. Here we describe the synthesis of novel. red-shifted 8-hydroxyquinoline-based fluorophores and their incorporation into peptidyl kinase activity reporters. Replacement of the sulfonamide group of the sulfonamido-oxine (1, Sox) chromophore, which has been previously used In kinase sensing, by a 1,4-substituted triazole moiety prepared via click chemistry resulted in a significant bathochromic shift in the fluorescence excitation (15 nm) and emission (40 rim) maxima for the Mg2+ chelate. Furthermore, when a click derivative was incorporated into a chemosensor for MK2, the kinase accepted the new substrate as efficiently as the previously reported Sox-based sensor. Taken together, these results extend the utility range of kinase sensors that are based on chelation-enhanced fluorescence (CHEF).
• Ketone und Alkylderivate des 8-Oxychinolins.
  作者：Karl-wilhelm Rosenmund、Gertrud Karst

  DOI：10.1002/ardp.19412790503

  日期：——
• Substituted 8-quinolinols
  申请人：SCHENLEY IND INC

  公开号：US02770619A1

  公开（公告）日：1956-11-13
• Photo-Fries rearrangement: Rearrangement of benzoyloxy compounds
  作者：Pavan K. Sharma、Rajinder N. Khanna

  DOI：10.1007/bf00799968

  日期：1985.3