(R)-(+)-5-ethyl-5-methyl-1,3-dioxolane-2,4-dione | 149312-28-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧戊环
• 英文名称: (R)-(+)-5-ethyl-5-methyl-1,3-dioxolane-2,4-dione
• 英文别名: (5R)-5-ethyl-5-methyl-1,3-dioxolane-2,4-dione
• CAS: 149312-28-7
• 化学式: C₆H₈O₄
• 分子量: 144.127
• InChiKey: YPLHDYIZKJCGNE-ZCFIWIBFSA-N

物化性质

• 沸点：
  146.7±23.0 °C(Predicted)
• 密度：
  1.203±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (R)-(+)-5-ethyl-5-methyl-1,3-dioxolane-2,4-dione 在 4-二甲氨基吡啶 、 三氯化铝 、 三溴化硼 、 三乙胺 、 sodium iodide 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 47.67h， 生成 quassimarin
  参考文献：
  名称：

  (R)-(+)- and (S)-(-)-5-Ethyl-5-methyl-1,3-dioxolane-2,4-dione reagents for the direct preparation of .alpha.-hydroxy-.alpha.-methylbutyrate esters: assignment of the absolute configuration of the .alpha.-acetoxy-.alpha.-methylbutyrate ester side chain of quassimarin via total synthesis

  摘要：

  The preparation and use of (R)-(+)- and (S)-(-)-5-ethyl-5-methyl-1,3-dioxolane-2,4-diones for the direct preparation of chiral alpha-hydroxy-alpha-methylbutyrate esters are described.

  DOI：

  10.1021/jo00067a004
• 作为产物：
  描述：

  (R)-2-羟基-2-甲基丁酸 、 alkaline earth salt of/the/ methylsulfuric acid 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以64%的产率得到(R)-(+)-5-ethyl-5-methyl-1,3-dioxolane-2,4-dione
  参考文献：
  名称：

  (R)-(+)- and (S)-(-)-5-Ethyl-5-methyl-1,3-dioxolane-2,4-dione reagents for the direct preparation of .alpha.-hydroxy-.alpha.-methylbutyrate esters: assignment of the absolute configuration of the .alpha.-acetoxy-.alpha.-methylbutyrate ester side chain of quassimarin via total synthesis

  摘要：

  The preparation and use of (R)-(+)- and (S)-(-)-5-ethyl-5-methyl-1,3-dioxolane-2,4-diones for the direct preparation of chiral alpha-hydroxy-alpha-methylbutyrate esters are described.

  DOI：

  10.1021/jo00067a004

文献信息

• (R)-(+)- and (S)-(-)-5-Ethyl-5-methyl-1,3-dioxolane-2,4-dione reagents for the direct preparation of .alpha.-hydroxy-.alpha.-methylbutyrate esters: assignment of the absolute configuration of the .alpha.-acetoxy-.alpha.-methylbutyrate ester side chain of quassimarin via total synthesis
  作者：Eric D. Moher、Paul A. Grieco、Jon L. Collins

  DOI：10.1021/jo00067a004

  日期：1993.7

  The preparation and use of (R)-(+)- and (S)-(-)-5-ethyl-5-methyl-1,3-dioxolane-2,4-diones for the direct preparation of chiral alpha-hydroxy-alpha-methylbutyrate esters are described.